Abstract It is now well known that invasion of the central nervous system takes place early in the course of a syphilitic infection.1 In fact, it is the concensus of opinion that the fate of the nervous system in relation to this infection is usually determined during the first period of generalization of the disease.2 It has been asserted authoritatively that if the spinal fluid is negative at the time of the first examination, the test need not be repeated during the course of active treatment unless a lapse in treatment occurs.3 Such statements are qualified by the strict employment of modern principles of treatment in relation to the management of early syphilis. Rest intervals between courses of arsphenamin must be short, since the substitution of treatment at this early stage prevents the development of an immunity mechanism which would tend to hold the infection in check.4 References 1. Wile, U. J., and Hasley, C. K.: Involvement of the Nervous System During the Primary Stage of Syphilis, Continued Study , J. A. M. A. 76:8-9 ( (Jan. 1) ) 1921.Crossref 2. Wile, U. J., and Stokes, J. H.: Involvement of the Nervous System During the Primary Stage of Syphilis , J. A. M. A. 64:979-982 ( (March 20) ) 1915.Crossref 3. Wile, U. J., and Marshall, C. H.: A Study of the Spinal Fluid in One Thousand Eight Hundred and Sixty-Nine Cases of Syphilis in all Stages , Arch. Dermat. & Syph. 3:272-278 ( (March) ) 1921. 4. Fordyce, J. A.: The Importance of Recognizing and Treating Neurosyphilis in the Early Period of the Infection , Am. J. Med. Sc. 161:313-327, 1921. 5. Moore, J. E.: The Genesis of Neurosyphilis , Arch. Dermat. & Syph. 4:55-61 ( (July) ) 1921. 6. Brown, W. H., and Pearce, Louise: The Resistance (or Immunity) Developed by the Reaction to Syphilitic Infection and Some of the Effects of the Supression of This Reaction , Arch. Dermat. & Syph. 2:675-678 ( (Dec.) ) 1920. 7. Akatsu, S., and Noguchi, H.: The Drug-Fastness of Spirochetes to Arsenic Mercurial and Iodide Compounds in Vitro , J. Exper. Med. 25:349-362, 1917. 8. Solomon, H. C., and Klauder, J. V.: Provocative Reactions in the cerebrospinal Fluid in Neurosyphilis , Arch. Dermat. & Syph. 2:679-691 ( (Dec.) ) 1920.
Archives of Dermatology and Syphilology – American Medical Association
Published: Aug 1, 1924