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Association of Aspirin Use for Primary Prevention With Cardiovascular Events and Bleeding Events

Association of Aspirin Use for Primary Prevention With Cardiovascular Events and Bleeding Events Key PointsQuestionWhat is the association of aspirin use with cardiovascular events and bleeding events in individuals without cardiovascular disease? FindingsIn this meta-analysis of 13 trials with 164 225 participants without cardiovascular disease, aspirin use was associated with a lower risk of cardiovascular events, defined as cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke (hazard ratio [HR], 0.89; absolute risk reduction, 0.38%) and an increased risk of major bleeding (HR, 1.43; absolute risk increase, 0.47%). MeaningIn individuals without cardiovascular disease, the use of aspirin was associated with a lower risk of cardiovascular events and an increased risk of major bleeding. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Association of Aspirin Use for Primary Prevention With Cardiovascular Events and Bleeding Events

JAMA , Volume 321 (3) – Jan 22, 2019

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Publisher
American Medical Association
Copyright
Copyright 2019 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2018.20578
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionWhat is the association of aspirin use with cardiovascular events and bleeding events in individuals without cardiovascular disease? FindingsIn this meta-analysis of 13 trials with 164 225 participants without cardiovascular disease, aspirin use was associated with a lower risk of cardiovascular events, defined as cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke (hazard ratio [HR], 0.89; absolute risk reduction, 0.38%) and an increased risk of major bleeding (HR, 1.43; absolute risk increase, 0.47%). MeaningIn individuals without cardiovascular disease, the use of aspirin was associated with a lower risk of cardiovascular events and an increased risk of major bleeding.

Journal

JAMAAmerican Medical Association

Published: Jan 22, 2019

References

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