Abstract Arsphenamine dermatitis is always feared as a complication in the intensive treatment of syphilis. Accidents of this type are comparatively rare, yet serious reactions present a therapeutic problem which all dermatologists hate to encounter. Franklin,1 citing Harrison, stated that there were 370 cases of mild and severe arsphenamine dermatitis occurring in a total of 39,377 treated syphilitic patients during the Great War, or an incidence of this type of complication of 0.9 per cent. Harrison admitted that this figure is probably a little higher than that found in private practice. The Milian syndrome was unknown at that time. It is estimated that the percentage of patients who exhibit arsphenamine dermatitis is between 0.5 and 0.9. The percentage of deaths from arsphenamine dermatitis is surprisingly low. In Harrison's series of 370 patients, 18, or 5 per cent, died. This figure represents a fair average of the number of deaths References 1. Franklin, John L.: Salvarsan Dermatitis , Brit. J. Dermat. 42:165, 1930.Crossref 2. Christianson, O. O.: Arsenic Necrosis of the Stomach After Intravenous Injection of Neoarsphenamine , Arch. Path. 20:891 ( (Dec.) ) 1935. 3. Petrie, E., in Henke, F., and Lubarsch, O.: Handbuch der speziellen pathologischen Anatomie und Histologie , Berlin, Julius Springer, 1930. 4. Smith, C. Morton: Severe Bleeding and Purpura Following the Administration of Neoarsphenamine , Arch. Dermat. & Syph. 11:237 ( (Feb.) ) 1925. 5. O'Leary, Paul A., and Conner, H. Milton: Am. J. Syph. 9:262, 1925 6. Combes, F. C., Jr.: Purpura Hemorrhagica Following Sulpharsphenamine , Arch. Dermat. & Syph. 15:194 ( (Feb.) ) 1927 7. Stokes, John H.: Modern Clinical Syphilology , Philadelphia, W. B. Saunders Company, 1934. 8. Moore, Joseph E.: Modern Treatment of Syphilis , Springfield, Ill., Charles C. Thomas, Publisher, 1933. 9. Wilkinson, S. J., and Dodd, K.: Severe Granulocytic Aplasia of the Bone Marrow , J. A. M. A. 90:663 ( (March 3) ) 1928. 10. Jacquelin, A.; Célice, J., and Langlois: Post-arsenobenzole agranulocytosis , Bull. et mém. Soc. méd. d. hôp. de Paris 53:8 ( (Jan. 21) ) 1929. 11. Osborne, Earle D.: Microchemical Studies of Arsenic in Arsenical Dermatitis , Arch. Dermat. & Syph. 12:773 ( (Dec.) ) 1925 12. 18:37 (July) 1928. 13. Pistorius, Hugo: Arch. f. exper. Path. u. Pharmakol. 16:188, 1882. 14. Unterberger and Boehm: Arch. f. exper. Path. u. Pharmakol. 2:89, 1874. 15. Black, Noble: An Unusual Reaction Following Arsenical Treatment of Syphilis , Canad. M. A. J. 22:673, 1930. 16. Phelps, J. R., and Washburn, W. A.: Urol. & Cutan. Rev. 34:458, 1930.
Archives of Dermatology and Syphilology – American Medical Association
Published: Apr 1, 1937
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