Abstract Sir.—I read with great interest Dr Corrigan's editorial on platelet function in Kawasaki disease.1 Medical intervention in Kawasaki disease has previously been aimed at reducing the incidence of coronary artery aneurysm formation.2,3 However, once coronary aneurysms evolve, the appropriate use of anticoagulation therapy had not been seriously discussed prior to Dr Corrigan's article. In fact, most clinicians use antiplatelet therapy exclusively (eg, low-dose aspirin and/or dipyridamole). I would like to describe the management of an infant with Kawasaki disease whose initial course was complicated by coronary artery aneurysm and myocardial ischemia, as well as severe peripheral vasculitis. His large coronary aneurysm persisted, and he was successfully treated with warfarin sodium (Coumadin) anticoagulation and low-dose aspirin therapy for more than a year following the acute illness. However, shortly following withdrawal of warfarin and substitution with dipyridamole, he developed coronary thrombosis and myocardial infarction. Patient Report.—A 7-month-old male References 1. Corrigan JJ: Kawasaki disease and the plight of the platelet . AJDC 1986;140:1223-1224. 2. Kato H, Koike S, Yokoyama T: Kawasaki disease: Effect of treatment on coronary artery involvement . Pediatrics 1979;63:175-179. 3. Newburger JN, Takahashi M, Burns JC, et al: The treatment of Kawasaki syndrome with intravenous gamma globulin . N Engl J Med 1986;315:341-347.Crossref 4. TIMI Study Group: The thrombolysis in myocardial infarction (TIMI) trial . N Engl J Med 1985;312:932-936.Crossref 5. Burtt DM, Pollack P, Bianco JA: Intravenous streptokinase in an infant with Kawasaki's disease complicated by acute myocardial infarction . Pediatr Cardiol 1986;6:307-311.
American Journal of Diseases of Children – American Medical Association
Published: Jul 1, 1987
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera