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Slamon (2001)
783N Engl J Med, 344
- Publisher
- American Medical Association
- Copyright
- Copyright 2021 American Medical Association. All Rights Reserved.
- ISSN
- 2374-2437
- eISSN
- 2374-2445
- DOI
- 10.1001/jamaoncol.2021.1600
- Publisher site
- See Article on Publisher Site
Abstract
Key PointsQuestionWhat is the association of targeted therapy with survival for patients with intracranial metastatic disease (IMD)? FindingsIn this cohort study of 26 676 patients with IMD, prolonged survival was observed in patients with IMD and ERBB2 (formerly HER2)–positive breast cancer, EGFR-positive lung and bronchus cancer, or BRAF-positive melanoma who received targeted therapy compared with those who did not. In patients with metastatic ERBB2-positive breast cancer or EGFR-positive lung and bronchus cancer, but not BRAF-positive melanoma, shorter survival was observed in patients with IMD vs those without. MeaningTargeted therapies seem to be associated with improved survival in patients with IMD and ERBB2-positive breast cancer, EGFR-positive lung and bronchus cancer, or BRAF-positive melanoma.
Journal
JAMA Oncology – American Medical Association
Published: Aug 3, 2021