Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Association of Inflammatory Factors With Macular Edema in Branch Retinal Vein Occlusion

Association of Inflammatory Factors With Macular Edema in Branch Retinal Vein Occlusion CLINICAL SCIENCES Association of Inflammatory Factors With Macular Edema in Branch Retinal Vein Occlusion Hidetaka Noma, MD; Tatsuya Mimura, MD; Shuichiro Eguchi, MD Objective: To evaluate the association between vitre- higher in the patients with BRVO than in those with MH; ous fluid levels of inflammatory factors and macular edema however, the PEDF level was significantly lower in the in patients with branch retinal vein occlusion (BRVO). BRVO group. Vitreous fluid levels of all 7 factors were significantly correlated with the retinal thickness at the Methods: In 39 patients with BRVO and macular edema central fovea. There were also significant correlations of and 21 individuals with idiopathic macular hole (MH) serv- sVEGFR-2 with sICAM-1, IL-6, MCP-1, and PTX3 but ing as controls, vitreous fluid samples were obtained dur- no correlation with VEGF. However, there were signifi- ing vitreoretinal surgery, and the levels of vascular endo- cant correlations of VEGF with sICAM-1, IL-6, MCP-1, thelial growth factor (VEGF), soluble VEGF receptor 2 and PEDF in the BRVO group. (sVEGFR-2), soluble intercellular adhesion molecule 1 (sICAM-1), interleukin 6 (IL-6), monocyte chemotactic pro- Conclusions: Vitreous fluid levels of sVEGFR-2, VEGF, tein 1 (MCP-1), pentraxin 3 (PTX3), and pigment epithe- sICAM-1, IL-6, MCP-1, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Ophthalmology American Medical Association

Association of Inflammatory Factors With Macular Edema in Branch Retinal Vein Occlusion

Download PDF
6 pages
Read Article

Loading next page...
 
/lp/american-medical-association/association-of-inflammatory-factors-with-macular-edema-in-branch-lVX9tyIb3f
Publisher
American Medical Association
Copyright
Copyright 2013 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6165
eISSN
2168-6173
DOI
10.1001/2013.jamaophthalmol.228
pmid
23411880
Publisher site
See Article on Publisher Site

Abstract

CLINICAL SCIENCES Association of Inflammatory Factors With Macular Edema in Branch Retinal Vein Occlusion Hidetaka Noma, MD; Tatsuya Mimura, MD; Shuichiro Eguchi, MD Objective: To evaluate the association between vitre- higher in the patients with BRVO than in those with MH; ous fluid levels of inflammatory factors and macular edema however, the PEDF level was significantly lower in the in patients with branch retinal vein occlusion (BRVO). BRVO group. Vitreous fluid levels of all 7 factors were significantly correlated with the retinal thickness at the Methods: In 39 patients with BRVO and macular edema central fovea. There were also significant correlations of and 21 individuals with idiopathic macular hole (MH) serv- sVEGFR-2 with sICAM-1, IL-6, MCP-1, and PTX3 but ing as controls, vitreous fluid samples were obtained dur- no correlation with VEGF. However, there were signifi- ing vitreoretinal surgery, and the levels of vascular endo- cant correlations of VEGF with sICAM-1, IL-6, MCP-1, thelial growth factor (VEGF), soluble VEGF receptor 2 and PEDF in the BRVO group. (sVEGFR-2), soluble intercellular adhesion molecule 1 (sICAM-1), interleukin 6 (IL-6), monocyte chemotactic pro- Conclusions: Vitreous fluid levels of sVEGFR-2, VEGF, tein 1 (MCP-1), pentraxin 3 (PTX3), and pigment epithe- sICAM-1, IL-6, MCP-1,

Journal

JAMA Ophthalmology – American Medical Association

Published: Feb 1, 2013

References

  • In vivo evaluation of leukocyte dynamics in retinal ischemia reperfusion injury.
    Tsujikawa, A; Ogura, Y; Hiroshiba, N; Miyamoto, K; Kiryu, J; Honda, Y
  • A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with standard care to treat vision loss associated with macular edema secondary to branch retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study report 6.
    Scott, IU; Ip, MS; VanVeldhuisen, PC
  • Blood-aqueous barrier in eyes with retinal vein occlusion.
    Miyake, K; Miyake, T; Kayazawa, F
  • Visual prognosis and vitreous molecules after vitrectomy for macular edema with branch retinal vein occlusion.
    Noma, H; Funatsu, H; Mimura, T; Eguchi, S; Shimada, K
  • VEGF increases retinal vascular ICAM-1 expression in vivo.
    Lu, M; Perez, VL; Ma, N
  • Pigment epithelium–derived factor (PEDF) is an endogenous antiinflammatory factor.
    Zhang, SX; Wang, JJ; Gao, G; Shao, C; Mott, R; Ma, JX
  • Comprehensive analysis of inflammatory immune mediators in vitreoretinal diseases.
    Yoshimura, T; Sonoda, KH; Sugahara, M
  • Intravitreal levels of vascular endothelial growth factor and interleukin-6 are correlated with macular edema in branch retinal vein occlusion.
    Noma, H; Minamoto, A; Funatsu, H
  • Pigment epithelium-derived factor and vascular endothelial growth factor in branch retinal vein occlusion with macular edema.
    Noma, H; Funatsu, H; Mimura, T; Harino, S; Eguchi, S; Hori, S
  • Soluble vascular endothelial growth factor receptor-2 and inflammatory factors in macular edema with branch retinal vein occlusion.
    Noma, H; Funatsu, H; Mimura, T; Eguchi, S; Hori, S
  • Multivariate analyses of inflammatory cytokines in eyes with branch retinal vein occlusion: relationships to bevacizumab treatment.
    Kaneda, S; Miyazaki, D; Sasaki, S
  • PTX3, a prototypical long pentraxin, is an early indicator of acute myocardial infarction in humans.
    Peri, G; Introna, M; Corradi, D
  • Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction.
    Latini, R; Maggioni, AP; Peri, G
  • Interleukin-1–inducible genes in endothelial cells: cloning of a new gene related to C-reactive protein and serum amyloid P component.
    Breviario, F; d’Aniello, EM; Golay, J
  • Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility.
    Garlanda, C; Bottazzi, B; Bastone, A; Mantovani, A
  • Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes.
    Alles, VV; Bottazzi, B; Peri, G; Golay, J; Introna, M; Mantovani, A
  • Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites.
    Introna, M; Alles, VV; Castellano, M
  • Differential regulation of TSG-14 expression in murine fibroblasts and peritoneal macrophages.
    Goodman, AR; Levy, DE; Reis, LF; Vilcek, J
  • Production of the soluble pattern recognition receptor PTX3 by myeloid, but not plasmacytoid, dendritic cells.
    Doni, A; Peri, G; Chieppa, M
  • Modified atherogenic lipoproteins induce expression of pentraxin-3 by human vascular smooth muscle cells.
    Klouche, M; Peri, G; Knabbe, C
  • Synergistic trans-activation of the human C-reactive protein promoter by transcription factor HNF-1 binding at two distinct sites.
    Toniatti, C; Demartis, A; Monaci, P; Nicosia, A; Ciliberto, G
  • C-reactive protein: a critical update.
    Pepys, MB; Hirschfield, GM
  • Increased mortality and inflammation in tumor necrosis factor–stimulated gene-14 transgenic mice after ischemia and reperfusion injury.
    Souza, DG; Soares, AC; Pinho, V
  • The long pentraxin PTX3 is crucial for tissue inflammation after intestinal ischemia and reperfusion in mice.
    Souza, DG; Amaral, FA; Fagundes, CT
  • Argon laser photocoagulation for macular edema in branch vein occlusion.
  • Tomographic assessment of vitreous surgery for diabetic macular edema.
    Otani, T; Kishi, S
  • Surgical posterior vitreous detachment combined with gas/air tamponade for treating macular edema associated with branch retinal vein occlusion: retinal tomography and visual outcome.
    Saika, S; Tanaka, T; Miyamoto, T; Ohnishi, Y
  • Vitrectomy prevents retinal hypoxia in branch retinal vein occlusion.
    Stefánsson, E; Novack, RL; Hatchell, DL
  • Ocular oxygenation and the treatment of diabetic retinopathy.
    Stefánsson, E
  • Relation of intraocular concentrations of inflammatory factors and improvement of macular edema after vitrectomy in branch retinal vein occlusion.
    Okunuki, Y; Usui, Y; Katai, N
  • Vitrectomy with or without arteriovenous adventitial sheathotomy for macular edema associated with branch retinal vein occlusion.
    Yamamoto, S; Saito, W; Yagi, F; Takeuchi, S; Sato, E; Mizunoya, S
  • Long-term outcomes of vitrectomy with or without arteriovenous sheathotomy in branch retinal vein occlusion.
    Kumagai, K; Furukawa, M; Ogino, N; Uemura, A; Larson, E
  • Association of vitreous inflammatory factors with diabetic macular edema.
    Funatsu, H; Noma, H; Mimura, T; Eguchi, S; Hori, S
  • Regulation of leukocyte recruitment by the long pentraxin PTX3.
    Deban, L; Russo, RC; Sironi, M
  • Vascular endothelial growth factor (VEGF)–induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1).
    Miyamoto, K; Khosrof, S; Bursell, SE
  • VEGF164 is proinflammatory in the diabetic retina.
    Ishida, S; Usui, T; Yamashiro, K
  • Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth.
    Xia, P; Aiello, LP; Ishii, H
  • Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c-Src.
    He, H; Venema, VJ; Gu, X; Venema, RC; Marrero, MB; Caldwell, RB
  • Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation.
    Wu, LW; Mayo, LD; Dunbar, JD
  • Platelet-derived growth factor–induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCγ.
    Olivera, A; Edsall, L; Poulton, S; Kazlauskas, A; Spiegel, S
  • Activation in vitro of NF-κB by phosphorylation of its inhibitor IκB.
    Ghosh, S; Baltimore, D
  • Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.
    Matsusaka, T; Fujikawa, K; Nishio, Y
  • Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells: essential roles of a variant NF-κB site and p65 homodimers.
    Ledebur, HC; Parks, TP
  • Inhibition of endothelial cell activation by adenovirus-mediated expression of IκBα, an inhibitor of the transcription factor NF-κB.
    Wrighton, CJ; Hofer-Warbinek, R; Moll, T; Eytner, R; Bach, FH; de Martin, R
  • The NF-κB and IκB proteins: new discoveries and insights.
    Baldwin, AS
  • Platelet-derived growth factor–stimulated superoxide anion production modulates activation of transcription factor NF-κB and expression of monocyte chemoattractant protein 1 in human aortic smooth muscle cells.
    Marumo, T; Schini-Kerth, VB; Fisslthaler, B; Busse, R
  • Inhibition of nuclear factor-κB nuclear localization reduces human E-selectin expression and the systemic inflammatory response.
    Boyle, EM; Kovacich, JC; Canty, TG
  • Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases.
    Barnes, PJ; Karin, M
  • NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses.
    Ghosh, S; May, MJ; Kopp, EB
  • Integrating cell-signalling pathways with NF-κB and IKK function.
    Perkins, ND
  • Protein kinase C β is required for human monocyte chemotaxis to MCP-1.
    Carnevale, KA; Cathcart, MK
  • Monocyte chemoattractant protein-1–induced angiogenesis is mediated by vascular endothelial growth factor-A.
    Hong, KH; Ryu, J; Han, KH
  • Soluble Flt-1gene transfer ameliorates neointima formation after wire injury in flt-1 tyrosine kinase–deficient mice.
    Koga, J; Matoba, T; Egashira, K
  • Vascular endothelial growth factor induces protein kinase D–dependent production of proinflammatory cytokines in endothelial cells.
    Hao, Q; Wang, L; Tang, H
  • Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-κB activation in endothelial cells.
    Kim, I; Moon, SO; Kim, SH; Kim, HJ; Koh, YS; Koh, GY
  • Interleukin-6 triggers human cerebral endothelial cells proliferation and migration: the role for KDR and MMP-9.
    Yao, JS; Zhai, W; Young, WL; Yang, GY
  • Characterization of the promoter for the human long pentraxin PTX3: role of NF-κB in tumor necrosis factor–α and interleukin-1β regulation.
    Basile, A; Sica, A; d’Aniello, E
  • The biology of vascular endothelial growth factor.
    Ferrara, N; Davis-Smyth, T
  • Signal transduction by vascular endothelial growth factor receptors.
    Claesson-Welsh, L
  • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1.
    Forsythe, JA; Jiang, BH; Iyer, NV
  • Transcriptional regulation of the vascular endothelial growth factor gene—a concert of activating factors.
    Pagès, G; Pouysségur, J
  • Aqueous humour levels of cytokines are correlated to vitreous levels and severity of macular oedema in branch retinal vein occlusion.
    Noma, H; Funatsu, H; Yamasaki, M

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

Sign up
for free
Start 14 day
Free Trial