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Association of Naturalistic Administration of Cannabis Flower and Concentrates With Intoxication and Impairment

Association of Naturalistic Administration of Cannabis Flower and Concentrates With Intoxication... Key PointsQuestionWhat is the association of legal market cannabis flower and concentrates with cannabis intoxication and neurobehavioral impairment? FindingsIn this cohort study of 121 cannabis flower users and concentrate users randomly assigned to higher- vs lower-THC products within user groups, use of legal market cannabis concentrates (ranging from 70%-90% tetrahydrocannabinol [THC]) produced significantly higher THC blood plasma levels compared with use of legal market cannabis flower (ranging from 16%-24% THC). Despite differences in THC exposure, flower and concentrate users showed similar neurobehavioral patterns after acute cannabis use and the domains of verbal memory and proprioception-focused postural stability for both groups were associated with THC. MeaningUse of cannabis concentrates was associated with higher THC exposure and potentially greater risk, but differences in short-term subjective and neurobehavioral impairments did not track specifically with strength of the cannabis consumed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Association of Naturalistic Administration of Cannabis Flower and Concentrates With Intoxication and Impairment

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Publisher
American Medical Association
Copyright
Copyright 2020 American Medical Association. All Rights Reserved.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/jamapsychiatry.2020.0927
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionWhat is the association of legal market cannabis flower and concentrates with cannabis intoxication and neurobehavioral impairment? FindingsIn this cohort study of 121 cannabis flower users and concentrate users randomly assigned to higher- vs lower-THC products within user groups, use of legal market cannabis concentrates (ranging from 70%-90% tetrahydrocannabinol [THC]) produced significantly higher THC blood plasma levels compared with use of legal market cannabis flower (ranging from 16%-24% THC). Despite differences in THC exposure, flower and concentrate users showed similar neurobehavioral patterns after acute cannabis use and the domains of verbal memory and proprioception-focused postural stability for both groups were associated with THC. MeaningUse of cannabis concentrates was associated with higher THC exposure and potentially greater risk, but differences in short-term subjective and neurobehavioral impairments did not track specifically with strength of the cannabis consumed.

Journal

JAMA PsychiatryAmerican Medical Association

Published: Aug 10, 2020

References