Key PointsQuestionWhat is the association of aspirin use with cardiovascular events and bleeding events in individuals without cardiovascular disease? FindingsIn this meta-analysis of 13 trials with 164 225 participants without cardiovascular disease, aspirin use was associated with a lower risk of cardiovascular events, defined as cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke (hazard ratio [HR], 0.89; absolute risk reduction, 0.38%) and an increased risk of major bleeding (HR, 1.43; absolute risk increase, 0.47%). MeaningIn individuals without cardiovascular disease, the use of aspirin was associated with a lower risk of cardiovascular events and an increased risk of major bleeding.
JAMA – American Medical Association
Published: Jan 22, 2019
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