Key PointsQuestionAre specific single-nucleotide polymorphisms (SNPs) associated with increased risk of warfarin-associated bleeding among patients of African descent? FindingsIn this case-control genome-wide association study involving patients of African descent taking warfarin with an international normalized ratio of less than 4, four SNPs in linkage disequilibrium on chromosome 6 were associated with an increased risk of major bleeding in a discovery cohort of 215 patients (odds ratio [OR], 8.3) and a replication cohort of 188 patients (OR, 8.2), and reached genome-wide significance when the cohorts were combined using meta-analysis (OR, 8.3). MeaningFour single-nucleotide polymorphisms in linkage disequilibrium on chromosome 6 were associated with an increased risk of major bleeding among patients of African descent taking warfarin; however, validation of these findings in an independent prospective cohort is required.
JAMA – American Medical Association
Published: Oct 23, 2018
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