Key PointsQuestionIs topical calcineurin inhibitor (TCI) use associated with an increased risk of cancer? FindingsThis systematic review and meta-analysis of 11 studies revealed no association between TCI use and risk of cancer overall or skin cancer. Lymphoma risk was elevated with TCI use. MeaningAlthough this study found a positive association between TCI use and lymphoma, the low absolute risk of lymphoma makes the potential increased risk attributable to TCI use for any individual patient very small.
JAMA Dermatology – American Medical Association
Published: May 31, 2021