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Apparent Ketoconazole Failure in Candidal Cholecystitis

Apparent Ketoconazole Failure in Candidal Cholecystitis Abstract • Fungal acalculous cholecystitis is a rarely recognized complication of disseminated candidal infections. We report such a case of systemic candidiasis that developed in a man who was diabetic while he was receiving broad-spectrum antibiotic therapy for an infected foot ulcer. Ketoconazole, a new imidazole antifungal agent, was used successfully to treat the systemic candidal infection but it failed to eradicate the fungus in the biliary tract. (Arch Intern Med 1982;142:1934-1935) References 1. Edwards JE Jr (moderator): Severe candidal infections: Clinical perspective, immune defense mechanisms and current concepts of therapy. Ann Intern Med 1978;89:91-106.Crossref 2. Glenn F: Acute acalculous cholecystitis. Ann Surg 1979;189:458-465. 3. Long TN, Heimbach DM, Carrico CJ: Acalculous cholecystitis in critically ill patients. Am J Surg 1978;136:31-37.Crossref 4. Louria DB, Stiff DP, Bennett B: Disseminated moniliasias in the adult. Medicine 1962;41:307-337.Crossref 5. Eras P, Goldstein MJ, Sherlock P: Candida infection of the gastrointestinal tract. Medicine 1972;51:367-379.Crossref 6. Hermanek P: Zur Mykologie der Galle bzw. Gallenblase: II. Mitteilung: Histologische Untersuchungen. Langenbecks Arch Chir 1965;310: 137-159. 7. Huguenard P, Lafaix C, Duval J, et al: Evolutive chronic polyarthritis: Tetanus, septicemia and cholecystitis caused by Candida: Two months of intensive care followed by cure. Ann Med Interne 1971;122:619-622. 8. Miller DD: Postoperative acalculous cholecystitis due to Torulopsis glabrata. Arch Surg 1976;111:1404-1405.Crossref 9. Magnussen CR, Olson JP, Ona FU, et al: Candida fungus balls in the common bile duct. Arch Intern Med 1979;139:821-822.Crossref 10. Marcucci RA, Whitley H, Armstrong D: Common bile duct obstruction secondary to infection with Candida. J Clin Microbiol 1978;7:490-492. 11. Edwards JE Jr, Foos RY, Montgomerie JZ, et al: Ocular manifestations of Candida septicemia: Review of 76 cases of hematogenous Candida endophthalmitis. Medicine 1974;53:47-75.Crossref 12. Edwards JE Jr, Montgomerie JZ, Foos RY, et al: Experimental hematogenous endophthalmitis caused by Candida albicans. J Infect Dis 1975;131:649-657.Crossref 13. Kirkpatrick CH, Petersen EA, Ailing DW: Treatment of chronic mucocutaneous candidosis with ketoconazole: Preliminary results of a controlled, double-blind clinical trial. Rev Infect Dis 1980;2:599-600.Crossref 14. Heel RC: Systemic candidosis and candiduria , in Levine HB (ed): Ketoconazole in the Management of Fungal Disease. Sydney, Australia, ADIS Press, 1982, pp 116-118. 15. Craven PC, Ludden TM, Drutz DJ, et al: Excretion pathways of amphotericin B. J Infect Dis 1979;140:329-341.Crossref 16. Hughes WT: Systemic candidiasis: A study of 109 fatal cases. Pediatr Infect Dis 1982;1:11-18.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Apparent Ketoconazole Failure in Candidal Cholecystitis

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1982.00340230182031
Publisher site
See Article on Publisher Site

Abstract

Abstract • Fungal acalculous cholecystitis is a rarely recognized complication of disseminated candidal infections. We report such a case of systemic candidiasis that developed in a man who was diabetic while he was receiving broad-spectrum antibiotic therapy for an infected foot ulcer. Ketoconazole, a new imidazole antifungal agent, was used successfully to treat the systemic candidal infection but it failed to eradicate the fungus in the biliary tract. (Arch Intern Med 1982;142:1934-1935) References 1. Edwards JE Jr (moderator): Severe candidal infections: Clinical perspective, immune defense mechanisms and current concepts of therapy. Ann Intern Med 1978;89:91-106.Crossref 2. Glenn F: Acute acalculous cholecystitis. Ann Surg 1979;189:458-465. 3. Long TN, Heimbach DM, Carrico CJ: Acalculous cholecystitis in critically ill patients. Am J Surg 1978;136:31-37.Crossref 4. Louria DB, Stiff DP, Bennett B: Disseminated moniliasias in the adult. Medicine 1962;41:307-337.Crossref 5. Eras P, Goldstein MJ, Sherlock P: Candida infection of the gastrointestinal tract. Medicine 1972;51:367-379.Crossref 6. Hermanek P: Zur Mykologie der Galle bzw. Gallenblase: II. Mitteilung: Histologische Untersuchungen. Langenbecks Arch Chir 1965;310: 137-159. 7. Huguenard P, Lafaix C, Duval J, et al: Evolutive chronic polyarthritis: Tetanus, septicemia and cholecystitis caused by Candida: Two months of intensive care followed by cure. Ann Med Interne 1971;122:619-622. 8. Miller DD: Postoperative acalculous cholecystitis due to Torulopsis glabrata. Arch Surg 1976;111:1404-1405.Crossref 9. Magnussen CR, Olson JP, Ona FU, et al: Candida fungus balls in the common bile duct. Arch Intern Med 1979;139:821-822.Crossref 10. Marcucci RA, Whitley H, Armstrong D: Common bile duct obstruction secondary to infection with Candida. J Clin Microbiol 1978;7:490-492. 11. Edwards JE Jr, Foos RY, Montgomerie JZ, et al: Ocular manifestations of Candida septicemia: Review of 76 cases of hematogenous Candida endophthalmitis. Medicine 1974;53:47-75.Crossref 12. Edwards JE Jr, Montgomerie JZ, Foos RY, et al: Experimental hematogenous endophthalmitis caused by Candida albicans. J Infect Dis 1975;131:649-657.Crossref 13. Kirkpatrick CH, Petersen EA, Ailing DW: Treatment of chronic mucocutaneous candidosis with ketoconazole: Preliminary results of a controlled, double-blind clinical trial. Rev Infect Dis 1980;2:599-600.Crossref 14. Heel RC: Systemic candidosis and candiduria , in Levine HB (ed): Ketoconazole in the Management of Fungal Disease. Sydney, Australia, ADIS Press, 1982, pp 116-118. 15. Craven PC, Ludden TM, Drutz DJ, et al: Excretion pathways of amphotericin B. J Infect Dis 1979;140:329-341.Crossref 16. Hughes WT: Systemic candidiasis: A study of 109 fatal cases. Pediatr Infect Dis 1982;1:11-18.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Oct 1, 1982

References