Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Anticoagulation in Kawasaki Disease

Anticoagulation in Kawasaki Disease Abstract Sir.—I read with great interest Dr Corrigan's editorial on platelet function in Kawasaki disease.1 Medical intervention in Kawasaki disease has previously been aimed at reducing the incidence of coronary artery aneurysm formation.2,3 However, once coronary aneurysms evolve, the appropriate use of anticoagulation therapy had not been seriously discussed prior to Dr Corrigan's article. In fact, most clinicians use antiplatelet therapy exclusively (eg, low-dose aspirin and/or dipyridamole). I would like to describe the management of an infant with Kawasaki disease whose initial course was complicated by coronary artery aneurysm and myocardial ischemia, as well as severe peripheral vasculitis. His large coronary aneurysm persisted, and he was successfully treated with warfarin sodium (Coumadin) anticoagulation and low-dose aspirin therapy for more than a year following the acute illness. However, shortly following withdrawal of warfarin and substitution with dipyridamole, he developed coronary thrombosis and myocardial infarction. Patient Report.—A 7-month-old male References 1. Corrigan JJ: Kawasaki disease and the plight of the platelet . AJDC 1986;140:1223-1224. 2. Kato H, Koike S, Yokoyama T: Kawasaki disease: Effect of treatment on coronary artery involvement . Pediatrics 1979;63:175-179. 3. Newburger JN, Takahashi M, Burns JC, et al: The treatment of Kawasaki syndrome with intravenous gamma globulin . N Engl J Med 1986;315:341-347.Crossref 4. TIMI Study Group: The thrombolysis in myocardial infarction (TIMI) trial . N Engl J Med 1985;312:932-936.Crossref 5. Burtt DM, Pollack P, Bianco JA: Intravenous streptokinase in an infant with Kawasaki's disease complicated by acute myocardial infarction . Pediatr Cardiol 1986;6:307-311. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Anticoagulation in Kawasaki Disease

Loading next page...
 
/lp/american-medical-association/anticoagulation-in-kawasaki-disease-xUHQBSfWyr
Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1987.04460070015003
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—I read with great interest Dr Corrigan's editorial on platelet function in Kawasaki disease.1 Medical intervention in Kawasaki disease has previously been aimed at reducing the incidence of coronary artery aneurysm formation.2,3 However, once coronary aneurysms evolve, the appropriate use of anticoagulation therapy had not been seriously discussed prior to Dr Corrigan's article. In fact, most clinicians use antiplatelet therapy exclusively (eg, low-dose aspirin and/or dipyridamole). I would like to describe the management of an infant with Kawasaki disease whose initial course was complicated by coronary artery aneurysm and myocardial ischemia, as well as severe peripheral vasculitis. His large coronary aneurysm persisted, and he was successfully treated with warfarin sodium (Coumadin) anticoagulation and low-dose aspirin therapy for more than a year following the acute illness. However, shortly following withdrawal of warfarin and substitution with dipyridamole, he developed coronary thrombosis and myocardial infarction. Patient Report.—A 7-month-old male References 1. Corrigan JJ: Kawasaki disease and the plight of the platelet . AJDC 1986;140:1223-1224. 2. Kato H, Koike S, Yokoyama T: Kawasaki disease: Effect of treatment on coronary artery involvement . Pediatrics 1979;63:175-179. 3. Newburger JN, Takahashi M, Burns JC, et al: The treatment of Kawasaki syndrome with intravenous gamma globulin . N Engl J Med 1986;315:341-347.Crossref 4. TIMI Study Group: The thrombolysis in myocardial infarction (TIMI) trial . N Engl J Med 1985;312:932-936.Crossref 5. Burtt DM, Pollack P, Bianco JA: Intravenous streptokinase in an infant with Kawasaki's disease complicated by acute myocardial infarction . Pediatr Cardiol 1986;6:307-311.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jul 1, 1987

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month