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Antipyrine as a Model Drug Substance to Assess Oxidative Metabolism-Reply

Antipyrine as a Model Drug Substance to Assess Oxidative Metabolism-Reply Abstract We appreciate the remarks made by Cantilena and Honig in reference to our comments on antipyrine metabolism.1 In the "Comment" section, we were only speculative in stating that antipyrine metabolism may predict warfarin metabolism. Cantilena and Honig referred to one study that demonstrated little relationship between antipyrine and tolbutamide disposition when effected by known inhibitors of drug metabolism.2 We are unaware of other studies showing a similar relationship (or lack thereof) between antipyrine and warfarin. Clearly, more investigation is needed in this area before firm conclusions can be made. References 1. Crussell-Porter LL, Rindone JP, Ford MA, Jaskar DW. Low-dose fluconazole potentiates the hypothrombinemic response of warfarin sodium . Arch Intern Med . 1993;153:102-104.Crossref 2. Back DJ, Tija J, Monig H, et al. Selective inhibition of drug oxidation after simultaneous administration of two probe drugs, antipyrine and tolbutamide . Eur J Clin Pharmacol . 1988;34:157-163.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Antipyrine as a Model Drug Substance to Assess Oxidative Metabolism-Reply

Archives of Internal Medicine , Volume 154 (5) – Mar 14, 1994

Antipyrine as a Model Drug Substance to Assess Oxidative Metabolism-Reply

Abstract

Abstract We appreciate the remarks made by Cantilena and Honig in reference to our comments on antipyrine metabolism.1 In the "Comment" section, we were only speculative in stating that antipyrine metabolism may predict warfarin metabolism. Cantilena and Honig referred to one study that demonstrated little relationship between antipyrine and tolbutamide disposition when effected by known inhibitors of drug metabolism.2 We are unaware of other studies showing a similar relationship...
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Publisher
American Medical Association
Copyright
Copyright © 1994 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1994.00420050162016
Publisher site
See Article on Publisher Site

Abstract

Abstract We appreciate the remarks made by Cantilena and Honig in reference to our comments on antipyrine metabolism.1 In the "Comment" section, we were only speculative in stating that antipyrine metabolism may predict warfarin metabolism. Cantilena and Honig referred to one study that demonstrated little relationship between antipyrine and tolbutamide disposition when effected by known inhibitors of drug metabolism.2 We are unaware of other studies showing a similar relationship (or lack thereof) between antipyrine and warfarin. Clearly, more investigation is needed in this area before firm conclusions can be made. References 1. Crussell-Porter LL, Rindone JP, Ford MA, Jaskar DW. Low-dose fluconazole potentiates the hypothrombinemic response of warfarin sodium . Arch Intern Med . 1993;153:102-104.Crossref 2. Back DJ, Tija J, Monig H, et al. Selective inhibition of drug oxidation after simultaneous administration of two probe drugs, antipyrine and tolbutamide . Eur J Clin Pharmacol . 1988;34:157-163.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Mar 14, 1994

References