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Association of Marine Omega-3 Fatty Acid Levels With Telomeric Aging in Patients With Coronary Heart Disease

Association of Marine Omega-3 Fatty Acid Levels With Telomeric Aging in Patients With Coronary... ORIGINAL CONTRIBUTION Association of Marine Omega-3 Fatty Acid Levels With Telomeric Aging in Patients With Coronary Heart Disease Ramin Farzaneh-Far, MD Context Increased dietary intake of marine omega-3 fatty acids is associated with Jue Lin, PhD prolonged survival in patients with coronary heart disease. However, the mechanisms underlying this protective effect are poorly understood. Elissa S. Epel, PhD Objective To investigate the association of omega-3 fatty acid blood levels with tem- William S. Harris, PhD poral changes in telomere length, an emerging marker of biological age. Elizabeth H. Blackburn, PhD Design, Setting, and Participants Prospective cohort study of 608 ambulatory Mary A. Whooley, MD outpatients in California with stable coronary artery disease recruited from the Heart and Soul Study between September 2000 and December 2002 and followed up to ULTIPLE EPIDEMIOLOGIC January 2009 (median, 6.0 years; range, 5.0-8.1 years). studies, including sev- Main Outcome Measures We measured leukocyte telomere length at baseline eral large randomized and again after 5 years of follow-up. Multivariable linear and logistic regression mod- Mcontrolled trials, have els were used to investigate the association of baseline levels of omega-3 fatty acids demonstrated higher survival rates (docosahexaenoic acid [DHA] and eicosapentaenoic acid [EPA]) with subsequent change http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Association of Marine Omega-3 Fatty Acid Levels With Telomeric Aging in Patients With Coronary Heart Disease

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Publisher
American Medical Association
Copyright
Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2009.2008
pmid
20085953
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Association of Marine Omega-3 Fatty Acid Levels With Telomeric Aging in Patients With Coronary Heart Disease Ramin Farzaneh-Far, MD Context Increased dietary intake of marine omega-3 fatty acids is associated with Jue Lin, PhD prolonged survival in patients with coronary heart disease. However, the mechanisms underlying this protective effect are poorly understood. Elissa S. Epel, PhD Objective To investigate the association of omega-3 fatty acid blood levels with tem- William S. Harris, PhD poral changes in telomere length, an emerging marker of biological age. Elizabeth H. Blackburn, PhD Design, Setting, and Participants Prospective cohort study of 608 ambulatory Mary A. Whooley, MD outpatients in California with stable coronary artery disease recruited from the Heart and Soul Study between September 2000 and December 2002 and followed up to ULTIPLE EPIDEMIOLOGIC January 2009 (median, 6.0 years; range, 5.0-8.1 years). studies, including sev- Main Outcome Measures We measured leukocyte telomere length at baseline eral large randomized and again after 5 years of follow-up. Multivariable linear and logistic regression mod- Mcontrolled trials, have els were used to investigate the association of baseline levels of omega-3 fatty acids demonstrated higher survival rates (docosahexaenoic acid [DHA] and eicosapentaenoic acid [EPA]) with subsequent change

Journal

JAMAAmerican Medical Association

Published: Jan 20, 2010

References