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Antiretroviral Therapy and the Prevalence and Incidence of Diabetes

Antiretroviral Therapy and the Prevalence and Incidence of Diabetes In the study by Brown et al,1 the authors did not mention several limitations that might have an important impact on the interpretation of the results. First, the study only included men, who were mostly white (approximately 86%). Therefore, the results cannot be extrapolated to women and other ethnic groups. Second, the family history of diabetes was not ascertained in the study participants, and this could have confounded the magnitude of differences in prevalence and incidence of diabetes between the 2 study groups. Third, the reported prevalence and incidence rates of diabetes were likely to be overestimated because the diagnosis of diabetes was not confirmed by a repeated measurement of fasting plasma glucose. In addition, the article1 suffered from multiple errors in the organization of the references that led to significant confusion and sometimes difficulty in following the manuscript. In fact, several references mentioned in the text did not match the references listed at the end of the article. Thus, reference numbers 5, 6, 7, 8, 9, 11, 12, 15, and 26 in the text were misplaced and corresponded to reference numbers 7, 8, 9, 1, 10, 12, 11, 16, and 27, respectively, in the list of references.1 Finally, the publication year of the study by Walli et al,2 reference number 7 in the list of references,1 is 1998 and not 2001. Correspondence: Dr Mikhail, Department of Medicine, Olive View–UCLA Medical Center, 14445 Olive View Dr, Sylmar, CA 91342-1495 (n.mikhail@ladhs.org). References 1. Brown TTCole SRLi X et al. Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS Cohort Study. Arch Intern Med 2005;1651179- 1184PubMedGoogle ScholarCrossref 2. Walli RHertfort OMichl GM et al. Treatment with protease inhibitors associated with peripheral insulin resistance and impaired oral glucose tolerance in HIV-1-infected patients. AIDS 1998;12F167- F173PubMedGoogle ScholarCrossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Antiretroviral Therapy and the Prevalence and Incidence of Diabetes

Mikhail, Nasser; Cope, Dennis
Archives of Internal Medicine , Volume 165 (21) – Nov 28, 2005
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Publisher
American Medical Association
Copyright
Copyright © 2005 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.165.21.2536-c
Publisher site
See Article on Publisher Site

Abstract

In the study by Brown et al,1 the authors did not mention several limitations that might have an important impact on the interpretation of the results. First, the study only included men, who were mostly white (approximately 86%). Therefore, the results cannot be extrapolated to women and other ethnic groups. Second, the family history of diabetes was not ascertained in the study participants, and this could have confounded the magnitude of differences in prevalence and incidence of diabetes between the 2 study groups. Third, the reported prevalence and incidence rates of diabetes were likely to be overestimated because the diagnosis of diabetes was not confirmed by a repeated measurement of fasting plasma glucose. In addition, the article1 suffered from multiple errors in the organization of the references that led to significant confusion and sometimes difficulty in following the manuscript. In fact, several references mentioned in the text did not match the references listed at the end of the article. Thus, reference numbers 5, 6, 7, 8, 9, 11, 12, 15, and 26 in the text were misplaced and corresponded to reference numbers 7, 8, 9, 1, 10, 12, 11, 16, and 27, respectively, in the list of references.1 Finally, the publication year of the study by Walli et al,2 reference number 7 in the list of references,1 is 1998 and not 2001. Correspondence: Dr Mikhail, Department of Medicine, Olive View–UCLA Medical Center, 14445 Olive View Dr, Sylmar, CA 91342-1495 (n.mikhail@ladhs.org). References 1. Brown TTCole SRLi X et al. Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS Cohort Study. Arch Intern Med 2005;1651179- 1184PubMedGoogle ScholarCrossref 2. Walli RHertfort OMichl GM et al. Treatment with protease inhibitors associated with peripheral insulin resistance and impaired oral glucose tolerance in HIV-1-infected patients. AIDS 1998;12F167- F173PubMedGoogle ScholarCrossref

Journal

Archives of Internal Medicine – American Medical Association

Published: Nov 28, 2005

Keywords: diabetes mellitus,anti-retroviral agents

References

  • Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS Cohort Study.
    Li X; Arch Intern Med
  • Treatment with protease inhibitors associated with peripheral insulin resistance and impaired oral glucose tolerance in HIV-1-infected patients.
    Michl GM; AIDS