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Antithrombin, Prekallikrein, and Fibronectin Levels in Surgical Patients

Antithrombin, Prekallikrein, and Fibronectin Levels in Surgical Patients Abstract • Antithrombin (AT), prekallikrein (PK), and fibronectin (FN) levels were measured in the plasma of 290 patients. The mean (± SD) lowest AT level measured in 287 patients was 70% ± 18% (normal, 75% to 120% of control). The mean lowest AT level in 81 septic patients (49% ± 17%) was significantly lower than in the 206 patients without sepsis (78% ± 22%). The mean AT level in 60 patients who died (42% ± 22%) was significantly lower than in 227 patients who lived (78% ± 19%). The mean lowest PK level measured in 71 patients was 42% ± 17% (normal, 80% to 120%). The mean PK level in 32 septic patients (26% ± 12%) was significantly lower than in 39 patients who were not septic (54% ± 19%). The mean lowest FN level measured in 45 patients was 193 ± 86 μg/mL (normal, 160 to 240 μg/mL). The mean FN level in 15 septic patients (128 ± 72 μg/mL) was significantly lower than in the 30 nonseptic patients (266± 84 μg/mL). Following AT, PK, and FN levels in critically ill surgical patients may allow earlier diagnosis and more effective treatment of sepsis. (Arch Surg 1986;121:635-640) References 1. Mammen EF, Miyakawa T, Phillips TF, et al: Human antithrombin concentrates and experimental disseminated intravascular coagulation . Semin Thromb Haemost 1985;11:373-383.Crossref 2. Highsmith RF, Rosenberg RD: The inhibition of human plasmin by human antithrombin-heparin cofactor . J Biol Chem 1974;249:4335-4338. 3. Deutsch E, Dragosics B, Kopsa H, et al: Prekallikrein, HMW-kininogen and factor XII in various disease states . Thromb Res 1983;31: 351-364.Crossref 4. Kalter ES, Bouma BN: The kallikrein-kinin system during bacterial shock . Thromb Haemost 1981;46:9-14. 5. Doran JE: A critical assessment of fibronectin's opsonic role for bacteria and microaggregates . Vox Sang 1983;45:337-348.Crossref 6. D'Ardenne JA, McGee O'D: Fibronectin in disease . J Pathol 1984;142: 235-251.Crossref 7. Bick RL: Clinical relevance of antithrombin III . Semin Thromb Hemost 1982;8:276-287.Crossref 8. Matsumoto K, Yamamoto T, Kamata R, et al: Pathogenesis of serratial infection: Activation of the Hageman factor—prekallikrein cascade by serratial protease . J Biochem 1984;96:739-749. 9. Zerlauth G, Wolf G: Plasma fibronectin as a marker for cancer and other diseases . Am J Med 1984;77:685-689.Crossref 10. Grossman JE, Demling RH, Duy Nguyen D, et al: Response of plasma fibronectin to major body burn . J Trauma 1980;20:967-970.Crossref 11. Kluft C: Determination of prekallikrein in human plasma: Optimal conditions for activating prekallikrein . J Lab Clin Med 1978;91:83-95. 12. Mosher DF, Williams EM: Fibronectin concentrations decreased in plasma of severely ill patients with disseminated intravascular coagulation . J Lab Clin Invest 1978;91:729-735. 13. Weisel RD, Vito L, Dennis RC, et al: Myocardial depression during sepsis . Am J Surg 1977;133:512-521.Crossref 14. Wolk LA, Wilson RF, Burdick M, et al: Changes in antithrombin, antiplasmin and plasminogen during and after cardiopulmonary bypass . Am Surg 1985;51:309-313. 15. Lämmle B, Tran Tri H, Ritz R, et al: Plasma prekallikrein, factor XII, antithrombin III, C1-inhibitor and α2-macroglobulin in critically ill patients with suspected disseminated intravascular coagulation (DIC) . Am J Clin Pathol 1984;82:396-404. 16. Kalter ES, van Dijk WC, Timmerman A, et al: Activation of purified human plasma prekallikrein triggered by cell wall fractions of E coli and Staphylococcus aureus . J Infect Dis 1983;148:682-691.Crossref 17. Scovill WA, Saba TM, Kaplan JE, et al: Deficits in reticuloendothelial humoral control mechanisms in patients after trauma . J Trauma 1976;16: 898-904.Crossref 18. Saba TM, Blumenstock FA, Scovill WA, et al: Cryoprecipitate reversal of opsonic α2-surface binding glycoprotein deficiency in septic surgical and trauma patients . Science 1978;201:622-624.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Antithrombin, Prekallikrein, and Fibronectin Levels in Surgical Patients

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Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1986.01400060029002
Publisher site
See Article on Publisher Site

Abstract

Abstract • Antithrombin (AT), prekallikrein (PK), and fibronectin (FN) levels were measured in the plasma of 290 patients. The mean (± SD) lowest AT level measured in 287 patients was 70% ± 18% (normal, 75% to 120% of control). The mean lowest AT level in 81 septic patients (49% ± 17%) was significantly lower than in the 206 patients without sepsis (78% ± 22%). The mean AT level in 60 patients who died (42% ± 22%) was significantly lower than in 227 patients who lived (78% ± 19%). The mean lowest PK level measured in 71 patients was 42% ± 17% (normal, 80% to 120%). The mean PK level in 32 septic patients (26% ± 12%) was significantly lower than in 39 patients who were not septic (54% ± 19%). The mean lowest FN level measured in 45 patients was 193 ± 86 μg/mL (normal, 160 to 240 μg/mL). The mean FN level in 15 septic patients (128 ± 72 μg/mL) was significantly lower than in the 30 nonseptic patients (266± 84 μg/mL). Following AT, PK, and FN levels in critically ill surgical patients may allow earlier diagnosis and more effective treatment of sepsis. (Arch Surg 1986;121:635-640) References 1. Mammen EF, Miyakawa T, Phillips TF, et al: Human antithrombin concentrates and experimental disseminated intravascular coagulation . Semin Thromb Haemost 1985;11:373-383.Crossref 2. Highsmith RF, Rosenberg RD: The inhibition of human plasmin by human antithrombin-heparin cofactor . J Biol Chem 1974;249:4335-4338. 3. Deutsch E, Dragosics B, Kopsa H, et al: Prekallikrein, HMW-kininogen and factor XII in various disease states . Thromb Res 1983;31: 351-364.Crossref 4. Kalter ES, Bouma BN: The kallikrein-kinin system during bacterial shock . Thromb Haemost 1981;46:9-14. 5. Doran JE: A critical assessment of fibronectin's opsonic role for bacteria and microaggregates . Vox Sang 1983;45:337-348.Crossref 6. D'Ardenne JA, McGee O'D: Fibronectin in disease . J Pathol 1984;142: 235-251.Crossref 7. Bick RL: Clinical relevance of antithrombin III . Semin Thromb Hemost 1982;8:276-287.Crossref 8. Matsumoto K, Yamamoto T, Kamata R, et al: Pathogenesis of serratial infection: Activation of the Hageman factor—prekallikrein cascade by serratial protease . J Biochem 1984;96:739-749. 9. Zerlauth G, Wolf G: Plasma fibronectin as a marker for cancer and other diseases . Am J Med 1984;77:685-689.Crossref 10. Grossman JE, Demling RH, Duy Nguyen D, et al: Response of plasma fibronectin to major body burn . J Trauma 1980;20:967-970.Crossref 11. Kluft C: Determination of prekallikrein in human plasma: Optimal conditions for activating prekallikrein . J Lab Clin Med 1978;91:83-95. 12. Mosher DF, Williams EM: Fibronectin concentrations decreased in plasma of severely ill patients with disseminated intravascular coagulation . J Lab Clin Invest 1978;91:729-735. 13. Weisel RD, Vito L, Dennis RC, et al: Myocardial depression during sepsis . Am J Surg 1977;133:512-521.Crossref 14. Wolk LA, Wilson RF, Burdick M, et al: Changes in antithrombin, antiplasmin and plasminogen during and after cardiopulmonary bypass . Am Surg 1985;51:309-313. 15. Lämmle B, Tran Tri H, Ritz R, et al: Plasma prekallikrein, factor XII, antithrombin III, C1-inhibitor and α2-macroglobulin in critically ill patients with suspected disseminated intravascular coagulation (DIC) . Am J Clin Pathol 1984;82:396-404. 16. Kalter ES, van Dijk WC, Timmerman A, et al: Activation of purified human plasma prekallikrein triggered by cell wall fractions of E coli and Staphylococcus aureus . J Infect Dis 1983;148:682-691.Crossref 17. Scovill WA, Saba TM, Kaplan JE, et al: Deficits in reticuloendothelial humoral control mechanisms in patients after trauma . J Trauma 1976;16: 898-904.Crossref 18. Saba TM, Blumenstock FA, Scovill WA, et al: Cryoprecipitate reversal of opsonic α2-surface binding glycoprotein deficiency in septic surgical and trauma patients . Science 1978;201:622-624.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Jun 1, 1986

References