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Association Between a Chloride-Liberal vs Chloride-Restrictive Intravenous Fluid Administration Strategy and Kidney Injury in Critically Ill Adults

Association Between a Chloride-Liberal vs Chloride-Restrictive Intravenous Fluid Administration... PRELIMINARY COMMUNICATION Association Between a Chloride-Liberal vs Chloride-Restrictive Intravenous Fluid Administration Strategy and Kidney Injury in Critically Ill Adults Nor’azim Mohd Yunos, MD Context Administration of traditional chloride-liberal intravenous fluids may precipi- Rinaldo Bellomo, MD, FCICM tate acute kidney injury (AKI). Colin Hegarty, BSc Objective To assess the association of a chloride-restrictive (vs chloride-liberal) in- travenous fluid strategy with AKI in critically ill patients. David Story, MD Design, Setting, and Patients Prospective, open-label, sequential period pilot study Lisa Ho, MClinPharm of 760 patients admitted consecutively to the intensive care unit (ICU) during the con- Michael Bailey, PhD trol period (February 18 to August 17, 2008) compared with 773 patients admitted consecutively during the intervention period (February 18 to August 17, 2009) at a HE ADMINISTRATION OF INTRA- university-affiliated hospital in Melbourne, Australia. venous chloride is ubiquitous 1,2 Interventions During the control period, patients received standard intravenous flu- in critical care medicine. In ids. After a 6-month phase-out period (August 18, 2008, to February 17, 2009), any Taddition, many of the fluids use of chloride-rich intravenous fluids (0.9% saline, 4% succinylated gelatin solution, used for hydration and resuscitation or 4% albumin solution) was restricted to attending specialist approval only during http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Association Between a Chloride-Liberal vs Chloride-Restrictive Intravenous Fluid Administration Strategy and Kidney Injury in Critically Ill Adults

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Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2012.13356
pmid
23073953
Publisher site
See Article on Publisher Site

Abstract

PRELIMINARY COMMUNICATION Association Between a Chloride-Liberal vs Chloride-Restrictive Intravenous Fluid Administration Strategy and Kidney Injury in Critically Ill Adults Nor’azim Mohd Yunos, MD Context Administration of traditional chloride-liberal intravenous fluids may precipi- Rinaldo Bellomo, MD, FCICM tate acute kidney injury (AKI). Colin Hegarty, BSc Objective To assess the association of a chloride-restrictive (vs chloride-liberal) in- travenous fluid strategy with AKI in critically ill patients. David Story, MD Design, Setting, and Patients Prospective, open-label, sequential period pilot study Lisa Ho, MClinPharm of 760 patients admitted consecutively to the intensive care unit (ICU) during the con- Michael Bailey, PhD trol period (February 18 to August 17, 2008) compared with 773 patients admitted consecutively during the intervention period (February 18 to August 17, 2009) at a HE ADMINISTRATION OF INTRA- university-affiliated hospital in Melbourne, Australia. venous chloride is ubiquitous 1,2 Interventions During the control period, patients received standard intravenous flu- in critical care medicine. In ids. After a 6-month phase-out period (August 18, 2008, to February 17, 2009), any Taddition, many of the fluids use of chloride-rich intravenous fluids (0.9% saline, 4% succinylated gelatin solution, used for hydration and resuscitation or 4% albumin solution) was restricted to attending specialist approval only during

Journal

JAMAAmerican Medical Association

Published: Oct 17, 2012

References