CLINICAL REVIEW CLINICIAN’S CORNER Association Between 9p21 Genomic Markers and Heart Disease A Meta-analysis Glenn E. Palomaki, BS Context Associations between chromosome 9p21 single-nucleotide polymorphisms Stephanie Melillo, MPH (SNPs) and heart disease have been reported and replicated. If testing improves risk as- sessments using traditional factors, it may provide opportunities to improve public health. Linda A. Bradley, PhD Objectives To perform a targeted systematic review of published literature for effect REVENTING AND MANAGING CAR- size, heterogeneity, publication bias, and strength of evidence and to consider whether diovascular disease (CVD) pre- testing might provide clinical utility. sents a challenge for health care Data Sources Electronic search via HuGE Navigator through January 2009 and re- 1,2 Pand public health. Nonmodi- view of reference lists from included articles. fiable risk factors include increasing age, Study Selection English-language articles that tested for 9p21 SNPs with coronary male sex, and heredity. Modifiable risk heart/artery disease or myocardial infarction as primary outcomes. Included articles factors include smoking, hypertension, also provided race, numbers of participants, and data to compute an odds ratio (OR). dyslipidemia, obesity, physical inactiv- Articles were excluded if reporting only intermediate outcomes (eg, atherosclerosis) 3-5 ity, and diabetes. Among men, the an- or
JAMA – American Medical Association
Published: Feb 17, 2010
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