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Atopic Dermatitis Exacerbated by Inhalant Allergens

Atopic Dermatitis Exacerbated by Inhalant Allergens Abstract To the Editor.— Although the very definition of atopic dermatitis (AD) associates it with a personal or family history of allergic disease, an immunologic mechanism for the disease remains poorly defined. Patients with AD may have elevated serum IgE levels and positive immediate skin test reactions to numerous environmental allergens,1 thus suggesting that reaginic antibodies might play a role in the pathogenesis of this disease. Reports of specific allergens causing a flare of the disease were common in the past, but are rare in the recent literature. We describe a patient with AD whose disease appeared to be greatly aggravated by inhalant allergens. Report of a Case.— A 17-year-old girl with a family history of allergic disease and a personal history of severe contact allergy to poison ivy experienced an urticarial eruption on exposure to the fumes of a commercial cleanser. Reexposure in an enclosed area resulted in acute References 1. Cheng DS, Hanifin JM: Atopic dermatitis , in Thiers BH, Dobson RL (eds): Pathogenesis of Skin Disease . New York, Churchill Livingstone Inc, 1986, pp 13-23. 2. Dahl MV, Lobitz WC Jr, Dobson RL: Atopic dermatitis , in Demis DJ, Thiers BH, Smith EB (eds): Clinical Dermatology . New York, Harper & Row Publishers Inc, 1986, vol 3, pp 1-35. 3. Tuft L: Importance of inhalant allergens in atopic dermatitis . J Invest Dermatol 1949;12:211-219. 4. Marcucci F, Sensi LG, Bizarri G: Specific IgE to food and inhalant allergens in intestinal washings of children affected by atopic eczema . Clin Allergy 1985;15:345-354.Crossref 5. Hoffman DR, Yamamoto FY, Geller B, et al: Specific IgE antibodies in atopic eczema . J Allergy Clin Immunol 1975;55:256-267.Crossref 6. Sampson HA: Role of immediate food hypersensitivity in the pathogenesis of atopic dermatitis . J Allergy Clin Immunol 1983; 71:473-480.Crossref 7. Reitamo S, Visa K, Kahonen K, et al: Eczematous reactions in atopic patients caused by epicutaneous testing with inhalant allergens . Br J Dermatol 1986;114:303-309.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Atopic Dermatitis Exacerbated by Inhalant Allergens

Archives of Dermatology , Volume 123 (11) – Nov 1, 1987

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Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1987.01660350031010
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Although the very definition of atopic dermatitis (AD) associates it with a personal or family history of allergic disease, an immunologic mechanism for the disease remains poorly defined. Patients with AD may have elevated serum IgE levels and positive immediate skin test reactions to numerous environmental allergens,1 thus suggesting that reaginic antibodies might play a role in the pathogenesis of this disease. Reports of specific allergens causing a flare of the disease were common in the past, but are rare in the recent literature. We describe a patient with AD whose disease appeared to be greatly aggravated by inhalant allergens. Report of a Case.— A 17-year-old girl with a family history of allergic disease and a personal history of severe contact allergy to poison ivy experienced an urticarial eruption on exposure to the fumes of a commercial cleanser. Reexposure in an enclosed area resulted in acute References 1. Cheng DS, Hanifin JM: Atopic dermatitis , in Thiers BH, Dobson RL (eds): Pathogenesis of Skin Disease . New York, Churchill Livingstone Inc, 1986, pp 13-23. 2. Dahl MV, Lobitz WC Jr, Dobson RL: Atopic dermatitis , in Demis DJ, Thiers BH, Smith EB (eds): Clinical Dermatology . New York, Harper & Row Publishers Inc, 1986, vol 3, pp 1-35. 3. Tuft L: Importance of inhalant allergens in atopic dermatitis . J Invest Dermatol 1949;12:211-219. 4. Marcucci F, Sensi LG, Bizarri G: Specific IgE to food and inhalant allergens in intestinal washings of children affected by atopic eczema . Clin Allergy 1985;15:345-354.Crossref 5. Hoffman DR, Yamamoto FY, Geller B, et al: Specific IgE antibodies in atopic eczema . J Allergy Clin Immunol 1975;55:256-267.Crossref 6. Sampson HA: Role of immediate food hypersensitivity in the pathogenesis of atopic dermatitis . J Allergy Clin Immunol 1983; 71:473-480.Crossref 7. Reitamo S, Visa K, Kahonen K, et al: Eczematous reactions in atopic patients caused by epicutaneous testing with inhalant allergens . Br J Dermatol 1986;114:303-309.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1987

References