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Association Between Topical Calcineurin Inhibitor Use and Risk of Cancer, Including Lymphoma, Keratinocyte Carcinoma, and Melanoma

Association Between Topical Calcineurin Inhibitor Use and Risk of Cancer, Including Lymphoma,... Key PointsQuestionIs topical calcineurin inhibitor (TCI) use associated with an increased risk of cancer? FindingsThis systematic review and meta-analysis of 11 studies revealed no association between TCI use and risk of cancer overall or skin cancer. Lymphoma risk was elevated with TCI use. MeaningAlthough this study found a positive association between TCI use and lymphoma, the low absolute risk of lymphoma makes the potential increased risk attributable to TCI use for any individual patient very small. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

Association Between Topical Calcineurin Inhibitor Use and Risk of Cancer, Including Lymphoma, Keratinocyte Carcinoma, and Melanoma

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Publisher
American Medical Association
Copyright
Copyright 2021 American Medical Association. All Rights Reserved.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/jamadermatol.2021.0345
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionIs topical calcineurin inhibitor (TCI) use associated with an increased risk of cancer? FindingsThis systematic review and meta-analysis of 11 studies revealed no association between TCI use and risk of cancer overall or skin cancer. Lymphoma risk was elevated with TCI use. MeaningAlthough this study found a positive association between TCI use and lymphoma, the low absolute risk of lymphoma makes the potential increased risk attributable to TCI use for any individual patient very small.

Journal

JAMA DermatologyAmerican Medical Association

Published: May 31, 2021

References