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Association of Dermatitis Herpetiformis and Pernicious Anemia

Association of Dermatitis Herpetiformis and Pernicious Anemia Abstract Dermatitis herpetiformis is a chronic disease of uncertain, but possibly autoimmune, cause. It is characterized by symmetrically distributed clusters of papules and vesicles, most notably over the extensor surfaces of the extremities, buttocks, and shoulders. Much has been written about the association between dermatitis herpetiformis (DH) and gluten-sensitive enteropathy or celiac disease, but little has been said regarding a possible association between DH and other gastrointestinal disease. We describe herein a patient with pernicious anemia (PA) in whom DH developed after the patient had had the former disease for several years. A brief review of the literature linking the two diseases is presented. Report of a Case A 59-year-old man was admitted to the Veterans Administration Hospital in Tucson, Ariz, in April 1965, with a macrocytic anemia. At that time, a Schilling test was performed and the patient was noted to have extremely low excretion of vitamin B12 (0.23%) References 1. Ilyas M: Malabsorption with dermatitis herpetiformis . Lancet 1:248-249, 1968.Crossref 2. Cream JJ, Scott GL: Anemia in dermatitis herpetiformis . Br J Dermatol 82:333-342, 1970.Crossref 3. Fraser HG: Autoantibodies in dermatitis herpetiformis . Br J Dermatol 83:609-613, 1970.Crossref 4. Andersson H, Dotevall G, Mobacken H: Gastric secretion of acid and intrinsic factor in dermatitis herpetiformis . Scand J Gastroenterol 6:411-416, 1971.Crossref 5. Lancaster-Smith M, O'Donoghue P, Kumar PJ: Abnormalities of gastric morphology and acid secretion in patients with dermatitis herpetiformis . Gut 16:683-688, 1975.Crossref 6. O'Donoghue P, Lancaster-Smith M, Johnson GD, et al: Gastric lesion in dermatitis herpetiformis . Gut 17:185-188, 1976.Crossref 7. Davies MG, Marks R, Nuki G: Dermatitis herpetiformis: A skin manifestation of a generalized disturbance in immunity . Q J Med 186:221-248, 1978. 8. Katz SI, Strober W: The pathogenesis of dermatitis herpetiformis . J Invest Dermatol 70:63-75, 1978.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Association of Dermatitis Herpetiformis and Pernicious Anemia

Archives of Dermatology , Volume 115 (9) – Sep 1, 1979

Association of Dermatitis Herpetiformis and Pernicious Anemia

Abstract

Abstract Dermatitis herpetiformis is a chronic disease of uncertain, but possibly autoimmune, cause. It is characterized by symmetrically distributed clusters of papules and vesicles, most notably over the extensor surfaces of the extremities, buttocks, and shoulders. Much has been written about the association between dermatitis herpetiformis (DH) and gluten-sensitive enteropathy or celiac disease, but little has been said regarding a possible association between DH and other...
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Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1979.04010090059028
Publisher site
See Article on Publisher Site

Abstract

Abstract Dermatitis herpetiformis is a chronic disease of uncertain, but possibly autoimmune, cause. It is characterized by symmetrically distributed clusters of papules and vesicles, most notably over the extensor surfaces of the extremities, buttocks, and shoulders. Much has been written about the association between dermatitis herpetiformis (DH) and gluten-sensitive enteropathy or celiac disease, but little has been said regarding a possible association between DH and other gastrointestinal disease. We describe herein a patient with pernicious anemia (PA) in whom DH developed after the patient had had the former disease for several years. A brief review of the literature linking the two diseases is presented. Report of a Case A 59-year-old man was admitted to the Veterans Administration Hospital in Tucson, Ariz, in April 1965, with a macrocytic anemia. At that time, a Schilling test was performed and the patient was noted to have extremely low excretion of vitamin B12 (0.23%) References 1. Ilyas M: Malabsorption with dermatitis herpetiformis . Lancet 1:248-249, 1968.Crossref 2. Cream JJ, Scott GL: Anemia in dermatitis herpetiformis . Br J Dermatol 82:333-342, 1970.Crossref 3. Fraser HG: Autoantibodies in dermatitis herpetiformis . Br J Dermatol 83:609-613, 1970.Crossref 4. Andersson H, Dotevall G, Mobacken H: Gastric secretion of acid and intrinsic factor in dermatitis herpetiformis . Scand J Gastroenterol 6:411-416, 1971.Crossref 5. Lancaster-Smith M, O'Donoghue P, Kumar PJ: Abnormalities of gastric morphology and acid secretion in patients with dermatitis herpetiformis . Gut 16:683-688, 1975.Crossref 6. O'Donoghue P, Lancaster-Smith M, Johnson GD, et al: Gastric lesion in dermatitis herpetiformis . Gut 17:185-188, 1976.Crossref 7. Davies MG, Marks R, Nuki G: Dermatitis herpetiformis: A skin manifestation of a generalized disturbance in immunity . Q J Med 186:221-248, 1978. 8. Katz SI, Strober W: The pathogenesis of dermatitis herpetiformis . J Invest Dermatol 70:63-75, 1978.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1979

References