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ARSPHENAMINE-RESISTANT SYPHILIS

ARSPHENAMINE-RESISTANT SYPHILIS Abstract The rapid disappearance of the spirochetes (Spirochaeta pallida) from the chancre and the relatively prompt healing of the cutaneous and mucosal manifestations of early syphilis following the administration of arsphenamine are some of the spectacular achievements of chemotherapy. Furthermore, the observations of the Cooperative Clinical Group 1 show that the adequate treatment of acute syphilis by the continuous and judicious use of modern antisyphilitic remedies produces a clinical and serologic cure in a large proportion of cases. With this advancement in the treatment of syphilis differences of opinion have arisen regarding the influence of modern antisyphilitic drugs on the course of the disease, and the medical literature is replete with articles in which the various phases of this complex problem are discussed. Some observers have argued that since the introduction of arsphenamine there has been an increase in the incidence of late visceral manifestations of syphilis and References 1. Stokes, J. H.; Cole, H. N.; Moore, J. E.; O'Leary, P. A.; Wile, U. J.; Parran, T., Jr.; Vonderlehr, R. A, and Usilton, L. J.: Standard Treatment Procedure in Early Syphilis , J. A. M. A. 102:1267-1272 ( (April 21) ) 1934.Crossref 2. Moore, J. E., and Robinson, H. M.: Question of Arsphenamine-Resistant Syphilis , Arch. Dermat. & Syph. 21:32-39 ( (Jan.) ) 1930. 3. Miller, Thomas H.: Problem of Arsphenamine-Resistant Syphilis: Report of a Case , J. A. M. A. 97:11-14 ( (July 4) ) 1931. 4. Moore, Joseph Earle: The Modern Treatment of Syphilis , Springfield, Ill., Charles C. Thomas, Publisher, 1933, pp. 38, 204 and 249. 5. Moore, J. E., and Kemp, J. E.: Treatment of Early Syphilis: Wassermann Reaction in Treated Early Syphilis , Bull. Johns Hopkins Hosp. 39:36-55 ( (July) ) 1926. 6. Wile, U. J.; Wieder, L., and Warthin, A. S.: Malignant Syphilis with New Explanation of Pathology of Cutaneous Lesions , Am. J. Syph. & Neurol. 14: 1-34 ( (Jan.) ) 1930. 7. Gadrat, J.: Syphilis maligne totalement anergique et mortelle , Ann. de dermat. et syph. 5:990-1008 ( (Nov.) ) 1934. 8. Milian, G.: Syphilis maligne précoce , Rev. franç. de dermat. et de vénéréol. 6:336-348 ( (June) ) 1930 9. Syphilis maligne précoce: Manifestations ulcéreuses ultérieures , Milian Rev. franç. de dermat. et de vénéréol. 6:266-268 ( (May) ) 1930. 10. Sylvestre, P.: Case of Early Malignant Syphilis , Rev. méd. de la Suisse Rom. 43:172-177 ( (March) ) 1923. 11. Lacapère and Decrop: Le syndrome malin dans la syphilis , Paris méd. 35:203-208, 1920. 12. The Reticulo-Endothelial System and Chemotherapy, editorial, J. Chemotherapy 8:120-124 ( (Jan.) ) 1932. 13. Kolmer, J. A., and Schamberg, J. F.: The Influence of Reticuloendothelial "Blockade" and Splenectomy upon Experimental Trypanosomiasis and Syphilis and the Chemotherapeutic Properties of Arsphenamine and Neoarsphenamine , Am. J. Syph. & Neurol. 17:176-187 ( (April) ) 1933. 14. Yorke, W.: Drug-Resistance , Brit. J. Ven. Dis. 9:83-109 ( (April) ) 1933. 15. Akatsu, S., and Noguchi, H.: The Drug-Fastness of Spirochetes to Arsenic, Mercurial and Iodide Compounds in Vitro , J. Exper. Med. 25:351-362, 1917. 16. Klauder, J. V.: Experimental Production of an Arsenic Resistant Strain of Spirochaeta Pallida in Rabbits , Arch. Dermat. & Syph. 9:446-458 ( (April) ) 1924. 17. Greenbaum, Sigmund S., and Rule, Anna M.: Resistant Syphilis, with Especial Reference to an Attempt to Produce Experimentally an Arsenic-Resistant Strain of Spirochaeta Pallida , Pennsylvania M. J. 39:339-343 ( (Feb.) ) 1936. 18. Hoffmann and Armuzzi, cited by Moore and Robinson.2 19. Nothaas, cited by Moore and Robinson.2 20. Beerman, Herman: Problem of Treatment-Resistant Syphilis, with Special Reference to Arsphenamine-Resistant Syphilis: Review of Literature and Experimental Study , Am. J. Syph., Gonor. & Ven. Dis. 20:296-334 ( (May) ) 1936. 21. Kloeppel, F. W.: Salvarsanresistenter Spirochätenstamm bei einem Ehepaar , München. med. Wchnschr. 73:1936-1937 ( (Nov.) ) 1926. 22. Nicolas, J.; Massia, G., and Lacassagne, J.: Sur la fréquence croissante des syphilis arséno-résistantes dans la région lyonnaise , Bull. Soc. franç. de dermat. et syph. 35:132-138 ( (Feb.) ) 1928. 23. Nicolas, J.; Lacassagne, J., and Froment, R.: Les syphilis novarsénorésistantes: Etude clinique et pathogénique; déductions pratiques , Presse méd. 38:513-516 ( (April 16) ) 1930. 24. Bonnet, L. M.: Sur la fréquence actuelle des syphilis arséno-résistantes , Lyon méd. 140:229-236 ( (Sept. 4) ) 1927. 25. Jessner, M.: Syphilis Refractory to Arsphenamine , Med. Klin. 19:857-859 ( (June 24) ) 1923. 26. Lutz, W.: Zur Kenntnis der gegen Salvarsan refraktären Syphilis , Schweiz. med. Wchnschr. 50:838-841 ( (Sept. 16) ) 1920. 27. Semon, H. C. G.: Clinical Case: Salvarsan-Resistant Syphilis , Brit. J. Ven. Dis. 6:323-326, 1930. 28. Lee, D. C.: Action of Arsphenamine and Mercury on the Treponema Pallidum , Am. J. Syph. 6:546-550 ( (July) ) 1922. 29. Moore,4 p. 68. 30. Kolmer, John A.: Principles and Practice of Chemotherapy, with Special Reference to the Specific and General Treatment of Syphilis , Philadelphia, W. B. Saunders Company, 1926, pp. 25-26. 31. Dale, H. H.: Chemotherapy , Physiol. Rev. 3:359-393 ( (July) ) 1923. 32. Gouin, J.; Bienvenue, A., and Ezel, J.: Nouveau cas de syphilis arsénorésistante prévue par la leucocyto-réaction , Bull. Soc. franç. de dermat. et syph. 41: 675-678 ( (April) ) 1934. 33. Stokes, John H.: Modern Clinical Syphilology, Philadelphia , W. B. Saunders Company, 1928, p. 24. 34. Wile, Udo J., and Shaw, J. W.: The Prenatal Treatment of Syphilis with Especial Reference to Early Syphilis in the Mother , J. A. M. A. 95:1791-1795 ( (Dec. 13) ) 1930.Crossref 35. Brown, W. H., and Pearce, Louise: Reaction of Pregnant and Lactating Females to Inoculation with Treponema Pallidum: A Preliminary Note , Am. J. Syph. 4:593 ( (Oct.) ) 1920. 36. Ingraham, Norman R., Jr., and Kahler, James E.: Diagnosis and Treatment of Syphilis Complicating Pregnancy , Am. J. Obst. & Gynec. 27:134-152 ( (Jan.) ) 1934. 37. Cole, H. N.; Moore, J. E.; O'Leary, P.; Stokes, J. H.; Wile, U. J.; Clark, T.; Parran, T.; Vonderlehr, R. A., and Usilton, L. J.: Cooperative Clinical Studies in the Treatment of Syphilis: Syphilis in Pregnancy , J. A. M. A. 106:464-467 ( (Feb. 8) ) 1936. 38. Halloran, C. R.: Syphilis and Pregnancy: Effect, Diagnosis, Treatment and Complications with Report of Unusual Nitritoid Crisis , Am. J. Syph. & Neurol. 14:222-230 ( (April) ) 1930. 39. Foerster, O. H.; McIntosh, R. L.; Wieder, L. M.; Foerster, H. R., and Cooper, G. A.: Mapharsen in the Treatment of Syphilis: A Preliminary Report , Arch. Dermat. & Syph. 32:868-889 ( (Dec.) ) 1935. 40. Dennie, C. C., and McBride, W. L.: Treatment of Resistant Somatic Syphilis , Arch. Dermat. & Syph. 30:1-5 ( (July) ) 1934. 41. Dennie, C. C.: Method of Increasing Specific Resistance of Syphilitic Individual to His Disease , South. M. J. 25:462-467 ( (May) ) 1932. 42. Hench, P. S.; Slocumb, C. H., and Popp, W. C.: Fever Therapy: Results for Gonorrheal Arthritis, Chronic Infectious (Atrophic) Arthritis and Other Forms of "Rheumatism," J. A. M. A. 104:1779-1790 ( (May 18) ) 1935. 43. Dennie, C. C.; Polsky, M., and Lemoine, A. N.: Hyperpyrexia Produced by the Hot Bath in the Treatment of Syphilis , J. Missouri M. A. 33:1-12 ( (Jan.) ) 1936. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

ARSPHENAMINE-RESISTANT SYPHILIS

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Publisher
American Medical Association
Copyright
Copyright © 1937 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1937.01470220047005
Publisher site
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Abstract

Abstract The rapid disappearance of the spirochetes (Spirochaeta pallida) from the chancre and the relatively prompt healing of the cutaneous and mucosal manifestations of early syphilis following the administration of arsphenamine are some of the spectacular achievements of chemotherapy. Furthermore, the observations of the Cooperative Clinical Group 1 show that the adequate treatment of acute syphilis by the continuous and judicious use of modern antisyphilitic remedies produces a clinical and serologic cure in a large proportion of cases. With this advancement in the treatment of syphilis differences of opinion have arisen regarding the influence of modern antisyphilitic drugs on the course of the disease, and the medical literature is replete with articles in which the various phases of this complex problem are discussed. Some observers have argued that since the introduction of arsphenamine there has been an increase in the incidence of late visceral manifestations of syphilis and References 1. Stokes, J. H.; Cole, H. N.; Moore, J. E.; O'Leary, P. A.; Wile, U. J.; Parran, T., Jr.; Vonderlehr, R. A, and Usilton, L. J.: Standard Treatment Procedure in Early Syphilis , J. A. M. A. 102:1267-1272 ( (April 21) ) 1934.Crossref 2. Moore, J. E., and Robinson, H. M.: Question of Arsphenamine-Resistant Syphilis , Arch. Dermat. & Syph. 21:32-39 ( (Jan.) ) 1930. 3. Miller, Thomas H.: Problem of Arsphenamine-Resistant Syphilis: Report of a Case , J. A. M. A. 97:11-14 ( (July 4) ) 1931. 4. Moore, Joseph Earle: The Modern Treatment of Syphilis , Springfield, Ill., Charles C. Thomas, Publisher, 1933, pp. 38, 204 and 249. 5. Moore, J. E., and Kemp, J. E.: Treatment of Early Syphilis: Wassermann Reaction in Treated Early Syphilis , Bull. Johns Hopkins Hosp. 39:36-55 ( (July) ) 1926. 6. Wile, U. J.; Wieder, L., and Warthin, A. S.: Malignant Syphilis with New Explanation of Pathology of Cutaneous Lesions , Am. J. Syph. & Neurol. 14: 1-34 ( (Jan.) ) 1930. 7. Gadrat, J.: Syphilis maligne totalement anergique et mortelle , Ann. de dermat. et syph. 5:990-1008 ( (Nov.) ) 1934. 8. Milian, G.: Syphilis maligne précoce , Rev. franç. de dermat. et de vénéréol. 6:336-348 ( (June) ) 1930 9. Syphilis maligne précoce: Manifestations ulcéreuses ultérieures , Milian Rev. franç. de dermat. et de vénéréol. 6:266-268 ( (May) ) 1930. 10. Sylvestre, P.: Case of Early Malignant Syphilis , Rev. méd. de la Suisse Rom. 43:172-177 ( (March) ) 1923. 11. Lacapère and Decrop: Le syndrome malin dans la syphilis , Paris méd. 35:203-208, 1920. 12. The Reticulo-Endothelial System and Chemotherapy, editorial, J. Chemotherapy 8:120-124 ( (Jan.) ) 1932. 13. Kolmer, J. A., and Schamberg, J. F.: The Influence of Reticuloendothelial "Blockade" and Splenectomy upon Experimental Trypanosomiasis and Syphilis and the Chemotherapeutic Properties of Arsphenamine and Neoarsphenamine , Am. J. Syph. & Neurol. 17:176-187 ( (April) ) 1933. 14. Yorke, W.: Drug-Resistance , Brit. J. Ven. Dis. 9:83-109 ( (April) ) 1933. 15. Akatsu, S., and Noguchi, H.: The Drug-Fastness of Spirochetes to Arsenic, Mercurial and Iodide Compounds in Vitro , J. Exper. Med. 25:351-362, 1917. 16. Klauder, J. V.: Experimental Production of an Arsenic Resistant Strain of Spirochaeta Pallida in Rabbits , Arch. Dermat. & Syph. 9:446-458 ( (April) ) 1924. 17. Greenbaum, Sigmund S., and Rule, Anna M.: Resistant Syphilis, with Especial Reference to an Attempt to Produce Experimentally an Arsenic-Resistant Strain of Spirochaeta Pallida , Pennsylvania M. J. 39:339-343 ( (Feb.) ) 1936. 18. Hoffmann and Armuzzi, cited by Moore and Robinson.2 19. Nothaas, cited by Moore and Robinson.2 20. Beerman, Herman: Problem of Treatment-Resistant Syphilis, with Special Reference to Arsphenamine-Resistant Syphilis: Review of Literature and Experimental Study , Am. J. Syph., Gonor. & Ven. Dis. 20:296-334 ( (May) ) 1936. 21. Kloeppel, F. W.: Salvarsanresistenter Spirochätenstamm bei einem Ehepaar , München. med. Wchnschr. 73:1936-1937 ( (Nov.) ) 1926. 22. Nicolas, J.; Massia, G., and Lacassagne, J.: Sur la fréquence croissante des syphilis arséno-résistantes dans la région lyonnaise , Bull. Soc. franç. de dermat. et syph. 35:132-138 ( (Feb.) ) 1928. 23. Nicolas, J.; Lacassagne, J., and Froment, R.: Les syphilis novarsénorésistantes: Etude clinique et pathogénique; déductions pratiques , Presse méd. 38:513-516 ( (April 16) ) 1930. 24. Bonnet, L. M.: Sur la fréquence actuelle des syphilis arséno-résistantes , Lyon méd. 140:229-236 ( (Sept. 4) ) 1927. 25. Jessner, M.: Syphilis Refractory to Arsphenamine , Med. Klin. 19:857-859 ( (June 24) ) 1923. 26. Lutz, W.: Zur Kenntnis der gegen Salvarsan refraktären Syphilis , Schweiz. med. Wchnschr. 50:838-841 ( (Sept. 16) ) 1920. 27. Semon, H. C. G.: Clinical Case: Salvarsan-Resistant Syphilis , Brit. J. Ven. Dis. 6:323-326, 1930. 28. Lee, D. C.: Action of Arsphenamine and Mercury on the Treponema Pallidum , Am. J. Syph. 6:546-550 ( (July) ) 1922. 29. Moore,4 p. 68. 30. Kolmer, John A.: Principles and Practice of Chemotherapy, with Special Reference to the Specific and General Treatment of Syphilis , Philadelphia, W. B. Saunders Company, 1926, pp. 25-26. 31. Dale, H. H.: Chemotherapy , Physiol. Rev. 3:359-393 ( (July) ) 1923. 32. Gouin, J.; Bienvenue, A., and Ezel, J.: Nouveau cas de syphilis arsénorésistante prévue par la leucocyto-réaction , Bull. Soc. franç. de dermat. et syph. 41: 675-678 ( (April) ) 1934. 33. Stokes, John H.: Modern Clinical Syphilology, Philadelphia , W. B. Saunders Company, 1928, p. 24. 34. Wile, Udo J., and Shaw, J. W.: The Prenatal Treatment of Syphilis with Especial Reference to Early Syphilis in the Mother , J. A. M. A. 95:1791-1795 ( (Dec. 13) ) 1930.Crossref 35. Brown, W. H., and Pearce, Louise: Reaction of Pregnant and Lactating Females to Inoculation with Treponema Pallidum: A Preliminary Note , Am. J. Syph. 4:593 ( (Oct.) ) 1920. 36. Ingraham, Norman R., Jr., and Kahler, James E.: Diagnosis and Treatment of Syphilis Complicating Pregnancy , Am. J. Obst. & Gynec. 27:134-152 ( (Jan.) ) 1934. 37. Cole, H. N.; Moore, J. E.; O'Leary, P.; Stokes, J. H.; Wile, U. J.; Clark, T.; Parran, T.; Vonderlehr, R. A., and Usilton, L. J.: Cooperative Clinical Studies in the Treatment of Syphilis: Syphilis in Pregnancy , J. A. M. A. 106:464-467 ( (Feb. 8) ) 1936. 38. Halloran, C. R.: Syphilis and Pregnancy: Effect, Diagnosis, Treatment and Complications with Report of Unusual Nitritoid Crisis , Am. J. Syph. & Neurol. 14:222-230 ( (April) ) 1930. 39. Foerster, O. H.; McIntosh, R. L.; Wieder, L. M.; Foerster, H. R., and Cooper, G. A.: Mapharsen in the Treatment of Syphilis: A Preliminary Report , Arch. Dermat. & Syph. 32:868-889 ( (Dec.) ) 1935. 40. Dennie, C. C., and McBride, W. L.: Treatment of Resistant Somatic Syphilis , Arch. Dermat. & Syph. 30:1-5 ( (July) ) 1934. 41. Dennie, C. C.: Method of Increasing Specific Resistance of Syphilitic Individual to His Disease , South. M. J. 25:462-467 ( (May) ) 1932. 42. Hench, P. S.; Slocumb, C. H., and Popp, W. C.: Fever Therapy: Results for Gonorrheal Arthritis, Chronic Infectious (Atrophic) Arthritis and Other Forms of "Rheumatism," J. A. M. A. 104:1779-1790 ( (May 18) ) 1935. 43. Dennie, C. C.; Polsky, M., and Lemoine, A. N.: Hyperpyrexia Produced by the Hot Bath in the Treatment of Syphilis , J. Missouri M. A. 33:1-12 ( (Jan.) ) 1936.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Apr 1, 1937

References

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