Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/american-medical-association/association-of-anticholinergic-drug-use-with-risk-for-late-age-related-89KsU0MsMc
References (58)
-
M. Swanson, G. McGwin (2008)
Anti-Inflammatory Drug Use and Age-Related Macular DegenerationOptometry and Vision Science, 85
-
S. Mebarki, C. Trivalle (2012)
Échelles d'évaluation de l'effet anticholinergique des médicaments.NPG Neurologie - Psychiatrie - Gériatrie, 12
-
Bastiaans (2013)
Factor Xa and thrombin stimulate proinflammatory and profibrotic mediator production by retinal pigment epithelial cells: a role in vitreoretinal disorders?Graefes Arch Clin Exp Ophthalmol, 251
-
N. Lechevallier-Michel, M. Molimard, J. Dartigues, C. Fabrigoule, A. Fourrier-Réglat (2005)
Drugs with anticholinergic properties and cognitive performance in the elderly: results from the PAQUID Study.British journal of clinical pharmacology, 59 2
-
R. Klein, Chelsea Myers, B. Klein (2014)
Vasodilators, blood pressure-lowering medications, and age-related macular degeneration: the Beaver Dam Eye Study.Ophthalmology, 121 8
-
A. Fisher, Z. Pittel, R. Haring, N. Bar-Ner, M. Kliger-Spatz, N. Natan, Inbal Egozi, H. Sonego, I. Marcovitch, R. Brandeis (2007)
M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer’s diseaseJournal of Molecular Neuroscience, 20
-
I. Carrière, A. Fourrier-Réglat, J. Dartigues, O. Rouaud, F. Pasquier, K. Ritchie, M. Ancelin (2009)
Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: the 3-city study.Archives of internal medicine, 169 14
-
T. Beach, P. Potter, Y. Kuo, M. Emmerling, R. Durham, S. Webster, D. Walker, L. Sue, Sarah Scott, K. Layne, A. Roher (2000)
Cholinergic deafferentation of the rabbit cortex: a new animal model of Aβ depositionNeuroscience Letters, 283
-
S. Woo, K. Park, Jeeyun Ahn, J. Choe, Hyeon Jeong, Ji Han, T. Kim, Ki Kim (2012)
Cognitive impairment in age-related macular degeneration and geographic atrophy.Ophthalmology, 119 10
-
Julien Bruban, A. Glotin, Virginie Dinet, Naima Chalour, F. Sennlaub, L. Jonet, Na An, A. Faussat, F. Mascarelli (2009)
Amyloid‐β(1‐42) alters structure and function of retinal pigmented epithelial cellsAging Cell, 8
-
R. Bourne, Gretchen Stevens, Richard White, Jennifer Smith, S. Flaxman, Holly Price, J. Jonas, J. Keeffe, J. Leasher, K. Naidoo, K. Pesudovs, S. Resnikoff, H. Taylor (2013)
Causes of vision loss worldwide, 1990-2010: a systematic analysis.The Lancet. Global health, 1 6
-
B. Gopinath, G. Liew, A. Kifley, P. Mitchell (2016)
Thyroid Dysfunction and Ten-Year Incidence of Age-Related Macular Degeneration.Investigative ophthalmology & visual science, 57 13
-
Jiying Wang, K. Ohno-Matsui, Takeshi Yoshida, A. Kojima, N. Shimada, K. Nakahama, Olga Safranova, N. Iwata, T. Saido, M. Mochizuki, I. Morita (2008)
Altered Function of Factor I Caused by Amyloid β: Implication for Pathogenesis of Age-Related Macular Degeneration from Drusen1The Journal of Immunology, 181
-
Erik Elm, Douglas Altman, Matthias Egger, Stuart Pocock, P. Gtzsche, Jan Vandenbroucke (2007)
The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational StudiesAnnals of Internal Medicine, 147
-
Fisher (2003)
M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer?s disease: implications in future therapy.J Mol Neurosci, 20
-
I. Ionov, Irina Pushinskaya (2010)
Amyloid-β production in aged guinea pigs: atropine-induced enhancement is reversed by naloxoneNeuroscience Letters, 480
-
L. Johnson, William Leitner, Alexander Rivest, Michelle Staples, M. Radeke, Don Anderson (2002)
The Alzheimer's Aβ-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degenerationProceedings of the National Academy of Sciences of the United States of America, 99
-
L. Lim, P. Mitchell, J. Seddon, F. Holz, T. Wong (2012)
Age-related macular degenerationThe Lancet, 379
-
T. Pham, A. Kifley, P. Mitchell, Jie-Jin Wang (2006)
Relation of Age-Related Macular Degeneration and Cognitive Impairment in an Older PopulationGerontology, 52
-
Mary Samuel (2015)
American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older AdultsJournal of the American Geriatrics Society, 63
-
R. Bourne, J. Jonas, S. Flaxman, J. Keeffe, J. Leasher, K. Naidoo, M. Parodi, K. Pesudovs, Holly Price, Richard White, T. Wong, S. Resnikoff, H. Taylor (2014)
Prevalence and causes of vision loss in high-income countries and in Eastern and Central Europe: 1990–2010British Journal of Ophthalmology, 98
-
R. Carnahan, B. Lund, P. Perry, B. Pollock, K. Culp (2006)
The Anticholinergic Drug Scale as a Measure of Drug‐Related Anticholinergic Burden: Associations With Serum Anticholinergic ActivityThe Journal of Clinical Pharmacology, 46
-
L. Ellett, N. Pratt, E. Ramsay, J. Barratt, E. Roughead (2014)
Multiple Anticholinergic Medication Use and Risk of Hospital Admission for Confusion or DementiaJournal of the American Geriatrics Society, 62
-
D. Walsh, L. Bresciani, D. Saunders, M. Manca, A. Jen, S. Gentleman, L. Jen (2005)
Amyloid beta peptide causes chronic glial cell activation and neuro‐degeneration after intravitreal injectionNeuropathology and Applied Neurobiology, 31
-
U. Chakravarthy, T. Wong, A. Fletcher, E. Piault, C. Evans, G. Zlateva, R. Buggage, A. Pleil, P. Mitchell (2010)
Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysisBMC Ophthalmology, 10
-
T. Dentchev, A. Milam, V. Lee, J. Trojanowski, J. Dunaief (2003)
Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas.Molecular vision, 9
-
Yuhai Zhao, S. Bhattacharjee, Brandon Jones, J. Hill, C. Clement, K. Sambamurti, P. Dua, W. Lukiw (2015)
Beta-Amyloid Precursor Protein (βAPP) Processing in Alzheimer’s Disease (AD) and Age-Related Macular Degeneration (AMD)Molecular Neurobiology, 52
-
Guo-yuan Sui, Guang-cong Liu, Guang-ying Liu, Yan-yan Gao, Yan Deng, Wen-Ying Wang, Shu-Hui Tong, Lie Wang (2012)
Is sunlight exposure a risk factor for age-related macular degeneration? A systematic review and meta-analysisBritish Journal of Ophthalmology, 97
-
C. Augood, J. Vingerling, P. Jong, U. Chakravarthy, J. Seland, G. Soubrane, L. Tomazzoli, F. Topouzis, G. Bentham, M. Rahu, J. Vioque, I. Young, A. Fletcher (2006)
Prevalence of age-related maculopathy in older Europeans: the European Eye Study (EUREYE).Archives of ophthalmology, 124 4
-
M. Boustani, N. Campbell, Stephanie Munger, I. Maidment, C. Fox (2008)
Impact of anticholinergics on the aging brain: a review and practical applicationAging Health, 4
-
Jie-Jin Wang, P. Mitchell, Wayne Smith, M. Gillies, F. Billson (2003)
Systemic use of anti-inflammatory medications and age-related maculopathy: the Blue Mountains Eye StudyOphthalmic Epidemiology, 10
-
I-Hung Shao, Chen-pang Hou, shao-Ming chen, Chien-Lun Chen, Yu-Hsiang Lin, P. Chang, K. Tsui (2020)
Clinical Interventions in Aging -
M. Laroche, J. Charmes, L. Merle (2007)
Potentially inappropriate medications in the elderly: a French consensus panel listEuropean Journal of Clinical Pharmacology, 63
-
R. Leeuwen, S. Tomany, Jie-Jin Wang, R. Klein, P. Mitchell, A. Hofman, B. Klein, J. Vingerling, R. Cumming, P. Jong (2004)
Is medication use associated with the incidence of early age-related maculopathy? Pooled findings from 3 continents.Ophthalmology, 111 6
-
J. Ness, A. Hoth, M. Barnett, R. Shorr, P. Kaboli (2006)
Anticholinergic medications in community-dwelling older veterans: prevalence of anticholinergic symptoms, symptom burden, and adverse drug events.The American journal of geriatric pharmacotherapy, 4 1
-
Johnson (2002)
The Alzheimer?s A beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration.Proc Natl Acad Sci U S A, 99
-
F. Montastruc, E. Retailleau, V. Rousseau, H. Bagheri, J. Montastruc (2014)
Atropinic burden of prescription forms in France: a study in community pharmacies in 2013European Journal of Clinical Pharmacology, 70
-
C. Fox, K. Richardson, I. Maidment, G. Savva, F. Matthews, D. Smithard, S. Coulton, C. Katona, M. Boustani, C. Brayne (2011)
Anticholinergic Medication Use and Cognitive Impairment in the Older Population: The Medical Research Council Cognitive Function and Ageing StudyJournal of the American Geriatrics Society, 59
-
Liang Li, W. Li, Changzheng Chen, Zuohuizi Yi, Yun-yun Zhou (2015)
Is aspirin use associated with age‐related macular degeneration? A meta‐analysisJournal of Clinical Pharmacy and Therapeutics, 40
-
D. Tsai, Shih-Jen Chen, Chin-Chou Huang, M. Yuan, H. Leu (2015)
Age-Related Macular Degeneration and Risk of Degenerative Dementia among the Elderly in Taiwan: A Population-Based Cohort Study.Ophthalmology, 122 11
-
Zhou (2016)
Lower cognitive function in patients with age-related macular degeneration: a meta-analysis.Clin Interv Aging, 11
-
C. Delcourt, I. Carrière, A. Ponton-Sanchez, Sylvie Fourrey, A. Lacroux, L. Papoz (2001)
Light exposure and the risk of age-related macular degeneration: the Pathologies Oculaires Liées à l'Age (POLA) study.Archives of ophthalmology, 119 10
-
J. Bastiaans, J. Meurs, Conny Holten-Neelen, Marja Nijenhuis, Marion Kolijn-Couwenberg, P. Hagen, R. Kuijpers, H. Hooijkaas, W. Dik (2013)
Factor Xa and thrombin stimulate proinflammatory and profibrotic mediator production by retinal pigment epithelial cells: a role in vitreoretinal disorders?Graefe's Archive for Clinical and Experimental Ophthalmology, 251
-
Jiying Wang, K. Ohno-Matsui, Takeshi Yoshida, N. Shimada, S. Ichinose, Tetsuji Sato, M. Mochizuki, I. Morita (2009)
Amyloid‐β up‐regulates complement factor B in retinal pigment epithelial cells through cytokines released from recruited macrophages/microglia: Another mechanism of complement activation in age‐related macular degenerationJournal of Cellular Physiology, 220
-
DonnaM. Fich, lamesW. Cooper, iamE. Wade, Fashp PhannD, JenniJer Waller, R. Maclean, Marh Beers (2003)
Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts.Archives of internal medicine, 163 22
-
Carlos Durán, M. Azermai, R. Stichele (2013)
Systematic review of anticholinergic risk scales in older adultsEuropean Journal of Clinical Pharmacology, 69
-
J. Rudolph, Marci Salow, Michael Angelini, R. McGlinchey (2008)
The anticholinergic risk scale and anticholinergic adverse effects in older persons.Archives of internal medicine, 168 5
-
P. Gehlbach, Tianjing Li, E. Hatef (2009)
Statins for age-related macular degeneration.The Cochrane database of systematic reviews, 3
-
J. Ambati, B. Fowler (2012)
Mechanisms of Age-Related Macular DegenerationNeuron, 75
-
L. Han, Joseph Agostini, H. Allore (2008)
Cumulative Anticholinergic Exposure Is Associated with Poor Memory and Executive Function in Older MenJournal of the American Geriatrics Society, 56
-
F. Moulis, G. Moulis, L. Balardy, S. Gérard, F. Montastruc, S. Sourdet, M. Rougé-Bugat, M. Lapeyre-Mestre, J. Montastruc, Y. Rolland, B. Vellas (2015)
Exposure to atropinic drugs and frailty status.Journal of the American Medical Directors Association, 16 3
-
C. Delcourt, A. Cougnard-Grégoire, M. Boniol, I. Carrière, J. Doré, M. Delyfer, M. Rougier, M. Goff, J. Dartigues, P. Barberger‐Gateau, J. Korobelnik (2014)
Lifetime exposure to ambient ultraviolet radiation and the risk for cataract extraction and age-related macular degeneration: the Alienor Study.Investigative ophthalmology & visual science, 55 11
-
A. Roher, Y. Kuo, P. Potter, M. Emmerling, R. Durham, D. Walker, L. Sue, W. Honer, T. Beach (2000)
Cortical Cholinergic Denervation Elicits Vascular Aβ DepositionAnnals of the New York Academy of Sciences, 903
-
Gray (2015)
Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study.JAMA Intern Med, 175
-
Don Anderson, K. Talaga, Alexander Rivest, E. Barrón, G. Hageman, L. Johnson (2004)
Characterization of β amyloid assemblies in drusen: The deposits associated with aging and age-related macular degenerationExperimental Eye Research, 78
-
M. Ancelin, S. Artero, F. Portet, A. Dupuy, J. Touchon, K. Ritchie (2006)
Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort studyBMJ : British Medical Journal, 332
-
S. Gray, Melissa Anderson, S. Dublin, J. Hanlon, R. Hubbard, Rod Walker, Onchee Yu, P. Crane, E. Larson (2015)
Cumulative Use of Strong Anticholinergic Medications and Incident Dementia -
R. Liu, Jiangyuan Gao, Sijia Cao, N. Sandhu, J. Cui, Chai Chou, Edward Fang, J. Matsubara (2013)
Inflammatory mediators induced by amyloid-beta in the retina and RPE in vivo: implications for inflammasome activation in age-related macular degeneration.Investigative ophthalmology & visual science, 54 3
- Publisher
- American Medical Association
- Copyright
- Copyright 2018 American Medical Association. All Rights Reserved.
- ISSN
- 2168-6165
- eISSN
- 2168-6173
- DOI
- 10.1001/jamaophthalmol.2018.1719
- Publisher site
- See Article on Publisher Site
Abstract
Key PointsQuestionIs anticholinergic drug use associated with late age-related macular degeneration? FindingsIn this case-control study, at least 3 months’ use of anticholinergic drugs was associated with increased risk of AMD. This association was greater with prolonged use and high Anticholinergic Burden Score. MeaningWhile confounders that were not addressed could have contributed or accounted entirely for the results, these findings suggest the risk of late AMD may be increased with at least 3 months’ use of anticholinergic drugs, with a dose-effect association.
Journal
JAMA Ophthalmology – American Medical Association
Published: Jul 24, 2018