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Antichlamydial Antimicrobial Therapy for Asthma

Antichlamydial Antimicrobial Therapy for Asthma Abstract I would like to comment on the interesting report by Emre et al1 associating Chlamydia pneumoniae infection and reactive airway disease in children. They found evidence for C pneumoniae infection in 25 (21.2%) of 118 children with acute episodes of wheezing; nine had positive cultures for C pneumoniae but did not have diagnostic antibody, 13 had diagnostic antibody but had negative cultures, and three had positive cultures and positive serologic results. They also report that eradication of the organism after the treatment of wheezing in children with positive cultures was associated with symptomatic and laboratory improvement. They hypothesize that chronic C pneumoniae infection can produce chronic airway inflammation and bronchial hyperresponsiveness. Their data also support their statement that use of serologic testing alone would have underestimated the prevalence of C pneumoniae infection in children. An unanswered question raised by their data is: Did some children with negative cultures and References 1. Emre U, Roblin PM, Gelling M, et al. The association of Chlamydia pneumoniae infection and reactive airway disease in children . Arch Pediatr Adolesc Med . 1994;148:727-732.Crossref 2. Hahn DL. Clinical experience with anti-chlamydial therapy for adult-onset asthma . Am Rev Respir Dis . 1993;147( (pt 2) ):A297. Abstract.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Pediatrics & Adolescent Medicine American Medical Association

Antichlamydial Antimicrobial Therapy for Asthma

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Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
1072-4710
eISSN
1538-3628
DOI
10.1001/archpedi.1995.02170140101023
Publisher site
See Article on Publisher Site

Abstract

Abstract I would like to comment on the interesting report by Emre et al1 associating Chlamydia pneumoniae infection and reactive airway disease in children. They found evidence for C pneumoniae infection in 25 (21.2%) of 118 children with acute episodes of wheezing; nine had positive cultures for C pneumoniae but did not have diagnostic antibody, 13 had diagnostic antibody but had negative cultures, and three had positive cultures and positive serologic results. They also report that eradication of the organism after the treatment of wheezing in children with positive cultures was associated with symptomatic and laboratory improvement. They hypothesize that chronic C pneumoniae infection can produce chronic airway inflammation and bronchial hyperresponsiveness. Their data also support their statement that use of serologic testing alone would have underestimated the prevalence of C pneumoniae infection in children. An unanswered question raised by their data is: Did some children with negative cultures and References 1. Emre U, Roblin PM, Gelling M, et al. The association of Chlamydia pneumoniae infection and reactive airway disease in children . Arch Pediatr Adolesc Med . 1994;148:727-732.Crossref 2. Hahn DL. Clinical experience with anti-chlamydial therapy for adult-onset asthma . Am Rev Respir Dis . 1993;147( (pt 2) ):A297. Abstract.Crossref

Journal

Archives of Pediatrics & Adolescent MedicineAmerican Medical Association

Published: Feb 1, 1995

References