Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Antidepressant Response to Tricyclics and Urinary MHPG in Unipolar Patients: Clinical Response to Imipramine or Amitriptyline

Antidepressant Response to Tricyclics and Urinary MHPG in Unipolar Patients: Clinical Response to... Abstract The urinary excretion of the norepinephrine metabolite 3-methoxy4-hydroxyphenylglycol (MHPG) was measured in unipolar depressed patients before and during the fourth week of treatment with either imipramine hydrochloride or amitriptyline hydrochloride. On the basis of strict rating criteria, 24 patients were selected as either unequivocal responders or nonresponders. In the imipramine group the mean pretreatment MHPG was significantly lower in the nine responders than in the seven nonresponders; the converse was found with the amitriptyline patients. Of particular interest is that there was no overlap in individual values between the responders and nonresponders to either drug. Treatment with either imipramine or amitriptyline was associated with a significant decrease in MHPG excretion, which was independent of clinical response. References 1. Schildkraut JJ: The catecholamine hypothesis of affective disorders: A review of supporting evidence . Am J Psychiatry 122:509-522, 1965. 2. Bunney WE Jr, Davis JM: Norepinephrine in depressive reactions: A review . Arch Gen Psychiatry 13:483-494, 1965.Crossref 3. Goodwin FK, Bunney WE Jr: A psychobiological approach to affective illness . Psychiatr Ann 3:19-56, 1973. 4. Goodwin FK, Sack RL: Affective disorders: The catecholamine hypothesis revisited , in Usdin E, Snyder S (eds): Frontiers in Catecholamine Research . New York, Pergamon Press Inc, 1973, pp 1157-1164. 5. Schanberg SM, Schildkraut JJ, Breese GR: Metabolism of normetanephrine-H3 in rat brain—Identification of conjugated 3-methoxy-4-hydroxyphenylglycol as the major metabolite . Biochem Pharmacol 17:247-254, 1968.Crossref 6. Mannano E, Kirshner N, Nashold BS: The metabolism of C14noradrenaline by cat brain in vivo . J Neurochem 10:373-379, 1963.Crossref 7. Maas JW, Landis DH: In vivo studies of metabolism of norepinephrine in the central nervous system . J Pharmacol Exp Ther 163:147-162, 1968. 8. Post RM, Gordon EK, Goodwin FK, et al: Central norepinephrine metabolism in affective illness: MHPG in the cerebrospinal fluid . Science 179:1002-1003, 1973.Crossref 9. Maas JW, Dekirmenjian H, Garver D, et al: Excretion of catecholamine metabolites following intraventricular injection of 6-hydroxydopamine in the macaca speciosa . Eur J Pharmacol 23:121-130, 1973.Crossref 10. Maas JW, Fawcett JA, Dekirmenjian H: 3-Methoxy-4-hydroxy phenylglycol (MHPG) excretion in depressive states . Arch Gen Psychiatry 19:129-134, 1968.Crossref 11. Fawcett JA, Maas JW, Dekirmenjian H: Depression and MHPG excretion . Arch Gen Psychiatry 26:246-251, 1972.Crossref 12. Greenspan K, Schildkraut JJ, Gordon EK, et al: Catecholamine metabolism in affective disorders: III . J Psychiatr Res 7:171-183, 1970.Crossref 13. Bond PA, Jenner FA, Sampson GA: Daily variations of urine content of 3-methoxy-4-hydroxyphenylglycol in two manicdepressive patients . Psychol Med 2:81-85, 1972.Crossref 14. Jones FD, Maas JW, Dekirmenjian H, et al: Urinary catecholamine metabolites during behavioral changes in a patient with manic-depressive cycles . Science 179:300, 1973.Crossref 15. Maas JW, Fawcett JA, Dekirmenjian H: Catecholamine metabolism, depressive illness, and drug response . Arch Gen Psychiatry 26:252-262, 1972.Crossref 16. Schildkraut JJ: Norepinephrine metabolites as biochemical criteria for classifying depressive disorders and predicting responses to treatment: Preliminary findings . Am J Psychiatry 130:695-699, 1973. 17. Feighner JP, Robins E, Guze SB, et al: Diagnostic criteria for use in psychiatric research . Arch Gen Psychiatry 26:57-63, 1972.Crossref 18. Bunney WE Jr, Hamburg DA: Methods for reliable longitudinal observation of behavior . Arch Gen Psychiatry 9:280-294, 1963.Crossref 19. Dekirmenjian H, Maas JW: An improved procedure of 3-methoxy-4-hydroxyphenylethyleneglycol determination by gasliquid chromatography . Anal Biochem 35:113-122, 1970.Crossref 20. Klein DF, Davis JM: Diagnosis and Drug Treatment of Psychiatric Disorders . Baltimore, Williams & Wilkins Co, 1969. 21. Ebert M, Post RM, Goodwin FK: Effect of physical activity on urinary MHPG excretion in depressed patients . Lancet 2:766, 1972.Crossref 22. Rubin RT, Miller RG, Clark BR, et al: The stress of aircraft carrier landings: II. 3-methoxy-4-hydroxyphenylglycol excretion in naval aviators . Psychosom Med 32:589-597, 1970.Crossref 23. Maas JW, Dekirmenjian H, Fawcett JA: Catecholamine metabolism, depression and stress . Nature 230:330-331, 1971.Crossref 24. Maas JW, Dekirmenjian H, Jones F: The identification of depressed patients who have a disorder of NE metabolism and/or disposition , in Usdin E, Snyder S (eds): Frontiers in Catecholamine Research . New York, Pergamon Press Inc, 1973, pp 1091-1096. 25. Iversen LL: The Uptake and Storage of Noradrenaline in Sympathetic Nerves . Cambridge, Mass, Harvard University Press, 1967. 26. Mandell AJ, Segal DS, Kuczenski RT, et al: Some macromolecular mechanisms in CNS neurotransmitter pharmacology and their psychobiological organization , in McGaugh J (ed): The Chemistry of Mood, Motivation, and Memory . New York, Plenum Publishing Corp, 1972, pp 105-148. 27. Goodwin FK, Post RM, Sack RL: Cerebrospinal fluid MHPG in affective illness. Read before the annual meeting of the American Psychiatric Association, Detroit, Mich, 1974. 28. Schildkraut JJ, Dodge GA, Logue MA: Effects of tricyclic antidepressants on the uptake and metabolism of intracisternally administered norepinephrine H3 in rat brain . J Psychiatr Res 7:29-34, 1969.Crossref 29. Carlsson A, Corrodi H, Fuxe K, et al: Effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4,-alpha-dimethyl-meta-tyramine . Eur J Pharmacol 5:367-373, 1969.Crossref 30. Schubert J, Nyback H, Secvall G: Effect of antidepressant drugs on accumulation and disappearance of monoamines formed in vivo from labelled precursors in mouse brain . J Pharm Pharmacol 22:136-139, 1970.Crossref 31. Carlsson A, Corrodi H, Fuxe K, et al: Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4,-alpha-dimethyl-meta-tyramine . Eur J Pharmacol 5:367-373, 1969.Crossref 32. Tuck JR, Hamberger B, Sjoqvist F: Uptake of 3H-noradrenaline by adrenergic nerves of rat iris incubated in plasma from patients treated with various psychotropic drugs . Eur J Clin Pharmacol 4:212-216, 1972.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Antidepressant Response to Tricyclics and Urinary MHPG in Unipolar Patients: Clinical Response to Imipramine or Amitriptyline

Loading next page...
 
/lp/american-medical-association/antidepressant-response-to-tricyclics-and-urinary-mhpg-in-unipolar-R005HmYx0X
Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1975.01760190019001
Publisher site
See Article on Publisher Site

Abstract

Abstract The urinary excretion of the norepinephrine metabolite 3-methoxy4-hydroxyphenylglycol (MHPG) was measured in unipolar depressed patients before and during the fourth week of treatment with either imipramine hydrochloride or amitriptyline hydrochloride. On the basis of strict rating criteria, 24 patients were selected as either unequivocal responders or nonresponders. In the imipramine group the mean pretreatment MHPG was significantly lower in the nine responders than in the seven nonresponders; the converse was found with the amitriptyline patients. Of particular interest is that there was no overlap in individual values between the responders and nonresponders to either drug. Treatment with either imipramine or amitriptyline was associated with a significant decrease in MHPG excretion, which was independent of clinical response. References 1. Schildkraut JJ: The catecholamine hypothesis of affective disorders: A review of supporting evidence . Am J Psychiatry 122:509-522, 1965. 2. Bunney WE Jr, Davis JM: Norepinephrine in depressive reactions: A review . Arch Gen Psychiatry 13:483-494, 1965.Crossref 3. Goodwin FK, Bunney WE Jr: A psychobiological approach to affective illness . Psychiatr Ann 3:19-56, 1973. 4. Goodwin FK, Sack RL: Affective disorders: The catecholamine hypothesis revisited , in Usdin E, Snyder S (eds): Frontiers in Catecholamine Research . New York, Pergamon Press Inc, 1973, pp 1157-1164. 5. Schanberg SM, Schildkraut JJ, Breese GR: Metabolism of normetanephrine-H3 in rat brain—Identification of conjugated 3-methoxy-4-hydroxyphenylglycol as the major metabolite . Biochem Pharmacol 17:247-254, 1968.Crossref 6. Mannano E, Kirshner N, Nashold BS: The metabolism of C14noradrenaline by cat brain in vivo . J Neurochem 10:373-379, 1963.Crossref 7. Maas JW, Landis DH: In vivo studies of metabolism of norepinephrine in the central nervous system . J Pharmacol Exp Ther 163:147-162, 1968. 8. Post RM, Gordon EK, Goodwin FK, et al: Central norepinephrine metabolism in affective illness: MHPG in the cerebrospinal fluid . Science 179:1002-1003, 1973.Crossref 9. Maas JW, Dekirmenjian H, Garver D, et al: Excretion of catecholamine metabolites following intraventricular injection of 6-hydroxydopamine in the macaca speciosa . Eur J Pharmacol 23:121-130, 1973.Crossref 10. Maas JW, Fawcett JA, Dekirmenjian H: 3-Methoxy-4-hydroxy phenylglycol (MHPG) excretion in depressive states . Arch Gen Psychiatry 19:129-134, 1968.Crossref 11. Fawcett JA, Maas JW, Dekirmenjian H: Depression and MHPG excretion . Arch Gen Psychiatry 26:246-251, 1972.Crossref 12. Greenspan K, Schildkraut JJ, Gordon EK, et al: Catecholamine metabolism in affective disorders: III . J Psychiatr Res 7:171-183, 1970.Crossref 13. Bond PA, Jenner FA, Sampson GA: Daily variations of urine content of 3-methoxy-4-hydroxyphenylglycol in two manicdepressive patients . Psychol Med 2:81-85, 1972.Crossref 14. Jones FD, Maas JW, Dekirmenjian H, et al: Urinary catecholamine metabolites during behavioral changes in a patient with manic-depressive cycles . Science 179:300, 1973.Crossref 15. Maas JW, Fawcett JA, Dekirmenjian H: Catecholamine metabolism, depressive illness, and drug response . Arch Gen Psychiatry 26:252-262, 1972.Crossref 16. Schildkraut JJ: Norepinephrine metabolites as biochemical criteria for classifying depressive disorders and predicting responses to treatment: Preliminary findings . Am J Psychiatry 130:695-699, 1973. 17. Feighner JP, Robins E, Guze SB, et al: Diagnostic criteria for use in psychiatric research . Arch Gen Psychiatry 26:57-63, 1972.Crossref 18. Bunney WE Jr, Hamburg DA: Methods for reliable longitudinal observation of behavior . Arch Gen Psychiatry 9:280-294, 1963.Crossref 19. Dekirmenjian H, Maas JW: An improved procedure of 3-methoxy-4-hydroxyphenylethyleneglycol determination by gasliquid chromatography . Anal Biochem 35:113-122, 1970.Crossref 20. Klein DF, Davis JM: Diagnosis and Drug Treatment of Psychiatric Disorders . Baltimore, Williams & Wilkins Co, 1969. 21. Ebert M, Post RM, Goodwin FK: Effect of physical activity on urinary MHPG excretion in depressed patients . Lancet 2:766, 1972.Crossref 22. Rubin RT, Miller RG, Clark BR, et al: The stress of aircraft carrier landings: II. 3-methoxy-4-hydroxyphenylglycol excretion in naval aviators . Psychosom Med 32:589-597, 1970.Crossref 23. Maas JW, Dekirmenjian H, Fawcett JA: Catecholamine metabolism, depression and stress . Nature 230:330-331, 1971.Crossref 24. Maas JW, Dekirmenjian H, Jones F: The identification of depressed patients who have a disorder of NE metabolism and/or disposition , in Usdin E, Snyder S (eds): Frontiers in Catecholamine Research . New York, Pergamon Press Inc, 1973, pp 1091-1096. 25. Iversen LL: The Uptake and Storage of Noradrenaline in Sympathetic Nerves . Cambridge, Mass, Harvard University Press, 1967. 26. Mandell AJ, Segal DS, Kuczenski RT, et al: Some macromolecular mechanisms in CNS neurotransmitter pharmacology and their psychobiological organization , in McGaugh J (ed): The Chemistry of Mood, Motivation, and Memory . New York, Plenum Publishing Corp, 1972, pp 105-148. 27. Goodwin FK, Post RM, Sack RL: Cerebrospinal fluid MHPG in affective illness. Read before the annual meeting of the American Psychiatric Association, Detroit, Mich, 1974. 28. Schildkraut JJ, Dodge GA, Logue MA: Effects of tricyclic antidepressants on the uptake and metabolism of intracisternally administered norepinephrine H3 in rat brain . J Psychiatr Res 7:29-34, 1969.Crossref 29. Carlsson A, Corrodi H, Fuxe K, et al: Effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4,-alpha-dimethyl-meta-tyramine . Eur J Pharmacol 5:367-373, 1969.Crossref 30. Schubert J, Nyback H, Secvall G: Effect of antidepressant drugs on accumulation and disappearance of monoamines formed in vivo from labelled precursors in mouse brain . J Pharm Pharmacol 22:136-139, 1970.Crossref 31. Carlsson A, Corrodi H, Fuxe K, et al: Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4,-alpha-dimethyl-meta-tyramine . Eur J Pharmacol 5:367-373, 1969.Crossref 32. Tuck JR, Hamberger B, Sjoqvist F: Uptake of 3H-noradrenaline by adrenergic nerves of rat iris incubated in plasma from patients treated with various psychotropic drugs . Eur J Clin Pharmacol 4:212-216, 1972.Crossref

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Jan 1, 1975

References