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Aspirin and NSAID Chemoprevention, Gene-Environment Interactions, and Risk of Colorectal Cancer

Aspirin and NSAID Chemoprevention, Gene-Environment Interactions, and Risk of Colorectal Cancer Opinion Editorials represent the opinions of the authors and JAMA EDITORIAL and not those of the American Medical Association. Aspirin and NSAID Chemoprevention, Gene-Environment Interactions, and Risk of Colorectal Cancer Richard C. Wender, MD In this issue of JAMA, Nan and colleagues report the results 0.70]). This genotype was found in 96% of the population, of a gene-environment interaction study examining an inter- so it is not surprising that the population-wide protective action between a genetic polymorphism and the regular use of effect of aspirin is roughly similar to the effect in the protec- aspirin or other nonsteroidal tive genotype. Significant complexity in clinical decisions anti-inflammatory agents emerges from considering the 4% of the population who (NSAIDs) and the association have a different genotype, TA or AA. Among these individu- Related article joi150026 with risk of colorectal cancer. als, not only was no protective association found, but use of This case-control study is scientifically noteworthy for 4 dis- aspirin, NSAIDs, or both was associated with an increased tinct reasons. First, the study advances understanding of how risk of colon cancer (OR, 1.89 [95% CI, 1.27-2.81]). to conduct research designed to detect gene-environment in- This study illustrates many aspects of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Aspirin and NSAID Chemoprevention, Gene-Environment Interactions, and Risk of Colorectal Cancer

JAMA , Volume 313 (11) – Mar 17, 2015

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Publisher
American Medical Association
Copyright
Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2015.1032
pmid
25781439
Publisher site
See Article on Publisher Site

Abstract

Opinion Editorials represent the opinions of the authors and JAMA EDITORIAL and not those of the American Medical Association. Aspirin and NSAID Chemoprevention, Gene-Environment Interactions, and Risk of Colorectal Cancer Richard C. Wender, MD In this issue of JAMA, Nan and colleagues report the results 0.70]). This genotype was found in 96% of the population, of a gene-environment interaction study examining an inter- so it is not surprising that the population-wide protective action between a genetic polymorphism and the regular use of effect of aspirin is roughly similar to the effect in the protec- aspirin or other nonsteroidal tive genotype. Significant complexity in clinical decisions anti-inflammatory agents emerges from considering the 4% of the population who (NSAIDs) and the association have a different genotype, TA or AA. Among these individu- Related article joi150026 with risk of colorectal cancer. als, not only was no protective association found, but use of This case-control study is scientifically noteworthy for 4 dis- aspirin, NSAIDs, or both was associated with an increased tinct reasons. First, the study advances understanding of how risk of colon cancer (OR, 1.89 [95% CI, 1.27-2.81]). to conduct research designed to detect gene-environment in- This study illustrates many aspects of

Journal

JAMAAmerican Medical Association

Published: Mar 17, 2015

References