OPHTHALMIC MOLECULAR GENETICS Assessing Susceptibility to Age-Related Macular Degeneration With Genetic Markers and Environmental Factors Yuhong Chen, MD, PhD; Jiexi Zeng, MD; Chao Zhao, BS; Kevin Wang, BS; Elizabeth Trood, MD; Jeanette Buehler, BS; Matthew Weed, MD; Daniel Kasuga, MD; Paul S. Bernstein, MD, PhD; Guy Hughes, BS; Victoria Fu, BS; Jessica Chin, MS; Clara Lee, BS; Maureen Crocker, MBA; Matthew Bedell, MD; Francesca Salasar, MD; Zhenglin Yang, MD; Michael Goldbaum, MD; Henry Ferreyra, MD; William R. Freeman, MD; Igor Kozak, MD, PhD; Kang Zhang, MD, PhD Objectives: To evaluate the independent and joint ef- HTRA1/LOC387715 rs10490924 TT, and 2.66 (1.43- fects of genetic factors and environmental variables on 4.96) for C3 rs2230199 GG. Smoking was independently advanced forms of age-related macular degeneration associated with advanced AMD after controlling for age, (AMD), including geographic atrophy and choroidal neo- sex, body mass index, and all genetic variants. vascularization, and to develop a predictive model with genetic and environmental factors included. Conclusion: CFH confers more risk to the bilaterality of geographic atrophy, whereas HTRA1/LOC387715 con- Methods: Demographic information, including age at tributes more to the bilaterality of choroidal neovascu- onset, smoking status, and body mass index, was col- larization. C3 confers
JAMA Ophthalmology – American Medical Association
Published: Mar 1, 2011
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