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Are Neutrophilic Dermatoses During Granulocytopenia Really Neutrophilic?-Reply

Are Neutrophilic Dermatoses During Granulocytopenia Really Neutrophilic?-Reply Abstract We thank Misery et al for their comments regarding our article and the interesting hypothesis that is raised. They wonder if the patients with the neutrophilic dermatoses occurring during granulocytopenia, whom we described, did not have, in reality, an infiltration of dermal dendrocytes instead of polymorphonuclear neutrophils. This relies on the description of a patient presenting with the clinical features of Sweet syndrome, in which immunohistochemistry disclosed the presence of CD68+ XIIIa+ cells in the dermis.1 Of note, the morphology of the infiltrating cells in this article is not given in detail and in the absence of one of the major criteria for Sweet syndrome, the precise diagnosis remains uncertain. In the series by Jordaan, as discussed by Misery et al, neutrophils were present in 52 of 54 cases and were the prominent cell type in at least 36 of 54 cases.2 In contrast, histiocytes were prominent in References 1. Misery L, Blanc L, Perrot JL, et al. Syndrome de Sweet au cours d'une agranulocytose: hypothèse pathogénique . Ann Dermatol Venereol. 1994;121:414-415. 2. Jordaan HF. Acute febrile neutrophilic dermatosis: a histopathological study of 37 patients and a review of the literature . Am J Dermatopathol. 1989;11: 99-111.Crossref 3. Delabie J, DeWolf-Peeters C, Morren M, Marien K, Roskams T, Desmet V. Histiocytes in Sweet syndrome . Br J Dermatol. 1991;124:348-353.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Are Neutrophilic Dermatoses During Granulocytopenia Really Neutrophilic?-Reply

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Publisher
American Medical Association
Copyright
Copyright © 1996 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1996.03890310120023
Publisher site
See Article on Publisher Site

Abstract

Abstract We thank Misery et al for their comments regarding our article and the interesting hypothesis that is raised. They wonder if the patients with the neutrophilic dermatoses occurring during granulocytopenia, whom we described, did not have, in reality, an infiltration of dermal dendrocytes instead of polymorphonuclear neutrophils. This relies on the description of a patient presenting with the clinical features of Sweet syndrome, in which immunohistochemistry disclosed the presence of CD68+ XIIIa+ cells in the dermis.1 Of note, the morphology of the infiltrating cells in this article is not given in detail and in the absence of one of the major criteria for Sweet syndrome, the precise diagnosis remains uncertain. In the series by Jordaan, as discussed by Misery et al, neutrophils were present in 52 of 54 cases and were the prominent cell type in at least 36 of 54 cases.2 In contrast, histiocytes were prominent in References 1. Misery L, Blanc L, Perrot JL, et al. Syndrome de Sweet au cours d'une agranulocytose: hypothèse pathogénique . Ann Dermatol Venereol. 1994;121:414-415. 2. Jordaan HF. Acute febrile neutrophilic dermatosis: a histopathological study of 37 patients and a review of the literature . Am J Dermatopathol. 1989;11: 99-111.Crossref 3. Delabie J, DeWolf-Peeters C, Morren M, Marien K, Roskams T, Desmet V. Histiocytes in Sweet syndrome . Br J Dermatol. 1991;124:348-353.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1996

References