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A. Donihi, D. Raval, M. Saul, M. Korytkowski, M. Devita (2006)
Prevalence and predictors of corticosteroid-related hyperglycemia in hospitalized patients.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 12 4
E. Thonnard-Neumann (1968)
Phenothiazines and diabetes in hospitalized women.The American journal of psychiatry, 124 7
(2005)
BMC Medical Research Methodology
P. Rochon, S. Normand, T. Gomes, S. Gill, G. Anderson, Magda Melo, K. Sykora, L. Lipscombe, C. Bell, J. Gurwitz (2008)
Antipsychotic therapy and short-term serious events in older adults with dementia.Archives of internal medicine, 168 10
Lon Schneider, Pierre Tariot, K. Dagerman, S. Davis, John Hsiao, M. Ismail, Barry Lebowitz, Constantine Lyketsos, J. Ryan, T. Stroup, D. Sultzer, Daniel Weintraub, Jeffrey Lieberman (2006)
Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease.The New England journal of medicine, 355 15
G. Biessels, Salka Staekenborg, E. Brunner, C. Brayne, P. Scheltens (2006)
Risk of dementia in diabetes mellitus: a systematic reviewThe Lancet Neurology, 5
J. Hux, F. Ivis, V. Flintoft, A. Bica (2002)
Diabetes in Ontario: determination of prevalence and incidence using a validated administrative data algorithm.Diabetes care, 25 3
M. Yola, A. Lucien (1994)
Evidence of the depletion of susceptibles effect in non-experimental pharmacoepidemiologic research.Journal of Clinical Epidemiology, 47
L. Dixon, P. Weiden, J. Delahanty, R. Goldberg, L. Postrado, A. Lucksted, A. Lehman (2000)
Prevalence and correlates of diabetes in national schizophrenia samples.Schizophrenia bulletin, 26 4
A. Levy, B. O'brien, C. Sellors, P. Grootendorst, D. Willison (2003)
Coding accuracy of administrative drug claims in the Ontario Drug Benefit database.The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique, 10 2
S. Gill, S. Bronskill, S. Normand, G. Anderson, K. Sykora, K. Lam, C. Bell, Philip Lee, H. Fischer, N. Herrmann, J. Gurwitz, P. Rochon (2007)
Antipsychotic Drug Use and Mortality in Older Adults with DementiaAnnals of Internal Medicine, 146
L. Lipscombe, J. Hux (2007)
Trends in diabetes prevalence, incidence, and mortality in Ontario, Canada 1995–2005: a population-based studyThe Lancet, 369
J. Snowdon, S. Day, Wesley Baker (2005)
Why and how antipsychotic drugs are used in 40 Sydney nursing homesInternational Journal of Geriatric Psychiatry, 20
J. Micca, V. Hoffmann, I. Lipkovich, J. Ahl, R. Baker, T. Hardy (2006)
Retrospective analysis of diabetes risk in elderly patients with dementia in olanzapine clinical trials.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 14 1
E. Valiyeva, N. Herrmann, P. Rochon, S. Gill, G. Anderson (2008)
Effect of regulatory warnings on antipsychotic prescription rates among elderly patients with dementia: a population-based time-series analysisCanadian Medical Association Journal, 179
M. Rondanelli, S. Sarra, N. Antoniello, V. Mansi, Stefano Govoni, F. Falvo, S. Solerte, Ettore Ferrari (2006)
No effect of atypical antipsychotic drugs on weight gain and risk of developing type II diabetes or lipid abnormalities among nursing home elderly patients with Alzheimer's disease.Minerva medica, 97 2
S. Suissa (2002)
Novel Approaches to Pharmacoepidemiology Study Design and Statistical Analysis
John Roefaro, S. Mukherjee (2001)
Olanzapine-Induced Hyperglycemic Nonketonic Coma, 35
S. Gill, P. Rochon, N. Herrmann, Philip Lee, K. Sykora, N. Gunraj, S. Normand, J. Gurwitz, C. Marras, W. Wodchis, M. Mamdani (2005)
Atypical antipsychotic drugs and risk of ischaemic stroke: population based retrospective cohort studyBMJ : British Medical Journal, 330
R. Holt, R. Peveler (2006)
Association between antipsychotic drugs and diabetesDiabetes, 8
R. Deyo, D. Cherkin, D. Cherkin, M. Ciol (1992)
Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases.Journal of clinical epidemiology, 45 6
M. Takahashi, S. Ohishi, C. Katsumi, T. Moriya, H. Miyaoka (2005)
Rapid onset of quetiapine-induced diabetic ketoacidosis in an elderly patient: a case report.Pharmacopsychiatry, 38 4
R. Scranton, J. Gaziano, D. Rutty, M. Ezrokhi, A. Cincotta, Email Richard, E. Scranton, J. Michael
Bmc Endocrine Disorders a Randomized, Double-blind, Placebo-controlled Trial to Assess Safety and Tolerability during Treatment of Type 2 Diabetes with Usual Diabetes Therapy and Either Cycloset™ or Placebo
J. Muench, M. Carey (2001)
Diabetes mellitus associated with atypical antipsychotic medications: new case report and review of the literature.The Journal of the American Board of Family Practice, 14 4
F. Gianfrancesco, J. Pesa, Ruey-hua Wang, H. Nasrallah (2006)
Assessment of antipsychotic-related risk of diabetes mellitus in a Medicaid psychosis population: sensitivity to study design.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 63 5
M. Rapoport, M. Mamdani, K. Shulman, N. Herrmann, P. Rochon (2005)
Antipsychotic use in the elderly: shifting trends and increasing costsInternational Journal of Geriatric Psychiatry, 20
K. Bina, A. Cincotta (2000)
Dopaminergic Agonists Normalize Elevated Hypothalamic Neuropeptide Y and Corticotropin-Releasing Hormone, Body Weight Gain, and Hyperglycemia in ob/ob MiceNeuroendocrinology, 71
P. Feldman, L. Hay, W. Deberdt, J. Kennedy, D. Hutchins, D. Hay, T. Hardy, V. Hoffmann, K. Hornbuckle, A. Breier (2004)
Retrospective cohort study of diabetes mellitus and antipsychotic treatment in a geriatric population in the United States.Journal of the American Medical Directors Association, 5 1
M. Smith, David Hopkins, R. Peveler, R. Holt, M. Woodward, K. Ismail (2008)
First- v. second-generation antipsychotics and risk for diabetes in schizophrenia: systematic review and meta-analysis.The British journal of psychiatry : the journal of mental science, 192 6
K. Ramaswamy, P. Masand, H. Nasrallah (2006)
Do certain atypical antipsychotics increase the risk of diabetes? A critical review of 17 pharmacoepidemiologic studies.Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 18 3
R. Holt, R. Peveler (2006)
Antipsychotic drugs and diabetes—an application of the Austin Bradford Hill criteriaDiabetologia, 49
A. Sinclair, A. Girling, A. Bayer (2000)
Cognitive dysfunction in older subjects with diabetes mellitus: impact on diabetes self-management and use of care services. All Wales Research into Elderly (AWARE) Study.Diabetes research and clinical practice, 50 3
V Essebag, RW Platt, M Abrahamowicz, L Pilote (2005)
Comparison of nested case-control and survival analysis methodologies for analysis of time-dependent exposure., 5
B. Hiles (1956)
HYPERGLYCEMIA AND GLYCOSURIA FOLLOWING CHLORPROMAZINE THERAPYJAMA, 162
M. Etminan, D. Streiner, P. Rochon (2003)
Exploring the Association Between Atypical Neuroleptic Agents and Diabetes Mellitus in Older AdultsPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 23
D. Allison, D. Casey (2001)
Antipsychotic-induced weight gain: a review of the literature.The Journal of clinical psychiatry, 62 Suppl 7
RE Scranton, JM Gaziano, D Rutty, M Ezrokhi, A Cincotta (2007)
A randomized, double-blind, placebo-controlled trial to assess safety and tolerability during treatment of type 2 diabetes with usual diabetes therapy and either Cycloset or placebo., 7
ORIGINAL INVESTIGATION Antipsychotic Drugs and Hyperglycemia in Older Patients With Diabetes Lorraine L. Lipscombe, MD, MSc; Linda Le´vesque, BScPharm, PhD; Andrea Gruneir, PhD; Hadas D. Fischer, MD; David N. Juurlink, BPharm, MD, PhD; Sudeep S. Gill, MD, MSc; Nathan Herrmann, MD; Janet E. Hux, MD, MSc; Geoff M. Anderson, MD, PhD; Paula A. Rochon, MD, MPH Background: Evidence suggests that there is an asso- Results: Of 13 817 patients studied, 1515 (11.0%) were ciation between antipsychotic drugs and new-onset dia- hospitalized for hyperglycemia. Current antipsychotic betes, but little is known about the risk of hyperglyce- treatment was associated with a higher risk of hypergly- mia among persons with preexisting diabetes. cemia compared with remote antipsychotic use in all dia- betes treatment groups (overall adjusted rate ratio, 1.50; Methods: Using a nested case-control design and popu- 95% confidence interval, 1.29-1.74). The risk was in- lation-based health databases in Ontario, Canada, per- creased among patients who were treated with atypical sons aged 66 years or older with diabetes who started treat- and typical antipsychotic agents and was extremely high ment with an antipsychotic drug from April 1, 2002, to among patients who were just starting treatment (only March 31, 2006, were
JAMA Internal Medicine – American Medical Association
Published: Jul 27, 2009
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