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Antitrypsin Deficiency vs Gianotti-Crosti Syndrome

Antitrypsin Deficiency vs Gianotti-Crosti Syndrome Abstract To the Editor.— I read with interest the article "α1-Antitrypsin Deficiency Associated With Persistent Cutaneous Vasculitis," in the Archives (114:921-924, 1978). Drs Brandrup and Ostergaard described a 2-year-old girl who had a nonpruritic generalized rash associated with protracted neonatal jaundice. The rash consisted of red papules that were particularly dense on the face and the extensor aspect of the limbs. It was determined by the authors that the 2-year-old child had a deficiency of α1-antitrypsin, which is sometimes associated with neonatal cholestasis and progresssive cirrhosis.It occurred to me that the clinical description of this patient's cutaneous eruption and liver involvement is suggestive of the Gianotti-Crosti syndrome. The Gianotti-Crosti syndrome, also known as acrodermatitis papulosa infantalis, consists of nonpruritic red papules appearing on the legs, thighs, buttocks, extensor aspects of the arms, and face. Occasionally a few lesions are seen on the trunk also. Purpuric staining References 1. Rook A, Wilkinson DS, Ebline FJE: Textbook of Dermatology . London, Blackwell Scientific Publications, 1975, p 600. 2. Domonkos AN: Andrews' Diseases of the Skin . Philadelphia, WB Saunders Co, 1971, p 237. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Antitrypsin Deficiency vs Gianotti-Crosti Syndrome

Archives of Dermatology , Volume 115 (5) – May 1, 1979

Antitrypsin Deficiency vs Gianotti-Crosti Syndrome

Abstract

Abstract To the Editor.— I read with interest the article "α1-Antitrypsin Deficiency Associated With Persistent Cutaneous Vasculitis," in the Archives (114:921-924, 1978). Drs Brandrup and Ostergaard described a 2-year-old girl who had a nonpruritic generalized rash associated with protracted neonatal jaundice. The rash consisted of red papules that were particularly dense on the face and the extensor aspect of the limbs. It was determined by the authors that the...
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Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1979.04010050064039
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— I read with interest the article "α1-Antitrypsin Deficiency Associated With Persistent Cutaneous Vasculitis," in the Archives (114:921-924, 1978). Drs Brandrup and Ostergaard described a 2-year-old girl who had a nonpruritic generalized rash associated with protracted neonatal jaundice. The rash consisted of red papules that were particularly dense on the face and the extensor aspect of the limbs. It was determined by the authors that the 2-year-old child had a deficiency of α1-antitrypsin, which is sometimes associated with neonatal cholestasis and progresssive cirrhosis.It occurred to me that the clinical description of this patient's cutaneous eruption and liver involvement is suggestive of the Gianotti-Crosti syndrome. The Gianotti-Crosti syndrome, also known as acrodermatitis papulosa infantalis, consists of nonpruritic red papules appearing on the legs, thighs, buttocks, extensor aspects of the arms, and face. Occasionally a few lesions are seen on the trunk also. Purpuric staining References 1. Rook A, Wilkinson DS, Ebline FJE: Textbook of Dermatology . London, Blackwell Scientific Publications, 1975, p 600. 2. Domonkos AN: Andrews' Diseases of the Skin . Philadelphia, WB Saunders Co, 1971, p 237.

Journal

Archives of DermatologyAmerican Medical Association

Published: May 1, 1979

References

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