ORIGINAL CONTRIBUTION CLINICIAN’S CORNER Aspirin for Prevention of Cardiovascular Events in a General Population Screened for a Low Ankle Brachial Index A Randomized Controlled Trial F. Gerald R. Fowkes, FRCPE Context A low ankle brachial index (ABI) indicates atherosclerosis and an increased Jacqueline F. Price, MD risk of cardiovascular and cerebrovascular events. Screening for a low ABI can identify an asymptomatic higher risk group potentially amenable to preventive treatments. Marlene C. W. Stewart, PhD Objective To determine the effectiveness of aspirin in preventing events in people Isabella Butcher, PhD with a low ABI identified on screening the general population. Gillian C. Leng, MD Design, Setting, and Participants The Aspirin for Asymptomatic Atherosclerosis Alistair C. H. Pell, MD trial was an intention-to-treat double-blind randomized controlled trial conducted from April 1998 to October 2008, involving 28 980 men and women aged 50 to 75 years Peter A. G. Sandercock, DM living in central Scotland, free of clinical cardiovascular disease, recruited from a com- Keith A. A. Fox, FRCP munity health registry, and had an ABI screening test. Of those, 3350 with a low ABI Gordon D. O. Lowe, DSc (0.95) were entered into the trial, which was powered to detect a
JAMA – American Medical Association
Published: Mar 3, 2010
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