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Association of Prenatal Exposures of Polybrominated Diphenyl Ethers With Hypospadias

Association of Prenatal Exposures of Polybrominated Diphenyl Ethers With Hypospadias Letters 5. Bloch MH, Mulqueen J. Nutritional supplements for the treatment of ADHD. SbingaandMorrisnotethatourreport isincompleteandpo- Child Adolesc Psychiatr Clin N Am. 2014;23(4):883-897. doi:10.1016/j.chc. tentially biased because we did not discuss the potential benefits 2014.05.002 of dietary supplements, especially ω-3 fatty acids. As the authors 6. Bailey RL, Gahche JJ, Thomas PR, Dwyer JT. Why US children use dietary note, we do reference a study by Chung reporting putative an- supplements. Pediatr Res. 2013;74(6):737-741. doi:10.1038/pr.2013.160 tiarrhythmic effect of ω-3 fatty acids, but these benefits were observed in adults at high cardiovascular risk, not children with- outsuchrisk.Furthermore,a2018systematicreview ofω-3fatty Association of Prenatal Exposures acids for prevention of cardiovascular disease in adults finds a of Polybrominated Diphenyl Ethers higher risk of bias among trials reporting antiarrhythmic benefits With Hypospadias of ω-3 fatty acids than in trials finding potential harms. More- To the Editor WeappreciatetheworkofPoonetal, whichpresent- over,conclusiveevidenceislackingtosupportbenefitofω-3fatty edpolybrominateddiphenylethers(PBDEs)asapotentiallycaus- acids for healthy children including children with ADHD. ative factor for hypospadias. This finding is highly significant be- Our colleagues also describe our use of the term alterna- cause it suggests that appropriate measures could be taken to tive medicines as a misnomer; we agree that this term, as with reduce the risk of developing hypospadias, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Association of Prenatal Exposures of Polybrominated Diphenyl Ethers With Hypospadias

JAMA Pediatrics , Volume 173 (1) – Jan 19, 2019

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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/jamapediatrics.2018.4049
Publisher site
See Article on Publisher Site

Abstract

Letters 5. Bloch MH, Mulqueen J. Nutritional supplements for the treatment of ADHD. SbingaandMorrisnotethatourreport isincompleteandpo- Child Adolesc Psychiatr Clin N Am. 2014;23(4):883-897. doi:10.1016/j.chc. tentially biased because we did not discuss the potential benefits 2014.05.002 of dietary supplements, especially ω-3 fatty acids. As the authors 6. Bailey RL, Gahche JJ, Thomas PR, Dwyer JT. Why US children use dietary note, we do reference a study by Chung reporting putative an- supplements. Pediatr Res. 2013;74(6):737-741. doi:10.1038/pr.2013.160 tiarrhythmic effect of ω-3 fatty acids, but these benefits were observed in adults at high cardiovascular risk, not children with- outsuchrisk.Furthermore,a2018systematicreview ofω-3fatty Association of Prenatal Exposures acids for prevention of cardiovascular disease in adults finds a of Polybrominated Diphenyl Ethers higher risk of bias among trials reporting antiarrhythmic benefits With Hypospadias of ω-3 fatty acids than in trials finding potential harms. More- To the Editor WeappreciatetheworkofPoonetal, whichpresent- over,conclusiveevidenceislackingtosupportbenefitofω-3fatty edpolybrominateddiphenylethers(PBDEs)asapotentiallycaus- acids for healthy children including children with ADHD. ative factor for hypospadias. This finding is highly significant be- Our colleagues also describe our use of the term alterna- cause it suggests that appropriate measures could be taken to tive medicines as a misnomer; we agree that this term, as with reduce the risk of developing hypospadias,

Journal

JAMA PediatricsAmerican Medical Association

Published: Jan 19, 2019

References