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Association Between NEDD4L Variation and the Genetic Risk of Acute Appendicitis

Association Between NEDD4L Variation and the Genetic Risk of Acute Appendicitis Key PointsQuestionWhat genetic loci are associated with acute appendicitis (AA)? FindingsIn this genome-wide association study, a genetic locus at chromosome 18q was found to be associated with AA, located in the NEDD4L gene. NEDD4L was also among the top differentially expressed genes in appendiceal tissue between AA patients and controls. MeaningThis study suggests that NEDD4L variations are associated with the development of AA; these findings can improve understanding of the genetic predisposition to and pathogenesis of AA. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Surgery American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2021 American Medical Association. All Rights Reserved.
ISSN
2168-6254
eISSN
2168-6262
DOI
10.1001/jamasurg.2021.3303
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionWhat genetic loci are associated with acute appendicitis (AA)? FindingsIn this genome-wide association study, a genetic locus at chromosome 18q was found to be associated with AA, located in the NEDD4L gene. NEDD4L was also among the top differentially expressed genes in appendiceal tissue between AA patients and controls. MeaningThis study suggests that NEDD4L variations are associated with the development of AA; these findings can improve understanding of the genetic predisposition to and pathogenesis of AA.

Journal

JAMA SurgeryAmerican Medical Association

Published: Oct 28, 2021

References