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Antibody Response Following Customary Use of MMR Vaccine-Reply

Antibody Response Following Customary Use of MMR Vaccine-Reply In Reply.— The "bottom line" in the evaluation of a vaccine is how it influences the disease it is intended to prevent; antibody determinations merely provide a rough guide as to what one might expect in this regard. The bottom line for rubella as well as measles and mumps vaccines looks very good. Indeed, we now talk of the "elimination" of measles and rubella. Serological assays for measuring response to immunization can be made more sensitive and, consequentlyly, increase the apparent effectiveness of the vaccine or vice versa. In our article, we tried to provide an "epidemiologic standardization" of the assays by adjusting their specificity and sensitivity using populations of known immune or susceptible persons. To suggest, however, that this could be used in lieu of the performance of the vaccine in preventing disease would be naive. The difference between our serological results and those of Dr Balfour was not http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Antibody Response Following Customary Use of MMR Vaccine-Reply

JAMA , Volume 251 (24) – Jun 22, 1984

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1984.03340480017013
Publisher site
See Article on Publisher Site

Abstract

In Reply.— The "bottom line" in the evaluation of a vaccine is how it influences the disease it is intended to prevent; antibody determinations merely provide a rough guide as to what one might expect in this regard. The bottom line for rubella as well as measles and mumps vaccines looks very good. Indeed, we now talk of the "elimination" of measles and rubella. Serological assays for measuring response to immunization can be made more sensitive and, consequentlyly, increase the apparent effectiveness of the vaccine or vice versa. In our article, we tried to provide an "epidemiologic standardization" of the assays by adjusting their specificity and sensitivity using populations of known immune or susceptible persons. To suggest, however, that this could be used in lieu of the performance of the vaccine in preventing disease would be naive. The difference between our serological results and those of Dr Balfour was not

Journal

JAMAAmerican Medical Association

Published: Jun 22, 1984

There are no references for this article.