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Association of Genetic Variants With Warfarin-Associated Bleeding Among Patients of African Descent

Association of Genetic Variants With Warfarin-Associated Bleeding Among Patients of African Descent Key PointsQuestionAre specific single-nucleotide polymorphisms (SNPs) associated with increased risk of warfarin-associated bleeding among patients of African descent? FindingsIn this case-control genome-wide association study involving patients of African descent taking warfarin with an international normalized ratio of less than 4, four SNPs in linkage disequilibrium on chromosome 6 were associated with an increased risk of major bleeding in a discovery cohort of 215 patients (odds ratio [OR], 8.3) and a replication cohort of 188 patients (OR, 8.2), and reached genome-wide significance when the cohorts were combined using meta-analysis (OR, 8.3). MeaningFour single-nucleotide polymorphisms in linkage disequilibrium on chromosome 6 were associated with an increased risk of major bleeding among patients of African descent taking warfarin; however, validation of these findings in an independent prospective cohort is required. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Association of Genetic Variants With Warfarin-Associated Bleeding Among Patients of African Descent

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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2018.14955
pmid
30357299
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionAre specific single-nucleotide polymorphisms (SNPs) associated with increased risk of warfarin-associated bleeding among patients of African descent? FindingsIn this case-control genome-wide association study involving patients of African descent taking warfarin with an international normalized ratio of less than 4, four SNPs in linkage disequilibrium on chromosome 6 were associated with an increased risk of major bleeding in a discovery cohort of 215 patients (odds ratio [OR], 8.3) and a replication cohort of 188 patients (OR, 8.2), and reached genome-wide significance when the cohorts were combined using meta-analysis (OR, 8.3). MeaningFour single-nucleotide polymorphisms in linkage disequilibrium on chromosome 6 were associated with an increased risk of major bleeding among patients of African descent taking warfarin; however, validation of these findings in an independent prospective cohort is required.

Journal

JAMA – American Medical Association

Published: Oct 23, 2018

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