Key PointsQuestionWhat is the association between perirectal hydrogel spacer placement and clinical outcomes of men receiving radiotherapy for prostate cancer? FindingsThis systematic review and meta-analysis, including results from 7 studies with 1011 patients receiving prostate cancer radiotherapy, found that perirectal hydrogel spacer placement was associated with less rectal irradiation, fewer rectal toxic effects, and higher bowel-related quality of life in long-term follow-up. MeaningPerirectal hydrogel spacer placement prior to prostate radiotherapy may be a prudent preventive strategy for reduction of radiotherapy-induced rectal complications.
JAMA Network Open – American Medical Association
Published: Jun 17, 2020