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Asteroid Bodies in Necrobiosis Lipoidica

Asteroid Bodies in Necrobiosis Lipoidica Abstract Introduction Asteroid bodies are seen not infrequently in dermatopathologic material. These bodies, which have also been called spiculated bodies, radial inclusions, and stellate inclusions in giant cells, have been reported in a variety of pathologic states, including leprosy,1 cryptococcosis,2 a probable case of Weber-Christian disease,3 dermoids, sebaceous cysts, paraffinomas, scars, tuberculosis,4 sarcoid,5 foreign-body granulomas, blastomycosis, various malignancies,6 granulomatosis disciformis chronica et progressiva,7 multiple myeloma,8 cavernous hemangioma, erythema induratum, lipoid pneumonia, diabetes mellitus, and pernicious anemia.9 A review of the literature does not reveal a case of necrobiosis lipoidica associated with asteroid bodies. They have been described in the lung, lymph nodes, liver, spleen, breast, uterus, ovaries, epididymis, and thyroid, as well as in the skin and subcutaneous tissue.9 Obviously, asteroid bodies are not characteristic of any disease. The pathologic alterations in which they are found References 1. References 6 and 9. 2. References 4, 6, and 9. 3. References 4 and 6. 4. Lever, W. F., in discussion on Helman.10 brand, Montgomery, and Rynearson,11 5. References 5 and 13. 6. Mallory, F. B.: The Principles of Pathologic Histology , Philadelphia, W. B. Saunders Company, 1914, pp. 207 and 613. 7. Stoddard, J. L., and Cutler, E. C.: Torula Infection in Man , Monograph 16, Rockefeller Institute for Medical Research, Baltimore, Waverly Press, 1916, p. 55. 8. Görl, P.: Ein Beitrag zur Kasuistik des subcutanen Sarkoids Darier-Roussy , Arch. Dermat. u. Syph. 148:130, 1924.Crossref 9. Hirsch, E. F.: Radial Inclusions of Giant Cells , Arch. Path. 20:665 ( (Nov.) ) 1935. 10. Lever, W. F., and Freiman, D. G.: Sarcoidosis: Report of an Atypical Case with Erythrodermic Lesions, Subcutaneous Nodes and Asteroid Inclusion Bodies in Giant Cells , Arch. Dermat. & Syph. 57:639 ( (April) ) 1948. 11. Cunningham, J. A.: Characteristics of Stellate Inclusions in Giant Cells and the Associated Tissue Reactions , Am. J. Path. 27:761 ( (Sept.) -Oct.) 1951. 12. Arzt, L.: Zur Differentialdiagnose granulomatöser Prozesse (Granulomatosis disciformis chronica progressiva, Nekrobiosis lipoidica diabeticorum, atypisches Tbc-Granulom) , Hautarzt 3:488 ( (Nov.) ) 1952. 13. Dawe, C. J.: The Occurrence of Stellate Inclusion Bodies in Myeloma Cells , Proc. Am. A. Cancer Res. 1:11 ( (April) ) 1953. 14. Jaques, W. E.: Relationship of Asteroid Bodies to Lipids , A. M. A. Arch. Path. 56:68 ( (July) ) 1953. 15. Helman, M. E.: Necrobiosis Lipoidica Diabeticorum , A. M. A. Arch. Dermat. & Syph. 69:386 ( (March) ) 1954. 16. Hildebrand, A. G.; Montgomery, H., and Rynearson, E. H.: Necrobiosis Lipoidica Diabeticorum , Arch. Int. Med. 66:851 ( (Oct.) ) 1940. 17. Laymon, C. W., and Fisher, I.: Necrobiosis Lipoidica (Diabeticorum?): A Histologic Study and Comparison with Granuloma Annulare , Arch. Dermat. & Syph. 59:150 ( (Feb.) ) 1949. 18. Lever, W. F.: Histopathology of the Skin , Ed. 2, Philadelphia, J. B. Lippincott Company, 1954, pp. 190, 192, 269-272. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Asteroid Bodies in Necrobiosis Lipoidica

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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1956.01550090050010
Publisher site
See Article on Publisher Site

Abstract

Abstract Introduction Asteroid bodies are seen not infrequently in dermatopathologic material. These bodies, which have also been called spiculated bodies, radial inclusions, and stellate inclusions in giant cells, have been reported in a variety of pathologic states, including leprosy,1 cryptococcosis,2 a probable case of Weber-Christian disease,3 dermoids, sebaceous cysts, paraffinomas, scars, tuberculosis,4 sarcoid,5 foreign-body granulomas, blastomycosis, various malignancies,6 granulomatosis disciformis chronica et progressiva,7 multiple myeloma,8 cavernous hemangioma, erythema induratum, lipoid pneumonia, diabetes mellitus, and pernicious anemia.9 A review of the literature does not reveal a case of necrobiosis lipoidica associated with asteroid bodies. They have been described in the lung, lymph nodes, liver, spleen, breast, uterus, ovaries, epididymis, and thyroid, as well as in the skin and subcutaneous tissue.9 Obviously, asteroid bodies are not characteristic of any disease. The pathologic alterations in which they are found References 1. References 6 and 9. 2. References 4, 6, and 9. 3. References 4 and 6. 4. Lever, W. F., in discussion on Helman.10 brand, Montgomery, and Rynearson,11 5. References 5 and 13. 6. Mallory, F. B.: The Principles of Pathologic Histology , Philadelphia, W. B. Saunders Company, 1914, pp. 207 and 613. 7. Stoddard, J. L., and Cutler, E. C.: Torula Infection in Man , Monograph 16, Rockefeller Institute for Medical Research, Baltimore, Waverly Press, 1916, p. 55. 8. Görl, P.: Ein Beitrag zur Kasuistik des subcutanen Sarkoids Darier-Roussy , Arch. Dermat. u. Syph. 148:130, 1924.Crossref 9. Hirsch, E. F.: Radial Inclusions of Giant Cells , Arch. Path. 20:665 ( (Nov.) ) 1935. 10. Lever, W. F., and Freiman, D. G.: Sarcoidosis: Report of an Atypical Case with Erythrodermic Lesions, Subcutaneous Nodes and Asteroid Inclusion Bodies in Giant Cells , Arch. Dermat. & Syph. 57:639 ( (April) ) 1948. 11. Cunningham, J. A.: Characteristics of Stellate Inclusions in Giant Cells and the Associated Tissue Reactions , Am. J. Path. 27:761 ( (Sept.) -Oct.) 1951. 12. Arzt, L.: Zur Differentialdiagnose granulomatöser Prozesse (Granulomatosis disciformis chronica progressiva, Nekrobiosis lipoidica diabeticorum, atypisches Tbc-Granulom) , Hautarzt 3:488 ( (Nov.) ) 1952. 13. Dawe, C. J.: The Occurrence of Stellate Inclusion Bodies in Myeloma Cells , Proc. Am. A. Cancer Res. 1:11 ( (April) ) 1953. 14. Jaques, W. E.: Relationship of Asteroid Bodies to Lipids , A. M. A. Arch. Path. 56:68 ( (July) ) 1953. 15. Helman, M. E.: Necrobiosis Lipoidica Diabeticorum , A. M. A. Arch. Dermat. & Syph. 69:386 ( (March) ) 1954. 16. Hildebrand, A. G.; Montgomery, H., and Rynearson, E. H.: Necrobiosis Lipoidica Diabeticorum , Arch. Int. Med. 66:851 ( (Oct.) ) 1940. 17. Laymon, C. W., and Fisher, I.: Necrobiosis Lipoidica (Diabeticorum?): A Histologic Study and Comparison with Granuloma Annulare , Arch. Dermat. & Syph. 59:150 ( (Feb.) ) 1949. 18. Lever, W. F.: Histopathology of the Skin , Ed. 2, Philadelphia, J. B. Lippincott Company, 1954, pp. 190, 192, 269-272.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1956

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