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Asterol: Further Search for Neurological Disturbances

Asterol: Further Search for Neurological Disturbances Abstract In a preliminary report1 we described our findings in 39 children who had received topical applications of Asterol (2-dimethylamino-6 [β-diethylaminoethoxy] -benzothiazole) dihydrochloride for the treatment of tinea capitis. Pertinent to this subject was the high incidence (38%) of abnormalities in the pretreatment EEG's of these patients. Two children developed hallucinations during therapy, and three others showed electroencephalographic changes only. Reapplication of Asterol in polyethylene glycol (Carbowax) to four of these patients for prolonged periods of time failed to reproduce these findings. We have extended our search for neurologic disturbances, and it is the purpose of the present communication to describe and review our experience with a total of 151 children, who were observed for signs of neurotoxicity associated with the administration of Asterol. All of the patients in this study were obtained from the tinea-capitis clinic at this hospital. The patients were divided into two groups as follows: The References 1. Holowach, J.; O'Leary, J. L., and Thurston, D. L.: A. M. A. Am. J. Dis. Child. 87:261-272 ( (March) ) 1954. 2. Wilson, J. W.; Levitt, H.; Harris, T. L., and Heiligman, E. M.: J. A. M. A. 150:1002-1004 ( (Nov. 8) ) 1952.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Asterol: Further Search for Neurological Disturbances

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Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1956.02060020583010
Publisher site
See Article on Publisher Site

Abstract

Abstract In a preliminary report1 we described our findings in 39 children who had received topical applications of Asterol (2-dimethylamino-6 [β-diethylaminoethoxy] -benzothiazole) dihydrochloride for the treatment of tinea capitis. Pertinent to this subject was the high incidence (38%) of abnormalities in the pretreatment EEG's of these patients. Two children developed hallucinations during therapy, and three others showed electroencephalographic changes only. Reapplication of Asterol in polyethylene glycol (Carbowax) to four of these patients for prolonged periods of time failed to reproduce these findings. We have extended our search for neurologic disturbances, and it is the purpose of the present communication to describe and review our experience with a total of 151 children, who were observed for signs of neurotoxicity associated with the administration of Asterol. All of the patients in this study were obtained from the tinea-capitis clinic at this hospital. The patients were divided into two groups as follows: The References 1. Holowach, J.; O'Leary, J. L., and Thurston, D. L.: A. M. A. Am. J. Dis. Child. 87:261-272 ( (March) ) 1954. 2. Wilson, J. W.; Levitt, H.; Harris, T. L., and Heiligman, E. M.: J. A. M. A. 150:1002-1004 ( (Nov. 8) ) 1952.Crossref

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: Jun 1, 1956

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