Key PointsQuestionDoes the use of topical corticosteroids cause systemic adverse events such as those seen with use of systemic corticosteroids? FindingsIn a cohort study of 723 251 users of potent or very potent topical corticosteroids, use of these drugs was associated with increased risk of osteoporosis and major osteoporotic fracture with a dose-response association for cumulative use. MeaningBased on these findings, clinicians may need to consider other corticosteroid-sparing therapeutic options for people requiring potent anti-inflammatory treatment on large body surfaces for prolonged periods to limit the risk of osteoporosis.
JAMA Dermatology – American Medical Association
Published: Mar 20, 2021