Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Antipsychotic Therapy and Short-term Serious Events in Older Adults With Dementia

Antipsychotic Therapy and Short-term Serious Events in Older Adults With Dementia ORIGINAL INVESTIGATION Antipsychotic Therapy and Short-term Serious Events in Older Adults With Dementia Paula A. Rochon, MD, MPH, FRCPC; Sharon-Lise Normand, PhD; Tara Gomes, MHSc; Sudeep S. Gill, MD, MSc; Geoffrey M. Anderson, MD, PhD; Magda Melo, MSc; Kathy Sykora, MSc; Lorraine Lipscombe, MD, MSc; Chaim M. Bell, MD, PhD; Jerry H. Gurwitz, MD Background: Antipsychotic therapy is widely used to els that included all covariates with a standard differ- treat behavioral problems in older adults with demen- ence greater than 0.10. tia. Cohort studies evaluating the safety of antipsy- chotic therapy generally focus on a single adverse event. Results: Relative to those who received no antipsy- We compared the rate of developing any serious event, chotic therapy, community-dwelling older adults newly a composite outcome defined as an event serious enough dispensed an atypical antipsychotic therapy were 3.2 times to lead to an acute care hospital admission or death within more likely (95% confidence interval, 2.77-3.68) and those 30 days of initiating antipsychotic therapy, to better es- who received conventional antipsychotic therapy were timate the overall burden of short-term harm associated 3.8 times more likely (95% confidence interval, 3.31- with these agents. 4.39) to develop any serious event during http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

Antipsychotic Therapy and Short-term Serious Events in Older Adults With Dementia

Download PDF
7 pages

Loading next page...
 
/lp/american-medical-association/antipsychotic-therapy-and-short-term-serious-events-in-older-adults-v95hifTBcq

References (28)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/archinte.168.10.1090
pmid
18504337
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL INVESTIGATION Antipsychotic Therapy and Short-term Serious Events in Older Adults With Dementia Paula A. Rochon, MD, MPH, FRCPC; Sharon-Lise Normand, PhD; Tara Gomes, MHSc; Sudeep S. Gill, MD, MSc; Geoffrey M. Anderson, MD, PhD; Magda Melo, MSc; Kathy Sykora, MSc; Lorraine Lipscombe, MD, MSc; Chaim M. Bell, MD, PhD; Jerry H. Gurwitz, MD Background: Antipsychotic therapy is widely used to els that included all covariates with a standard differ- treat behavioral problems in older adults with demen- ence greater than 0.10. tia. Cohort studies evaluating the safety of antipsy- chotic therapy generally focus on a single adverse event. Results: Relative to those who received no antipsy- We compared the rate of developing any serious event, chotic therapy, community-dwelling older adults newly a composite outcome defined as an event serious enough dispensed an atypical antipsychotic therapy were 3.2 times to lead to an acute care hospital admission or death within more likely (95% confidence interval, 2.77-3.68) and those 30 days of initiating antipsychotic therapy, to better es- who received conventional antipsychotic therapy were timate the overall burden of short-term harm associated 3.8 times more likely (95% confidence interval, 3.31- with these agents. 4.39) to develop any serious event during

Journal

JAMA Internal Medicine – American Medical Association

Published: May 26, 2008

There are no references for this article.