Association of Filaggrin Loss-of-Function Variants With Race in Children With Atopic Dermatitis

Association of Filaggrin Loss-of-Function Variants With Race in Children With Atopic Dermatitis Key PointsQuestionDo FLG loss-of-function variants differ between African American and white children with atopic dermatitis? FindingsIn a registry cohort of 741 children with atopic dermatitis, FLG loss-of-function variants differed significantly by race, were associated with race, and overall differences were noted with respect to whether any variant was present as well as the frequency of individual variants. MeaningThese findings suggest that using FLG loss-of-function variants to diagnose atopic dermatitis or to estimate the clinical course may be very difficult because very common variants in one race may be absent or very rare in another. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

Association of Filaggrin Loss-of-Function Variants With Race in Children With Atopic Dermatitis

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Publisher
American Medical Association
Copyright
Copyright 2019 American Medical Association. All Rights Reserved.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/jamadermatol.2019.1946
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionDo FLG loss-of-function variants differ between African American and white children with atopic dermatitis? FindingsIn a registry cohort of 741 children with atopic dermatitis, FLG loss-of-function variants differed significantly by race, were associated with race, and overall differences were noted with respect to whether any variant was present as well as the frequency of individual variants. MeaningThese findings suggest that using FLG loss-of-function variants to diagnose atopic dermatitis or to estimate the clinical course may be very difficult because very common variants in one race may be absent or very rare in another.

Journal

JAMA DermatologyAmerican Medical Association

Published: Dec 1, 2019

References

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