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Association Between Proton Pump Inhibitor Use and Risk of Asthma in Children

Association Between Proton Pump Inhibitor Use and Risk of Asthma in Children Key PointsQuestionIs proton pump inhibitor (PPI) use associated with risk of asthma in children? FindingsThis propensity score–matched cohort study included 80 870 pairs of children who were and were not new users of PPIs. The incidence rate of asthma was 21.8 per 1000 person-years among those who initiated PPI use and 14.0 per 1000 person-years among those who did not; the hazard ratio increased by 57%. MeaningThese findings suggest that asthma is one of several potential adverse events that should be considered when prescribing PPIs to children. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Association Between Proton Pump Inhibitor Use and Risk of Asthma in Children

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Publisher
American Medical Association
Copyright
Copyright 2021 American Medical Association. All Rights Reserved.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/jamapediatrics.2020.5710
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionIs proton pump inhibitor (PPI) use associated with risk of asthma in children? FindingsThis propensity score–matched cohort study included 80 870 pairs of children who were and were not new users of PPIs. The incidence rate of asthma was 21.8 per 1000 person-years among those who initiated PPI use and 14.0 per 1000 person-years among those who did not; the hazard ratio increased by 57%. MeaningThese findings suggest that asthma is one of several potential adverse events that should be considered when prescribing PPIs to children.

Journal

JAMA PediatricsAmerican Medical Association

Published: Apr 8, 2021

References