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Adjustment Methods: Propensity Score Methods for Bias Reduction in the Comparison of a Treatment to a Non‐Randomized Control Group
- Publisher
- American Medical Association
- Copyright
- Copyright 2021 American Medical Association. All Rights Reserved.
- ISSN
- 0098-7484
- eISSN
- 1538-3598
- DOI
- 10.1001/jama.2021.13346
- Publisher site
- See Article on Publisher Site
Abstract
Key PointsQuestionAre there differences in mortality and stroke between patients at low surgical risk who undergo transcatheter aortic valve replacement (TAVR) for bicuspid compared with tricuspid aortic stenosis? FindingsIn this registry-based cohort study that included 3168 propensity-matched pairs of patients at low surgical risk undergoing TAVR for bicuspid vs tricuspid aortic stenosis, there was no significant difference in death at 30 days (0.9% vs 0.8%), death at 1 year (4.6% vs 6.6%), stroke at 30 days (1.4% vs 1.2%), or stroke at 1 year (2.0% vs 2.1%). MeaningPatients at low surgical risk who underwent TAVR for bicuspid aortic stenosis compared with tricuspid aortic stenosis had no significant difference in mortality or stroke at 30 days or 1 year. Because of the potential for selection bias, randomized trials would be needed to adequately assess the efficacy and safety of TAVR for bicuspid aortic stenosis.
Journal
JAMA – American Medical Association
Published: Sep 21, 2021