Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Association of the V122I Hereditary Transthyretin Amyloidosis Genetic Variant With Heart Failure Among Individuals of African or Hispanic/Latino Ancestry

Association of the V122I Hereditary Transthyretin Amyloidosis Genetic Variant With Heart Failure... Key PointsQuestionIs there an association between the V122I genetic variant of hereditary transthyretin amyloidosis with heart failure among individuals of African or Hispanic/Latino ancestry? FindingsIn this observational study that included 9694 participants from 2 biobank registries, there was a significant association of the transthyretin V122I genetic variant with heart failure (adjusted odds ratio, 1.7 in a cohort of African ancestry and 1.8 in a separate cohort of African or Hispanic/Latino ancestry). MeaningAmong individuals of African or Hispanic/Latino ancestry, the transthyretin V122I genetic variant was significantly associated with heart failure. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Loading next page...
 
/lp/american-medical-association/association-of-the-v122i-hereditary-transthyretin-amyloidosis-genetic-OPYWzc4jUg
Publisher
American Medical Association
Copyright
Copyright 2019 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2019.17935
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionIs there an association between the V122I genetic variant of hereditary transthyretin amyloidosis with heart failure among individuals of African or Hispanic/Latino ancestry? FindingsIn this observational study that included 9694 participants from 2 biobank registries, there was a significant association of the transthyretin V122I genetic variant with heart failure (adjusted odds ratio, 1.7 in a cohort of African ancestry and 1.8 in a separate cohort of African or Hispanic/Latino ancestry). MeaningAmong individuals of African or Hispanic/Latino ancestry, the transthyretin V122I genetic variant was significantly associated with heart failure.

Journal

JAMAAmerican Medical Association

Published: Dec 10, 2019

References