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Antipsychotic Drugs and Hyperglycemia in Older Patients With Diabetes

Antipsychotic Drugs and Hyperglycemia in Older Patients With Diabetes ORIGINAL INVESTIGATION Antipsychotic Drugs and Hyperglycemia in Older Patients With Diabetes Lorraine L. Lipscombe, MD, MSc; Linda Le´vesque, BScPharm, PhD; Andrea Gruneir, PhD; Hadas D. Fischer, MD; David N. Juurlink, BPharm, MD, PhD; Sudeep S. Gill, MD, MSc; Nathan Herrmann, MD; Janet E. Hux, MD, MSc; Geoff M. Anderson, MD, PhD; Paula A. Rochon, MD, MPH Background: Evidence suggests that there is an asso- Results: Of 13 817 patients studied, 1515 (11.0%) were ciation between antipsychotic drugs and new-onset dia- hospitalized for hyperglycemia. Current antipsychotic betes, but little is known about the risk of hyperglyce- treatment was associated with a higher risk of hypergly- mia among persons with preexisting diabetes. cemia compared with remote antipsychotic use in all dia- betes treatment groups (overall adjusted rate ratio, 1.50; Methods: Using a nested case-control design and popu- 95% confidence interval, 1.29-1.74). The risk was in- lation-based health databases in Ontario, Canada, per- creased among patients who were treated with atypical sons aged 66 years or older with diabetes who started treat- and typical antipsychotic agents and was extremely high ment with an antipsychotic drug from April 1, 2002, to among patients who were just starting treatment (only March 31, 2006, were http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

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References (37)

Publisher
American Medical Association
Copyright
Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/archinternmed.2009.207
pmid
19636029
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL INVESTIGATION Antipsychotic Drugs and Hyperglycemia in Older Patients With Diabetes Lorraine L. Lipscombe, MD, MSc; Linda Le´vesque, BScPharm, PhD; Andrea Gruneir, PhD; Hadas D. Fischer, MD; David N. Juurlink, BPharm, MD, PhD; Sudeep S. Gill, MD, MSc; Nathan Herrmann, MD; Janet E. Hux, MD, MSc; Geoff M. Anderson, MD, PhD; Paula A. Rochon, MD, MPH Background: Evidence suggests that there is an asso- Results: Of 13 817 patients studied, 1515 (11.0%) were ciation between antipsychotic drugs and new-onset dia- hospitalized for hyperglycemia. Current antipsychotic betes, but little is known about the risk of hyperglyce- treatment was associated with a higher risk of hypergly- mia among persons with preexisting diabetes. cemia compared with remote antipsychotic use in all dia- betes treatment groups (overall adjusted rate ratio, 1.50; Methods: Using a nested case-control design and popu- 95% confidence interval, 1.29-1.74). The risk was in- lation-based health databases in Ontario, Canada, per- creased among patients who were treated with atypical sons aged 66 years or older with diabetes who started treat- and typical antipsychotic agents and was extremely high ment with an antipsychotic drug from April 1, 2002, to among patients who were just starting treatment (only March 31, 2006, were

Journal

JAMA Internal MedicineAmerican Medical Association

Published: Jul 27, 2009

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