Abstract • Aspergillosis of the cerebral ventricles developed in a 36-year-old heroin abuser who died during the sixth week of illness. The diagnosis was not made during life. A review of our case and of four previous cases from the literature indicates that aspergillosis should be considered in parenteral drug abusers with the syndrome of chronic meningitis or ventriculitis. The diagnosis is difficult to establish, but serologic tests may be helpful. This form of CNS aspergillosis can be cured with antifungal drugs. (Arch Intern Med 1983;143:161-164) References 1. Young RC, Bennett JE, Vogel CL, et al: Aspergillosis spectrum of the disease in 98 patients. Medicine 1970;49:147-173.Crossref 2. Meyer RD, Young LS, Armstrong D: Aspergillosis complicating neoplastic disease. Am J Med 1973;54:6-15.Crossref 3. Burston J, Blackwood W: A case of aspergillus infection of the brain. J Pathol Bacteriol 1963;86:225-229.Crossref 4. Gordon MA, Holzman RS, Senter H, et al: Aspergillus oryzae meningitis. JAMA 1976;235:2122-2123.Crossref 5. Kaufman DM, Thai LJ, Farmer PM: Central nervous system aspergillosis in two young adults. Neurology 1976;26:484-488.Crossref 6. Bryan CS, DiSalvo AF, Huffman LJ, et al: Communicating hydrocephalus caused by Aspergillus flavus. South Med J 1980;73:1641-1643.Crossref 7. Schaefer JC, Yu B, Armstrong D: Aspergillus immunodiffusion test in the early diagnosis of aspergillosis in adult leukemia patients. Am Rev Respir Dis 1976;113:325-329. 8. Tuazon CU, Hill R, Sheagren JL: Microbiologic study of street heroin and injection paraphernalia. J Infect Dis 1974;129:327-329.Crossref 9. Turner KJ, Papadimitrou J, Hackshaw R, et al: Experimental aspergillosis in normal rats infected intravenously. J Reticuloendothel Soc 1975;17:300-312.
Archives of Internal Medicine – American Medical Association
Published: Jan 1, 1983