Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Antimicrobial Therapy and Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis

Antimicrobial Therapy and Respiratory Hospitalization or Death in Adults With Idiopathic... Letters protocol for a randomised, controlled, open, parallel-group, phase IV study (the factor inhibitors for clinicians, researchers, and industry. When NOR-DRUM study). Trials. 2020;21(1):13. doi:10.1186/s13063-019-3734-4 appropriately designed, validated, and automated, these as- says provide low-cost, high-throughput methods that can se- lectively measure active drug concentrations. In contrast, liq- Antimicrobial Therapy and Respiratory uid chromatography mass spectrometry methods are Hospitalization or Death in Adults associated with high costs and require elaborate sample pre- With Idiopathic Pulmonary Fibrosis treatment to provide comparable information. NOR-DRUM To the Editor Of the 513 patients with idiopathic pulmonary Part A addressed the effectiveness of proactive TDM, defined fibrosis (IPF) in the CleanUP-IPF trial, 128 were random- as scheduled testing regardless of the clinical situation, with ized to receive co-trimoxazole; 126, doxycycline; and 259, the aim to keep the drug level within the therapeutic range to usual care. After a mean follow-up of 13.1 months, there prevent treatment failure, achieve timely detection of anti- was no difference in the primary outcome (time to first non- drug antibodies, and minimize overdosing. The application elective respiratory hospitalization or all-cause mortality) of TDM in treatment failure, reactive TDM, was beyond the between the groups. Based on this finding, the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Antimicrobial Therapy and Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis

JAMA , Volume 326 (11) – Sep 21, 2021

Loading next page...
 
/lp/american-medical-association/antimicrobial-therapy-and-respiratory-hospitalization-or-death-in-VfVZ69ZhSk
Publisher
American Medical Association
Copyright
Copyright 2021 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2021.11810
Publisher site
See Article on Publisher Site

Abstract

Letters protocol for a randomised, controlled, open, parallel-group, phase IV study (the factor inhibitors for clinicians, researchers, and industry. When NOR-DRUM study). Trials. 2020;21(1):13. doi:10.1186/s13063-019-3734-4 appropriately designed, validated, and automated, these as- says provide low-cost, high-throughput methods that can se- lectively measure active drug concentrations. In contrast, liq- Antimicrobial Therapy and Respiratory uid chromatography mass spectrometry methods are Hospitalization or Death in Adults associated with high costs and require elaborate sample pre- With Idiopathic Pulmonary Fibrosis treatment to provide comparable information. NOR-DRUM To the Editor Of the 513 patients with idiopathic pulmonary Part A addressed the effectiveness of proactive TDM, defined fibrosis (IPF) in the CleanUP-IPF trial, 128 were random- as scheduled testing regardless of the clinical situation, with ized to receive co-trimoxazole; 126, doxycycline; and 259, the aim to keep the drug level within the therapeutic range to usual care. After a mean follow-up of 13.1 months, there prevent treatment failure, achieve timely detection of anti- was no difference in the primary outcome (time to first non- drug antibodies, and minimize overdosing. The application elective respiratory hospitalization or all-cause mortality) of TDM in treatment failure, reactive TDM, was beyond the between the groups. Based on this finding, the

Journal

JAMAAmerican Medical Association

Published: Sep 21, 2021

References