Abstract We compared prior pregnancy histories of two groups of multigravidas—240 women having a pregnancy loss up to 28 weeks' gestation and 1,072 women having a term delivery. Women who had had two or more prior induced abortions had a twofold to threefold increase in risk of first-trimester spontaneous abortion, loss between 14 to 19 and 20 to 27 weeks. The increased risk was present for women who had legal induced abortions since 1973. It was not explained by smoking status, history of prior spontaneous loss, prior abortion method, or degree of cervical dilatation. No increase in risk of pregnancy loss was detected among women with a single prior induced abortion. We conclude that multiple induced abortions do increase the risk of subsequent pregnancy losses up to 28 weeks' gestation. (JAMA 243:2495-2499, 1980) References 1. Alberman E, Elliott M, Creasy M, et al: Previous reproductive history in mothers presenting with spontaneous abortions . Br J Obstet Gynecol 82:366-373, 1975.Crossref 2. Kline J, Stein Z, Susser M, et al: Induced abortion and spontaneous abortion: No connection? Am J Epidemiol 107:290-298, 1978. 3. Harlap S, Shiono PH, Ramcharan S, et al: A prospective study of spontaneous fetal losses after induced abortions . N Engl J Med 301:677-681, 1979.Crossref 4. Mantel N, Haenszel W: Statistical aspects of the analysis of data from retrospective studies of disease . J Natl Cancer Inst 22:719-748, 1959. 5. Miettinen OS: Stratification by a multivariate confounder score . Am J Epidemiol 104:609-620, 1976. 6. Wright CSW, Campbell S, Beazley J: Second-trimester abortion after vaginal termination of pregnancy . Lancet 1:1278-1279, 1972.Crossref 7. Richardson JA, Dixon G: Effects of legal termination of subsequent pregnancy . Br Med J 1:1303-1304, 1976.Crossref 8. Moriyama Y, Hirokawa 0: The relationship between artificial termination of pregnancy and abortion of premature birth , in Harmful Effects of Induced Abortion . Tokyo, Family Planning Federation of Japan, 1966, pp 64-73. 9. Schoenbaum SC, Monson RR, Stubblefield PG, et al: Outcome of the delivery following an induced or spontaneous abortion . Am J Obstet Gynecol 136:19-24, 1980. 10. Harlap S, Davies AM: Late sequelae of induced abortion: Complications and outcome of pregnancy and labor . Am J Epidemiol 102:217-224, 1975. 11. Gestation, birth-weight and spontaneous abortion in pregnancy after induced abortion, WHO Task Force on Sequelae of Abortion . Lancet 1:142-145, 1979. 12. Roht LH, Aoyama H, Leinen GE, et al: The association of multiple induced abortions with subsequent prematurity and spontaneous abortion . Acta Obstet Gynaecol Jpn 23:140-145, 1976. 13. Daling JR, Emanuel I: Induced abortion and subsequent outcome of pregnancy . Lancet 2:170-172, 1975.Crossref 14. Daling JR, Emanuel I: Induced abortion and subsequent outcome of pregnancy in a series of American women . N Engl J Med 297:1241-1245, 1977.Crossref 15. Hogue CJ: Low birth weight subsequent to induced abortion: A historical prospective study of 948 women in Skopje, Yugoslavia . Am J Obstet Gynecol 123:675-681, 1975. 16. Koller O, Eikhom SN: Late sequelae of induced abortion in primigravidae: The outcome of the subsequent pregnancies . Acta Obstet Gynecol Scand 56:311-317, 1977.Crossref 17. Van der Slikke JW, Treffers PE: Influence of induced abortion on gestational duration in subsequent pregnancies . Br Med J 1:270-272, 1978.Crossref
JAMA – American Medical Association
Published: Jun 27, 1980
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