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Antimalarials in the Treatment of Discoid Lupus Erythematosus: Special Reference to Amodiaquin (Camoquin)

Antimalarials in the Treatment of Discoid Lupus Erythematosus: Special Reference to Amodiaquin... Abstract In recent years the effective treatment of discoid lupus erythematosus has been greatly advanced by the introduction of antimalarial drugs. While this as well as former methods of treatment remain on a purely empirical basis, awaiting fuller understanding of the pathogenesis of lupus erythematosus, it is now evident that quinacrine (Atabrine) and chloroquine (Aralen) afford suppression or control of the disease more consistently than any of the older therapeutic agents. The interesting history of the employment of antimalarials for lupus erythematosus has been recounted in several recent contributions.* Chloroquine has found acceptance as being superior to quinacrine in avoiding the undesirable skin discoloration and hematologic risks of the latter. Attention now is centered upon the investigation of other antimalarial drugs in the effort to find those which are most beneficial and at the same time least toxic. The present report includes observations on the use of quinacrine, chloroquine, References 1. References 2 to 24. 2. The Camoquin was supplied through the courtesy of Dr. Eugene H. Payne of the Department of Clinical Investigation, Parke, Davis & Company, Detroit. 3. Berliner, R. W., and others: Studies on the Chemotherapy of the Human Malarias: VI. The Physiological Disposition, Antimalarial Activity and Toxicity of Several Derivatives of 4-Aminoquinoline , J. Clin. Invest. 27:98 (May, Part (2) ) 1948.Crossref 4. Black, H.: The Treatment of Lupus Erythematosus with Mepacrine and Paraaminobenzoic Acid. Brit. J. Dermat. 65:195-203 ( (June) ) 1953.Crossref 5. Cole, H. N., Jr.; Chivington, P. V., Jr.; Cole, H. N., and Driver, J. R., Jr.: Treatment of Chronic Discoid Lupus Erythematosus with Quinacrine , J. A. M. A. 153:1515-1516 ( (Dec. 26) ) 1953.Crossref 6. Cramer, J. A., and Lewis, G. M.: Atabrine in the Treatment of Discoid Lupus Erythematosus , J. Invest. Dermat. 19:393-395 ( (Dec.) ) 1952.Crossref 7. Dubois, E. L.: Quinacrine (Atabrine) in Treatment of Systemic and Discoid Lupus Erythematosus , A. M. A. Arch. Int. Med. 94:131-141 ( (July) ) 1954.Crossref 8. Farber, E. M., and Driver, I. E.: Atabrine® and Chloroquine in the Treatment of Chronic Discoid Lupus Erythematosus: A Preliminary Report , Stanford M. Bull. 11:157-161 ( (Aug.) ) 1953. 9. Goldman, L.; Cole, D. P., and Preston, R. H.: Chloroquine Diphosphate in the Treatment of Discoid Lupus Erythematosus , J. A. M. A. 152:1428-1429 ( (Aug. 8) ) 1953.Crossref 10. Hathaway, J. C.: Therapeutic Committee Evaluation Report: The Value of Atabrine Therapy in Chronic Discoid Lupus Erythematosus , Tr. Pacific Dermat. A. (6th Annual Meeting) 1:40-41, 1954. 11. Herrmann, F., and Miller, O. B.: Pharmacologic and Pathogenic Effects of Mepacrine Hydrochloride (Atabrine®) on Human Skin. I. Clinical and Experimental Observations , Acta dermat.-venereol. 32:304-316 1952. 12. II. Microscopic Studies of Vital Staining Effects in Skin , Herrmann Acta dermat.-venereol. 32:317-332, 1952. 13. Novy, F. G., Jr.: Therapeutic Committee Evaluation Report: Chloroquine Therapy and Discoid Lupus Erythematosus , Tr. Pacific Dermat. A. (6th Annual Meeting) 1:37-39, 1954. 14. Ottolenghi-Lodigiani, F.: Treatment of Chronic Lupus Erythematodes: Local Intradermal Infiltration with Acridine Preparations , Hautarzt 6:24-27 ( (Jan.) ) 1955. 15. Page, F.: Treatment of Lupus Erythematosus with Mepacrine , Lancet , 2:755-758 ( (Oct. 27) ) 1951.Crossref 16. Parmer, L. G., and Sawitsky, A.: Fatal Aplastic Anemia Following Quinacrine Therapy in Chronic Discoid Lupus Erythematosus , J. A. M. A. 153:1172-1174 ( (Nov. 28) ) 1953.Crossref 17. Pillsbury, D. M., and Jacobson, C.: Treatment of Chronic Discoid Lupus Erythematosus with Chloroquine (Aralen) J. A. M. A. 154:1330-1333 ( (April 17) ) 1954.Crossref 18. Popoff, L., and Kutinscheff: Case Presentations , Dermat. Wchnschr. 116:186, 1943. 19. Prokoptchouk, A. J.: Treatment of Lupus Erythematosus with Acriquine , Vestnik venerol. i dermat. , No. (2) -3, pp. 23-26, 1940; 20. abstracted, Zentralbl. Haut. u. Geschlechtskr. 66:112, 1940-1941. 21. Rhodes, B. L., and Allende, M. F.: Treatment of Chronic Discoid Lupus Erythematosus with Quinacrine , California Med. 80:70-71 ( (Feb.) ) 1954. 22. Rogers, J., and Finn, O. A.: Synthetic Antimalarial Drugs in Chronic Discoid Lupus Erythematosus and Light Eruptions , A. M. A. Arch. Dermat. & Syph. 70:61-66 ( (July) ) 1954. 23. Sawicky, H. H.; Kanof, N. B.; Silverberg, M. G.; Braitman, M., and Kalish, K.: Therapeutic Assays of the Skin and Cancer Unit of the New York Hospital: Assay VII. Quinacrine Hydrochloride (Atabrine Hydrochloride) for Chronic Discoid Lupus Erythematosus , J. Invest. Dermat. 19:397-404 ( (Dec.) ) 1952. 24. Sommerville, J.; Devine, D. C., and Logan, J. C. P.: Lupus Erythematosus Treated with Mepacrine , Brit. J. Dermat. 64:417-419 ( (Nov.) ) 1952.Crossref 25. Sulzberger, M. B., and Baer, R. L.: Editorial comment, The 1952 Year Book of Dermatology and Syphilology , Chicago, The Year Book Publishers, Inc., 1953, p. 92. 26. Tye, M. J.; Schiff, B. L.; Collins, S. F.; Baler, G. R., and Appel, B.: Chronic Discoid Lupus Erythematosus: Treatment with Daraprim and Chloroquin Diphosphate (Aralen) , New England J. Med. 251:52-55 ( (July 8) ) 1954.Crossref 27. Wells, G. C.: Treatment of Chronic Discoid Lupus Erythematosus with Atabrine , J. Invest. Dermat. 19:405-407 ( (Dec.) ) 1952.Crossref 28. Zakon, S. J., and Gershenson, J.: Introduction of Quinacrine in Treatment of Lupus Erythematosus , A. M. A. Arch. Dermat. 71:520-521 ( (April) ) 1955.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Antimalarials in the Treatment of Discoid Lupus Erythematosus: Special Reference to Amodiaquin (Camoquin)

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References (28)

Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1956.01550010052005
Publisher site
See Article on Publisher Site

Abstract

Abstract In recent years the effective treatment of discoid lupus erythematosus has been greatly advanced by the introduction of antimalarial drugs. While this as well as former methods of treatment remain on a purely empirical basis, awaiting fuller understanding of the pathogenesis of lupus erythematosus, it is now evident that quinacrine (Atabrine) and chloroquine (Aralen) afford suppression or control of the disease more consistently than any of the older therapeutic agents. The interesting history of the employment of antimalarials for lupus erythematosus has been recounted in several recent contributions.* Chloroquine has found acceptance as being superior to quinacrine in avoiding the undesirable skin discoloration and hematologic risks of the latter. Attention now is centered upon the investigation of other antimalarial drugs in the effort to find those which are most beneficial and at the same time least toxic. The present report includes observations on the use of quinacrine, chloroquine, References 1. References 2 to 24. 2. The Camoquin was supplied through the courtesy of Dr. Eugene H. Payne of the Department of Clinical Investigation, Parke, Davis & Company, Detroit. 3. Berliner, R. W., and others: Studies on the Chemotherapy of the Human Malarias: VI. The Physiological Disposition, Antimalarial Activity and Toxicity of Several Derivatives of 4-Aminoquinoline , J. Clin. Invest. 27:98 (May, Part (2) ) 1948.Crossref 4. Black, H.: The Treatment of Lupus Erythematosus with Mepacrine and Paraaminobenzoic Acid. Brit. J. Dermat. 65:195-203 ( (June) ) 1953.Crossref 5. Cole, H. N., Jr.; Chivington, P. V., Jr.; Cole, H. N., and Driver, J. R., Jr.: Treatment of Chronic Discoid Lupus Erythematosus with Quinacrine , J. A. M. A. 153:1515-1516 ( (Dec. 26) ) 1953.Crossref 6. Cramer, J. A., and Lewis, G. M.: Atabrine in the Treatment of Discoid Lupus Erythematosus , J. Invest. Dermat. 19:393-395 ( (Dec.) ) 1952.Crossref 7. Dubois, E. L.: Quinacrine (Atabrine) in Treatment of Systemic and Discoid Lupus Erythematosus , A. M. A. Arch. Int. Med. 94:131-141 ( (July) ) 1954.Crossref 8. Farber, E. M., and Driver, I. E.: Atabrine® and Chloroquine in the Treatment of Chronic Discoid Lupus Erythematosus: A Preliminary Report , Stanford M. Bull. 11:157-161 ( (Aug.) ) 1953. 9. Goldman, L.; Cole, D. P., and Preston, R. H.: Chloroquine Diphosphate in the Treatment of Discoid Lupus Erythematosus , J. A. M. A. 152:1428-1429 ( (Aug. 8) ) 1953.Crossref 10. Hathaway, J. C.: Therapeutic Committee Evaluation Report: The Value of Atabrine Therapy in Chronic Discoid Lupus Erythematosus , Tr. Pacific Dermat. A. (6th Annual Meeting) 1:40-41, 1954. 11. Herrmann, F., and Miller, O. B.: Pharmacologic and Pathogenic Effects of Mepacrine Hydrochloride (Atabrine®) on Human Skin. I. Clinical and Experimental Observations , Acta dermat.-venereol. 32:304-316 1952. 12. II. Microscopic Studies of Vital Staining Effects in Skin , Herrmann Acta dermat.-venereol. 32:317-332, 1952. 13. Novy, F. G., Jr.: Therapeutic Committee Evaluation Report: Chloroquine Therapy and Discoid Lupus Erythematosus , Tr. Pacific Dermat. A. (6th Annual Meeting) 1:37-39, 1954. 14. Ottolenghi-Lodigiani, F.: Treatment of Chronic Lupus Erythematodes: Local Intradermal Infiltration with Acridine Preparations , Hautarzt 6:24-27 ( (Jan.) ) 1955. 15. Page, F.: Treatment of Lupus Erythematosus with Mepacrine , Lancet , 2:755-758 ( (Oct. 27) ) 1951.Crossref 16. Parmer, L. G., and Sawitsky, A.: Fatal Aplastic Anemia Following Quinacrine Therapy in Chronic Discoid Lupus Erythematosus , J. A. M. A. 153:1172-1174 ( (Nov. 28) ) 1953.Crossref 17. Pillsbury, D. M., and Jacobson, C.: Treatment of Chronic Discoid Lupus Erythematosus with Chloroquine (Aralen) J. A. M. A. 154:1330-1333 ( (April 17) ) 1954.Crossref 18. Popoff, L., and Kutinscheff: Case Presentations , Dermat. Wchnschr. 116:186, 1943. 19. Prokoptchouk, A. J.: Treatment of Lupus Erythematosus with Acriquine , Vestnik venerol. i dermat. , No. (2) -3, pp. 23-26, 1940; 20. abstracted, Zentralbl. Haut. u. Geschlechtskr. 66:112, 1940-1941. 21. Rhodes, B. L., and Allende, M. F.: Treatment of Chronic Discoid Lupus Erythematosus with Quinacrine , California Med. 80:70-71 ( (Feb.) ) 1954. 22. Rogers, J., and Finn, O. A.: Synthetic Antimalarial Drugs in Chronic Discoid Lupus Erythematosus and Light Eruptions , A. M. A. Arch. Dermat. & Syph. 70:61-66 ( (July) ) 1954. 23. Sawicky, H. H.; Kanof, N. B.; Silverberg, M. G.; Braitman, M., and Kalish, K.: Therapeutic Assays of the Skin and Cancer Unit of the New York Hospital: Assay VII. Quinacrine Hydrochloride (Atabrine Hydrochloride) for Chronic Discoid Lupus Erythematosus , J. Invest. Dermat. 19:397-404 ( (Dec.) ) 1952. 24. Sommerville, J.; Devine, D. C., and Logan, J. C. P.: Lupus Erythematosus Treated with Mepacrine , Brit. J. Dermat. 64:417-419 ( (Nov.) ) 1952.Crossref 25. Sulzberger, M. B., and Baer, R. L.: Editorial comment, The 1952 Year Book of Dermatology and Syphilology , Chicago, The Year Book Publishers, Inc., 1953, p. 92. 26. Tye, M. J.; Schiff, B. L.; Collins, S. F.; Baler, G. R., and Appel, B.: Chronic Discoid Lupus Erythematosus: Treatment with Daraprim and Chloroquin Diphosphate (Aralen) , New England J. Med. 251:52-55 ( (July 8) ) 1954.Crossref 27. Wells, G. C.: Treatment of Chronic Discoid Lupus Erythematosus with Atabrine , J. Invest. Dermat. 19:405-407 ( (Dec.) ) 1952.Crossref 28. Zakon, S. J., and Gershenson, J.: Introduction of Quinacrine in Treatment of Lupus Erythematosus , A. M. A. Arch. Dermat. 71:520-521 ( (April) ) 1955.Crossref

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Jan 1, 1956

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