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Aspirin and Dipyridamole Inhibit Endothelial Healing

Aspirin and Dipyridamole Inhibit Endothelial Healing Abstract • Aspirin and dipyridamole have been used to treat the thromboembolic complications of atherosclerosis. We studied the effects of these drugs on the rate of endothelial healing after a standard de-endothelializing injury of the thoracic aorta. Twenty-five rabbits received 13.5 mg/kg/day of aspirin and 15 mg/kg/day of dipyridamole one week before injury and for the period of endothelial regrowth. There were 25 control animals. Mean serum aspirin salicylate levels were 12 μg/dL at the time of injury and 15 μg/dL at death. Areas of endothelial regrowth were measured by Evans blue dye at 1, 4, 7, and 14 days after injury. The percentage of endothelial regrowth was measured by computor-assisted morphometry. Antiplatelet treatment retarded endothelial regrowth by 66% at four days, 22% at seven days, and 28% at 14 days. Antiplatelet drugs must be used cautiously, as re-endothelialization of injured arteries Is retarded. (Arch Surg 1982;117:1459-1464) References 1. Mustard JF, Packham MA, Kinlough-Rathbone RL: Non-steroidal anti-inflammatory agents and coronary artery disease. Acta Med Scand Suppl 1980;642:180-190. 2. Oblath RW, Buckley FO, Green RM, et al: Prevention of anastomotic neointimal fibrous hyperplasia in femoral artery bypass grafts by aspirin and dipyridamole. Surgery 1978;84:37-44. 3. Metke MP, Lie JT, Fuster V, et al: Reduction of intimal thickening in canine coronary artery bypass vein grafts with dipyridamole and aspirin. Am J Cardiol 1979;43:1144-1148.Crossref 4. DePalma RG, Bellon EM, Manalo P: Failure of antiplatelet agents to control dietary atherosclerosis, abstracted. J Cardiovasc Surg 1981;22:445. 5. Manalo P, DePalma RG, Bellon EM: Effect of antiplatelet agents on morphology of dietarily induced atherosclerosis in rhesus monkeys. J Clin Pathol, in press. 6. Carson SW, Demling RH, Esquivel CO: Aspirin failure in symptomatic atherosclerotic carotid artery disease. Surgery 1981;90:1084-1092. 7. Chidi CC, DePalma RG: Atherogenic potential of the embolectomy catheter. Surgery 1978;83:549-557. 8. Clark JM, Glagov S: Evaluation and publication of scanning electron micrographs. Science 1976;192:1360-1361.Crossref 9. Canadian Cooperative Study Group: A randomized trial of aspirin and sulfinpyrazone in threatened stroke. N Engl J Med 1978;299:53-59.Crossref 10. Hollander W, Kirkpatrick B, Paddock J, et al: Studies on the progression and regression of coronary and peripheral atherosclerosis in the cynomolgus monkey: I. Effect of dipyridamole and aspirin. Exp Mol Pathol 1979;30:55-73.Crossref 11. Pick R, Chediak J, Click G: Aspirin inhibits the development of coronary atherosclerosis in cynomolgus monkeys fed an atherogenic diet. J Clin Invest 1979;63:158-162.Crossref 12. August D, Tilson D: Modification of the myointimal response to arterial injury. Surg Forum 1980;30:337-338. 13. Clowes AW, Karnovsky MJ: Failure of certain antiplatelet drugs to affect myointimal thickening following arterial injury. Lab Invest 1977;36: 452-458. 14. Minick CR, Stemerman MB, Insull JW: Role of endothelium and hypercholesterolemia on intimal thickening and lipid accumulation. Am J Pathol 1979;95:131-157. 15. Bondjers G, Bjorkerud S: Arterial repair and atherosclerosis after mechanical injury. Atherosclerosis 1973;17:85-94.Crossref 16. Chidi CC, Klein L, DePalma RG: Effect of regenerated endothelium on collagen content in the injured artery. Surg Gynecol Obstet 1979;148: 839-843. 17. Wu K, Chenk YC, Fordham E, et al: Differential effects of two doses of aspirin on platelet vessel wall interaction in vivo. J Clin Invest 1981;68: 382-387.Crossref 18. Harjola PT, Meurala H, Frick MH: Prevention of early reocclusion by dipyridamole and ASA in arterial reconstructive surgery. J Cardiovasc Surg 1981;22:141-144. 19. Clopath P: The effect of acetylsalacylic acid (ASA) on the development of atherosclerotic lesion in miniature swine. Br J Exp Pathol 1980;61: 440-443. 20. Hauss W, Mey J, Schulte H: Effect of risk factors and antirheumatic drugs on the proliferation of aortic wall cells. Atherosclerosis 1979;34: 119-143.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Aspirin and Dipyridamole Inhibit Endothelial Healing

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References (23)

Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1982.01380350057008
Publisher site
See Article on Publisher Site

Abstract

Abstract • Aspirin and dipyridamole have been used to treat the thromboembolic complications of atherosclerosis. We studied the effects of these drugs on the rate of endothelial healing after a standard de-endothelializing injury of the thoracic aorta. Twenty-five rabbits received 13.5 mg/kg/day of aspirin and 15 mg/kg/day of dipyridamole one week before injury and for the period of endothelial regrowth. There were 25 control animals. Mean serum aspirin salicylate levels were 12 μg/dL at the time of injury and 15 μg/dL at death. Areas of endothelial regrowth were measured by Evans blue dye at 1, 4, 7, and 14 days after injury. The percentage of endothelial regrowth was measured by computor-assisted morphometry. Antiplatelet treatment retarded endothelial regrowth by 66% at four days, 22% at seven days, and 28% at 14 days. Antiplatelet drugs must be used cautiously, as re-endothelialization of injured arteries Is retarded. (Arch Surg 1982;117:1459-1464) References 1. Mustard JF, Packham MA, Kinlough-Rathbone RL: Non-steroidal anti-inflammatory agents and coronary artery disease. Acta Med Scand Suppl 1980;642:180-190. 2. Oblath RW, Buckley FO, Green RM, et al: Prevention of anastomotic neointimal fibrous hyperplasia in femoral artery bypass grafts by aspirin and dipyridamole. Surgery 1978;84:37-44. 3. Metke MP, Lie JT, Fuster V, et al: Reduction of intimal thickening in canine coronary artery bypass vein grafts with dipyridamole and aspirin. Am J Cardiol 1979;43:1144-1148.Crossref 4. DePalma RG, Bellon EM, Manalo P: Failure of antiplatelet agents to control dietary atherosclerosis, abstracted. J Cardiovasc Surg 1981;22:445. 5. Manalo P, DePalma RG, Bellon EM: Effect of antiplatelet agents on morphology of dietarily induced atherosclerosis in rhesus monkeys. J Clin Pathol, in press. 6. Carson SW, Demling RH, Esquivel CO: Aspirin failure in symptomatic atherosclerotic carotid artery disease. Surgery 1981;90:1084-1092. 7. Chidi CC, DePalma RG: Atherogenic potential of the embolectomy catheter. Surgery 1978;83:549-557. 8. Clark JM, Glagov S: Evaluation and publication of scanning electron micrographs. Science 1976;192:1360-1361.Crossref 9. Canadian Cooperative Study Group: A randomized trial of aspirin and sulfinpyrazone in threatened stroke. N Engl J Med 1978;299:53-59.Crossref 10. Hollander W, Kirkpatrick B, Paddock J, et al: Studies on the progression and regression of coronary and peripheral atherosclerosis in the cynomolgus monkey: I. Effect of dipyridamole and aspirin. Exp Mol Pathol 1979;30:55-73.Crossref 11. Pick R, Chediak J, Click G: Aspirin inhibits the development of coronary atherosclerosis in cynomolgus monkeys fed an atherogenic diet. J Clin Invest 1979;63:158-162.Crossref 12. August D, Tilson D: Modification of the myointimal response to arterial injury. Surg Forum 1980;30:337-338. 13. Clowes AW, Karnovsky MJ: Failure of certain antiplatelet drugs to affect myointimal thickening following arterial injury. Lab Invest 1977;36: 452-458. 14. Minick CR, Stemerman MB, Insull JW: Role of endothelium and hypercholesterolemia on intimal thickening and lipid accumulation. Am J Pathol 1979;95:131-157. 15. Bondjers G, Bjorkerud S: Arterial repair and atherosclerosis after mechanical injury. Atherosclerosis 1973;17:85-94.Crossref 16. Chidi CC, Klein L, DePalma RG: Effect of regenerated endothelium on collagen content in the injured artery. Surg Gynecol Obstet 1979;148: 839-843. 17. Wu K, Chenk YC, Fordham E, et al: Differential effects of two doses of aspirin on platelet vessel wall interaction in vivo. J Clin Invest 1981;68: 382-387.Crossref 18. Harjola PT, Meurala H, Frick MH: Prevention of early reocclusion by dipyridamole and ASA in arterial reconstructive surgery. J Cardiovasc Surg 1981;22:141-144. 19. Clopath P: The effect of acetylsalacylic acid (ASA) on the development of atherosclerotic lesion in miniature swine. Br J Exp Pathol 1980;61: 440-443. 20. Hauss W, Mey J, Schulte H: Effect of risk factors and antirheumatic drugs on the proliferation of aortic wall cells. Atherosclerosis 1979;34: 119-143.Crossref

Journal

Archives of Surgery – American Medical Association

Published: Nov 1, 1982

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