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Association of LDL Cholesterol, Non–HDL Cholesterol, and Apolipoprotein B Levels With Risk of Cardiovascular Events Among Patients Treated With Statins

Association of LDL Cholesterol, Non–HDL Cholesterol, and Apolipoprotein B Levels With Risk of... REVIEW CLINICIAN’S CORNER Association of LDL Cholesterol, Non–HDL Cholesterol, and Apolipoprotein B Levels With Risk of Cardiovascular Events Among Patients Treated With Statins A Meta-analysis S. Matthijs Boekholdt, MD, PhD Context The associations of low-density lipoprotein cholesterol (LDL-C), non–high- Benoit J. Arsenault, PhD density lipoprotein cholesterol (non–HDL-C), and apolipoprotein B (apoB) levels with the risk of cardiovascular events among patients treated with statin therapy have not Samia Mora, MD, MHS been reliably documented. Terje R. Pedersen, MD, PhD Objective To evaluate the relative strength of the associations of LDL-C, non– John C. LaRosa, MD HDL-C, and apoB with cardiovascular risk among patients treated with statin therapy. Paul J. Nestel, MD Design Meta-analysis of individual patient data from randomized controlled statin trials in which conventional lipids and apolipoproteins were determined in all study R. John Simes, MD participants at baseline and at 1-year follow-up. Paul Durrington, MD Data Sources Relevant trials were identified by a literature search updated through Graham A. Hitman, MD December 31, 2011. Investigators were contacted and individual patient data were K. M. A. Welch, MB, ChB requested and obtained for 62154 patients enrolled in 8 trials published between 1994 and 2008. David A. DeMicco, DPharm Data http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2012.366
pmid
22453571
Publisher site
See Article on Publisher Site

Abstract

REVIEW CLINICIAN’S CORNER Association of LDL Cholesterol, Non–HDL Cholesterol, and Apolipoprotein B Levels With Risk of Cardiovascular Events Among Patients Treated With Statins A Meta-analysis S. Matthijs Boekholdt, MD, PhD Context The associations of low-density lipoprotein cholesterol (LDL-C), non–high- Benoit J. Arsenault, PhD density lipoprotein cholesterol (non–HDL-C), and apolipoprotein B (apoB) levels with the risk of cardiovascular events among patients treated with statin therapy have not Samia Mora, MD, MHS been reliably documented. Terje R. Pedersen, MD, PhD Objective To evaluate the relative strength of the associations of LDL-C, non– John C. LaRosa, MD HDL-C, and apoB with cardiovascular risk among patients treated with statin therapy. Paul J. Nestel, MD Design Meta-analysis of individual patient data from randomized controlled statin trials in which conventional lipids and apolipoproteins were determined in all study R. John Simes, MD participants at baseline and at 1-year follow-up. Paul Durrington, MD Data Sources Relevant trials were identified by a literature search updated through Graham A. Hitman, MD December 31, 2011. Investigators were contacted and individual patient data were K. M. A. Welch, MB, ChB requested and obtained for 62154 patients enrolled in 8 trials published between 1994 and 2008. David A. DeMicco, DPharm Data

Journal

JAMAAmerican Medical Association

Published: Mar 28, 2012

References