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Abstract In a preliminary report1 we described our findings in 39 children who had received topical applications of Asterol (2-dimethylamino-6 [β-diethylaminoethoxy] -benzothiazole) dihydrochloride for the treatment of tinea capitis. Pertinent to this subject was the high incidence (38%) of abnormalities in the pretreatment EEG's of these patients. Two children developed hallucinations during therapy, and three others showed electroencephalographic changes only. Reapplication of Asterol in polyethylene glycol (Carbowax) to four of these patients for prolonged periods of time failed to reproduce these findings. We have extended our search for neurologic disturbances, and it is the purpose of the present communication to describe and review our experience with a total of 151 children, who were observed for signs of neurotoxicity associated with the administration of Asterol. All of the patients in this study were obtained from the tinea-capitis clinic at this hospital. The patients were divided into two groups as follows: The References 1. Holowach, J.; O'Leary, J. L., and Thurston, D. L.: A. M. A. Am. J. Dis. Child. 87:261-272 ( (March) ) 1954. 2. Wilson, J. W.; Levitt, H.; Harris, T. L., and Heiligman, E. M.: J. A. M. A. 150:1002-1004 ( (Nov. 8) ) 1952.Crossref
A.M.A. Journal of Diseases of Children – American Medical Association
Published: Jun 1, 1956
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