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Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women

Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident... Key PointsQuestionDo risk profiles for coronary heart disease differ by age at onset? FindingsIn this cohort study including 28 024 women, associations of most risk factors with coronary heart disease attenuated with increasing age at onset. Of more than 50 clinical and biomarker risk factors examined, diabetes and lipoprotein insulin resistance had the highest relative risk, particularly for premature coronary heart disease; some risk factors (eg, inactivity, lipoprotein[a]) had similar associations by age at onset, and others had no association with coronary heart disease onset at any age. MeaningRisk profiles appear to differ by age at coronary heart disease onset in women, with the greatest risk for premature events associated with diabetes and insulin resistance. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Cardiology American Medical Association

Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women

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Publisher
American Medical Association
Copyright
Copyright 2021 American Medical Association. All Rights Reserved.
ISSN
2380-6583
eISSN
2380-6591
DOI
10.1001/jamacardio.2020.7073
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionDo risk profiles for coronary heart disease differ by age at onset? FindingsIn this cohort study including 28 024 women, associations of most risk factors with coronary heart disease attenuated with increasing age at onset. Of more than 50 clinical and biomarker risk factors examined, diabetes and lipoprotein insulin resistance had the highest relative risk, particularly for premature coronary heart disease; some risk factors (eg, inactivity, lipoprotein[a]) had similar associations by age at onset, and others had no association with coronary heart disease onset at any age. MeaningRisk profiles appear to differ by age at coronary heart disease onset in women, with the greatest risk for premature events associated with diabetes and insulin resistance.

Journal

JAMA CardiologyAmerican Medical Association

Published: Apr 20, 2021

References