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Antidepressant Monotherapy vs Sequential Pharmacotherapy and Mindfulness-Based Cognitive Therapy, or Placebo, for Relapse Prophylaxis in Recurrent Depression

Antidepressant Monotherapy vs Sequential Pharmacotherapy and Mindfulness-Based Cognitive Therapy,... ORIGINAL ARTICLE Antidepressant Monotherapy vs Sequential Pharmacotherapy and Mindfulness-Based Cognitive Therapy, or Placebo, for Relapse Prophylaxis in Recurrent Depression Zindel V. Segal, PhD; Peter Bieling, PhD; Trevor Young, MD; Glenda MacQueen, MD; Robert Cooke, MD; Lawrence Martin, MD; Richard Bloch, MA; Robert D. Levitan, MD Context: Mindfulness-based cognitive therapy (MBCT) depressant medication, or discontinued active medica- is a group-based psychosocial intervention designed to tion and were switched to placebo. enhance self-management of prodromal symptoms as- sociated with depressive relapse. Main Outcome Measure: Relapse was defined as a re- turn, for at least 2 weeks, of symptoms sufficient to meet Objective: To compare rates of relapse in depressed pa- the criteria for major depression on module A of the Struc- tients in remission receiving MBCT against mainte- tured Clinical Interview for DSM-IV. nance antidepressant pharmacotherapy, the current stan- dard of care. Results: Intention-to-treat analyses showed a signifi- cant interaction between the quality of acute-phase re- Design: Patients who met remission criteria after 8 mission and subsequent prevention of relapse in ran- months of algorithm-informed antidepressant treat- domized patients (P=.03). Among unstable remitters (1 ment were randomized to receive maintenance antide- or more Hamilton Rating Scale for Depression score 7 pressant http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Antidepressant Monotherapy vs Sequential Pharmacotherapy and Mindfulness-Based Cognitive Therapy, or Placebo, for Relapse Prophylaxis in Recurrent Depression

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Publisher
American Medical Association
Copyright
Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/archgenpsychiatry.2010.168
pmid
21135325
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Antidepressant Monotherapy vs Sequential Pharmacotherapy and Mindfulness-Based Cognitive Therapy, or Placebo, for Relapse Prophylaxis in Recurrent Depression Zindel V. Segal, PhD; Peter Bieling, PhD; Trevor Young, MD; Glenda MacQueen, MD; Robert Cooke, MD; Lawrence Martin, MD; Richard Bloch, MA; Robert D. Levitan, MD Context: Mindfulness-based cognitive therapy (MBCT) depressant medication, or discontinued active medica- is a group-based psychosocial intervention designed to tion and were switched to placebo. enhance self-management of prodromal symptoms as- sociated with depressive relapse. Main Outcome Measure: Relapse was defined as a re- turn, for at least 2 weeks, of symptoms sufficient to meet Objective: To compare rates of relapse in depressed pa- the criteria for major depression on module A of the Struc- tients in remission receiving MBCT against mainte- tured Clinical Interview for DSM-IV. nance antidepressant pharmacotherapy, the current stan- dard of care. Results: Intention-to-treat analyses showed a signifi- cant interaction between the quality of acute-phase re- Design: Patients who met remission criteria after 8 mission and subsequent prevention of relapse in ran- months of algorithm-informed antidepressant treat- domized patients (P=.03). Among unstable remitters (1 ment were randomized to receive maintenance antide- or more Hamilton Rating Scale for Depression score 7 pressant

Journal

JAMA PsychiatryAmerican Medical Association

Published: Dec 1, 2010

References