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Association Between Transcatheter Aortic Valve Replacement for Bicuspid vs Tricuspid Aortic Stenosis and Mortality or Stroke Among Patients at Low Surgical Risk

Association Between Transcatheter Aortic Valve Replacement for Bicuspid vs Tricuspid Aortic... Key PointsQuestionAre there differences in mortality and stroke between patients at low surgical risk who undergo transcatheter aortic valve replacement (TAVR) for bicuspid compared with tricuspid aortic stenosis? FindingsIn this registry-based cohort study that included 3168 propensity-matched pairs of patients at low surgical risk undergoing TAVR for bicuspid vs tricuspid aortic stenosis, there was no significant difference in death at 30 days (0.9% vs 0.8%), death at 1 year (4.6% vs 6.6%), stroke at 30 days (1.4% vs 1.2%), or stroke at 1 year (2.0% vs 2.1%). MeaningPatients at low surgical risk who underwent TAVR for bicuspid aortic stenosis compared with tricuspid aortic stenosis had no significant difference in mortality or stroke at 30 days or 1 year. Because of the potential for selection bias, randomized trials would be needed to adequately assess the efficacy and safety of TAVR for bicuspid aortic stenosis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Association Between Transcatheter Aortic Valve Replacement for Bicuspid vs Tricuspid Aortic Stenosis and Mortality or Stroke Among Patients at Low Surgical Risk

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Publisher
American Medical Association
Copyright
Copyright 2021 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2021.13346
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionAre there differences in mortality and stroke between patients at low surgical risk who undergo transcatheter aortic valve replacement (TAVR) for bicuspid compared with tricuspid aortic stenosis? FindingsIn this registry-based cohort study that included 3168 propensity-matched pairs of patients at low surgical risk undergoing TAVR for bicuspid vs tricuspid aortic stenosis, there was no significant difference in death at 30 days (0.9% vs 0.8%), death at 1 year (4.6% vs 6.6%), stroke at 30 days (1.4% vs 1.2%), or stroke at 1 year (2.0% vs 2.1%). MeaningPatients at low surgical risk who underwent TAVR for bicuspid aortic stenosis compared with tricuspid aortic stenosis had no significant difference in mortality or stroke at 30 days or 1 year. Because of the potential for selection bias, randomized trials would be needed to adequately assess the efficacy and safety of TAVR for bicuspid aortic stenosis.

Journal

JAMAAmerican Medical Association

Published: Sep 21, 2021

References