CLINICAL SCIENCES Association of Inflammatory Factors With Macular Edema in Branch Retinal Vein Occlusion Hidetaka Noma, MD; Tatsuya Mimura, MD; Shuichiro Eguchi, MD Objective: To evaluate the association between vitre- higher in the patients with BRVO than in those with MH; ous fluid levels of inflammatory factors and macular edema however, the PEDF level was significantly lower in the in patients with branch retinal vein occlusion (BRVO). BRVO group. Vitreous fluid levels of all 7 factors were significantly correlated with the retinal thickness at the Methods: In 39 patients with BRVO and macular edema central fovea. There were also significant correlations of and 21 individuals with idiopathic macular hole (MH) serv- sVEGFR-2 with sICAM-1, IL-6, MCP-1, and PTX3 but ing as controls, vitreous fluid samples were obtained dur- no correlation with VEGF. However, there were signifi- ing vitreoretinal surgery, and the levels of vascular endo- cant correlations of VEGF with sICAM-1, IL-6, MCP-1, thelial growth factor (VEGF), soluble VEGF receptor 2 and PEDF in the BRVO group. (sVEGFR-2), soluble intercellular adhesion molecule 1 (sICAM-1), interleukin 6 (IL-6), monocyte chemotactic pro- Conclusions: Vitreous fluid levels of sVEGFR-2, VEGF, tein 1 (MCP-1), pentraxin 3 (PTX3), and pigment epithe- sICAM-1, IL-6, MCP-1,
JAMA Ophthalmology – American Medical Association
Published: Feb 1, 2013
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