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Assessment of Blinding in a Tinnitus Treatment Trial—Reply

Assessment of Blinding in a Tinnitus Treatment Trial—Reply Letters toring of the HA injection amount and injection site by laryn- authors claim that these data demonstrate that blinding was goscopy will become less important. Regarding airway pat- maintained because the patients in each subgroup guessed with ency, we have mentioned that surgeons need to confirm that the 50% accuracy of a coin flip. the contralateral healthy vocal fold can fully abduct before any However, that subgroup analysis is misleading. Instead, vocal fold medialization procedure. With this precaution, over- look at the 32 patients treated with placebo, 66% of whom injection of fat under general anesthesia is commonly per- (21 of 32) correctly guessed placebo, thus exposing a 16% formed without airway problem. Furthermore, we do not deviation from 50% coin-flip accuracy seen with perfect recommend bilateral injection with our technique. blinding. The 32 patients treated with active rTMS guessed Finally, Tang and coauthors comment that our technique correctly at a rate of 34% (11 of 32), not the 50% coin-flip will take away the surgeon’s ability to judge vertical height, the rate expected with perfect blinding. The authors attribute amount of medialization, and the quality of the glottal wave. this deviation to the smallness of the therapeutic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Otolaryngology - Head & Neck Surgery American Medical Association

Assessment of Blinding in a Tinnitus Treatment Trial—Reply

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Publisher
American Medical Association
Copyright
Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6181
eISSN
2168-619X
DOI
10.1001/jamaoto.2015.2422
pmid
26583514
Publisher site
See Article on Publisher Site

Abstract

Letters toring of the HA injection amount and injection site by laryn- authors claim that these data demonstrate that blinding was goscopy will become less important. Regarding airway pat- maintained because the patients in each subgroup guessed with ency, we have mentioned that surgeons need to confirm that the 50% accuracy of a coin flip. the contralateral healthy vocal fold can fully abduct before any However, that subgroup analysis is misleading. Instead, vocal fold medialization procedure. With this precaution, over- look at the 32 patients treated with placebo, 66% of whom injection of fat under general anesthesia is commonly per- (21 of 32) correctly guessed placebo, thus exposing a 16% formed without airway problem. Furthermore, we do not deviation from 50% coin-flip accuracy seen with perfect recommend bilateral injection with our technique. blinding. The 32 patients treated with active rTMS guessed Finally, Tang and coauthors comment that our technique correctly at a rate of 34% (11 of 32), not the 50% coin-flip will take away the surgeon’s ability to judge vertical height, the rate expected with perfect blinding. The authors attribute amount of medialization, and the quality of the glottal wave. this deviation to the smallness of the therapeutic

Journal

JAMA Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: Nov 1, 2015

References